Adiponectin Stimulates AMP-Activated Protein Kinase in the Hypothalamus and Increases Food Intake

Kubota, Naoto; Yano, Wataru; Kubota, Tetsuya; Yamauchi, Toshimasa; Itoh, Shinsuke; Kumagai, Hiroki; Kozono, Hideki; Takamoto, Iseki; Okamoto, Shiki; Shiuchi, Tetsuya; Suzuki, Ryo; Satoh, Hidemi; Tsuchida, Atsushi; Moroi, Masao; Sugi, Kaoru; Noda, Tetsuo; Ebinuma, Hiroyuki; Ueta, Yoichi; Kondo, Tatsuya; Araki, Eiichi; Ezaki, Osamu; Nagai, Ryozo; Tobe, Kazuyuki; Terauchi, Yasuo; Ueki, Kohjiro; Minokoshi, Yasuhiko; Kadowaki, Takashi

doi:10.1016/j.cmet.2007.06.003

Cited by 844Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Adiponectin Stimulates AMP-Activated Protein Kinase in the Hypothalamus and Increases Food Intake

Open access

Kubota, Naoto, Yano, Wataru, Kubota, Tetsuya, Yamauchi, Toshimasa, Itoh, Shinsuke, Kumagai, Hiroki, Kozono, Hideki, Takamoto, Iseki +19 more·2007·Cell Metabolism

DOI 10.1016/j.cmet.2007.06.003

Open this paper in CoChat — free account Open PDF

Abstract

Adiponectin has been shown to stimulate fatty acid oxidation and enhance insulin sensitivity through the activation of AMP-activated protein kinase (AMPK) in the peripheral tissues. The effects of adiponectin in the central nervous system, however, are still poorly understood. Here, we show that adiponectin enhances AMPK activity in the arcuate hypothalamus (ARH) via its receptor AdipoR1 to stimulate food intake; this stimulation of food intake by adiponectin was attenuated by dominant-negative AMPK expression in the ARH. Moreover, adiponectin also decreased energy expenditure. Adiponectin-deficient mice showed decreased AMPK phosphorylation in the ARH, decreased food intake, and increased energy expenditure, exhibiting resistance to high-fat-diet-induced obesity. Serum and cerebrospinal fluid levels of adiponectin and expression of AdipoR1 in the ARH were increased during fasting and decreased after refeeding. We conclude that adiponectin stimulates food intake and decreases energy expenditure during fasting through its effects in the central nervous system.

Integrity signals

Registry

Crossref · 10.1016/j.cmet.2007.06.003

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

In the brain, adiponectin activates AMPK signaling in hypothalamic ARC, resulting in an increase in food intake and a reduction in energy expenditure, suggesting that in the hypothalamus adiponectin promotes feeding and inhibits the anorexigenic effects of leptin.
“In the brain, adiponectin activates AMPK signaling in hypothalamic ARC, resulting in an increase in food intake and a reduction in energy expenditure, suggesting that in the hypothalamus adiponectin promotes feeding and inhibits the anorexigenic effects of leptin 55, 56.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [56]
Adiponectin levels increase in low glucose and low insulin conditions, at least in the cerebrospinal fluid.
“In contrast to leptin, adiponectin levels increase in low glucose and low insulin conditions, at least in the cerebrospinal fluid (CSF) 55, 56.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [56]
In pathological conditions of obesity, the reduction in CSF levels of adiponectin that is accompanied by feeding is lost, thus maintaining a high food intake behavior even in high energy conditions.
“In pathological conditions of obesity, the reduction in CSF levels of adiponectin that is accompanied by feeding is lost, thus maintaining a “high food intake behavior” even in conditions that are not of energy scarcity (high energy conditions) 56.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [56]

The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859 · see citing works
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915 · see citing works
Self-citation
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., Kita, S., Ueki, K., et al. (2002) · Nature Medicine · doi:10.1038/nm788 · Cited by 4,238 · see citing works
Self-citation
A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes
Scherer, P. E., Williams, S. P., Fogliano, M., Baldini, G., & Lodish, H. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.26746 · Cited by 3,238 · see citing works
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
Yamauchi, T., Kamon, J., Ito, Y., Tsuchida, A., Yokomizo, T., Kita, S., Sugiyama, T., Miyagishi, M., Hara, K., Tsunoda, M., et al. (2003) · Nature · doi:10.1038/nature01705 · Cited by 3,176 · see citing works
mouse brain in stereotaxic coordinates
Franklin, K. B. J., & Paxinos, G. (1997) · Cited by 3,083 · see citing works
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
Kadowaki, T. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29126 · Cited by 2,824 · see citing works
Self-citation
The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
Berg, A. H., Combs, T. P., Du, X., Brownlee, M., & Scherer, P. E. (2001) · Nature Medicine · doi:10.1038/90992 · Cited by 2,526 · see citing works
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
Minokoshi, Y., Kim, Y.-B., Peroni, O. D., Fryer, L. G. D., Müller, C., Carling, D., & Kahn, B. B. (2002) · Nature · doi:10.1038/415339a · Cited by 2,053 · see citing works
Self-citation
Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice
Fruebis, J., Tsao, T., Javorschi, S., Ebbets-Reed, D., Erickson, M., Yen, F. T., Bihain, B. E., & Lodish, H. F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.2005 · Cited by 1,987 · see citing works
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
Minokoshi, Y., Alquier, T., Furukawa, N., Kim, Y.-B., Lee, A., Xue, B., Mu, J., Foufelle, F., Ferré, P., Birnbaum, M. J., et al. (2004) · Nature · doi:10.1038/nature02440 · Cited by 1,637 · see citing works
Self-citation
Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions
Yamauchi, T., Nio, Y., Maki, T., Kobayashi, M., Takazawa, T., Iwabu, M., Okada-Iwabu, M., Kawamoto, S., Kubota, N., Kubota, T., et al. (2007) · Nature Medicine · doi:10.1038/nm1557 · Cited by 1,396 · see citing works
Self-citation
PPARγ Mediates High-Fat Diet–Induced Adipocyte Hypertrophy and Insulin Resistance
Kubota, N., Terauchi, Y., Miki, H., Tamemoto, H., Yamauchi, T., Komeda, K., Satoh, S., Nakano, R., Ishii, C., 杉山, 拓., et al. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80210-5 · Cited by 1,342 · see citing works
Self-citation
Obesity-associated improvements in metabolic profile through expansion of adipose tissue
Kim, J.-Y., van de Wall, E., Laplante, M., Azzara, A., Trujillo, M. E., Hofmann, S. M., Schraw, T., Durand, J. L., Li, H., Li, G., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31021 · Cited by 1,310 · see citing works
Disruption of Adiponectin Causes Insulin Resistance and Neointimal Formation
Kubota, N., Terauchi, Y., Yamauchi, T., Kubota, T., Moroi, M., Matsui, J., Eto, K., Yamashita, T., Kamon, J., Satoh, H., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200251200 · Cited by 1,213 · see citing works
Self-citation
The AMP-activated protein kinase pathway – new players upstream and downstream
Hardie, D. G. (2004) · Journal of Cell Science · doi:10.1242/jcs.01540 · Cited by 1,136 · see citing works
Disruption of adiponectin causes insulin resistance and neointimal formation
Froguel, P. (2002) · HAL · Cited by 1,126 · see citing works
Structure-Function Studies of the Adipocyte-secreted Hormone Acrp30/Adiponectin
Pajvani, U. B., Du, X., Combs, T. P., Berg, A. H., Rajala, M. W., Schulthess, T., Engel, J., Brownlee, M., & Scherer, P. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207198200 · Cited by 1,090 · see citing works
Adipose Tissue
Scherer, P. E. (2006) · Diabetes · doi:10.2337/db06-0263 · Cited by 1,067 · see citing works
Diabetes, Obesity, and the Brain
Schwartz, M. W., & Porte, D. (2005) · Science · doi:10.1126/science.1104344 · Cited by 841 · see citing works
Adiponectin acts in the brain to decrease body weight
Qi, Y., Takahashi, N., Hileman, S. M., Patel, H. R., Berg, A. H., Pajvani, U. B., Scherer, P. E., & Ahima, R. S. (2004) · Nature Medicine · doi:10.1038/nm1029 · Cited by 809 · see citing works
AMP-activated Protein Kinase Plays a Role in the Control of Food Intake
Andersson-Hall, U. K., Filipsson, K., Abbott, C. R., Woods, A., Smith, K. L., Bloom, S. R., Carling, D., & Small, C. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c300557200 · Cited by 756 · see citing works
Mice Lacking Adiponectin Show Decreased Hepatic Insulin Sensitivity and Reduced Responsiveness to Peroxisome Proliferator-activated Receptor γ Agonists
Nawrocki, A. R., Rajala, M. W., Tomás, E., Pajvani, U. B., Saha, A. K., Trumbauer, M. E., Pang, Z., Chen, A. S., Ruderman, N. B., Chen, H., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505311200 · Cited by 640 · see citing works
AMPK, the metabolic syndrome and cancer
Luo, Z., Saha, A. K., Xiang, X., & Ruderman, N. B. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.12.011 · Cited by 426 · see citing works
AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues
Xue, B., & Kahn, B. B. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.113217 · Cited by 338 · see citing works
Pioglitazone Ameliorates Insulin Resistance and Diabetes by Both Adiponectin-dependent and -independent Pathways
Kubota, N., Terauchi, Y., Kubota, T., Kumagai, H., Itoh, S., Satoh, H., Yano, W., Ogata, H., Tokuyama, K., Takamoto, I., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m505649200 · Cited by 327 · see citing works
Self-citation
Adiponectin and Resistin in Human Cerebrospinal Fluid and Expression of Adiponectin Receptors in the Human Hypothalamus
Kos, K., Harte, A. L., da Silva, N. F., Tonchev, A. B., Chaldakov, G., James, S. G., Snead, D. R. J., Hoggart, B., O’Hare, J. P., McTernan, P. G., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1841 · Cited by 234 · see citing works
Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization
Kondo, T., Vicent, D., Suzuma, K., Yanagisawa, M., King, G. L., Holzenberger, M., & Kahn, C. R. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17455 · Cited by 228 · see citing works
Self-citation
Adiponectin complexes in human cerebrospinal fluid: distinct complex distribution from serum
Kusminski, C. M., McTernan, P. G., Schraw, T., Kos, K., O’Hare, J. P., Ahima, R. S., Kumar, S., & Scherer, P. E. (2007) · Diabetologia · doi:10.1007/s00125-006-0577-9 · Cited by 223 · see citing works
Adiponectin Does Not Cross the Blood-Brain Barrier but Modifies Cytokine Expression of Brain Endothelial Cells
Spranger, J., Verma, S., Göhring, I., Bobbert, T., Seifert, J., Sindler, A. L., Pfeiffer, A. F. H., Hileman, S. M., Tschöp, M. H., & Banks, W. A. (2006) · Diabetes · doi:10.2337/diabetes.55.01.06.db05-1077 · Cited by 217 · see citing works
AMP-activated protein kinase: balancing the scales
Carling, D. (2004) · Biochimie · doi:10.1016/j.biochi.2004.10.017 · Cited by 201 · see citing works
Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization
Kondo, T., Vicent, D., Suzuma, K., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317455 · Cited by 190 · see citing works
Self-citation
Differential Regulation of Leptin Transport by the Choroid Plexus and Blood-Brain Barrier and High Affinity Transport Systems for Entry into Hypothalamus and Across the Blood-Cerebrospinal Fluid Barrier
Zloković, B. V., Jovanovic, S. S., Miao, W., Samara, S., Verma, S. P., & Farrell, C. L. (2000) · Endocrinology · doi:10.1210/endo.141.4.7435 · Cited by 170 · see citing works
Selective purification and characterization of adiponectin multimer species from human plasma
Hada, Y., Yamauchi, T., Waki, H., Tsuchida, A., Hara, K., Yago, H., Miyazaki, O., Ebinuma, H., & Kadowaki, T. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.03.004 · Cited by 151 · see citing works
Self-citation
Multiple Regulatory Roles of a Novel Saccharomyces cerevisiae Protein, Encoded by YOL002c, in Lipid and Phosphate Metabolism
Karpichev, I. V., Cornivelli, L., & Small, G. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202045200 · Cited by 87 · see citing works
Role of hypothalamic 5′-AMP-activated protein kinase in the regulation of food intake and energy homeostasis
Kim, M., & Lee, K. (2005) · Journal of Molecular Medicine · doi:10.1007/s00109-005-0659-z · Cited by 71 · see citing works
S–100 Antigen‐Positive Folliculostellate Cells are not the Source of IL‐6 Gene Expression in Human Pituitary Adenomas
Ueta, Y., Levy, A., Chowdrey, H. S., & Lightman, S. L. (1995) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1995.tb00783.x · Cited by 31 · see citing works
Self-citation
Triglycerides and toggling the tummy
Kahn, C. R. (2000) · Nature Genetics · doi:10.1038/75610 · Cited by 31 · see citing works

Flagged first, then by citations

Sorted by citations

AMPK: a nutrient and energy sensor that maintains energy homeostasis
Hardie, D. G., Ross, F. A., & Hawley, S. A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3311 · Cited by 4,602 · see citing works
What we talk about when we talk about fat
Rosen, E. D., & Spiegelman, B. M. (2014) · Cell · doi:10.1016/j.cell.2013.12.012 · Cited by 2,373 · see citing works
AMPK in Health and Disease
Steinberg, G. R., & Kemp, B. E. (2009) · Physiological Reviews · doi:10.1152/physrev.00011.2008 · Cited by 1,633 · see citing works
Adipose tissue as an endocrine organ
Galić, S., Oakhill, J. S., & Steinberg, G. R. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.08.018 · Cited by 1,597 · see citing works
AMPK and PPARδ Agonists Are Exercise Mimetics
Narkar, V. A., Downes, M., Yu, R. T., Embler, E., Wang, Y.-X., Banayo, E., Mihaylova, M. M., Nelson, M. C., Zou, Y., Juguilon, H., et al. (2008) · Cell · doi:10.1016/j.cell.2008.06.051 · Cited by 1,222 · see citing works
State of the art paper Biochemistry of adipose tissue: an endocrine organ
Coelho, M., Oliveira, T., & Fernandes, R. (2013) · Archives of Medical Science · doi:10.5114/aoms.2013.33181 · Cited by 1,125 · see citing works
AMPK: An Emerging Drug Target for Diabetes and the Metabolic Syndrome
Zhang, B. B., Zhou, G., & Li, C. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.03.012 · Cited by 1,028 · see citing works
Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome
Maury, E., & Brichard, S. M. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.07.031 · Cited by 1,026 · see citing works
Adipokines and Insulin Resistance
Rabe, K., Lehrke, M., Parhofer, K. G., & Broedl, U. C. (2008) · Molecular Medicine · doi:10.2119/2008-00058.rabe · Cited by 814 · see citing works
Adipocytokines and the Metabolic Complications of Obesity
Rasouli, N., & Kern, P. A. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1613 · Cited by 744 · see citing works
Adipose tissue in control of metabolism
Luo, L., & Liu, M. (2016) · Journal of Endocrinology · doi:10.1530/joe-16-0211 · Cited by 707 · see citing works
The Role of Adiponectin in Cancer: A Review of Current Evidence
Dalamaga, Μ., Diakopoulos, K. N., & Mantzoros, C. S. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1015 · Cited by 639 · see citing works
Adiponectin regulation and function
Fang, H., & Judd, R. L. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170046 · Cited by 631 · see citing works
Fasting and cancer: molecular mechanisms and clinical application
Nencioni, A., Caffa, I., Cortellino, S., & Longo, V. D. (2018) · Nature Reviews Cancer · doi:10.1038/s41568-018-0061-0 · Cited by 518 · see citing works
AMPK: a metabolic gauge regulating whole-body energy homeostasis
Lage, R., Diéguez, C., Vidal‐Puig, A., & López, M. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2008.09.007 · Cited by 503 · see citing works
AMPK: positive and negative regulation, and its role in whole-body energy homeostasis
Hardie, D. G. (2015) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.09.004 · Cited by 485 · see citing works
Insulin resistance in chronic kidney disease: a systematic review
Spoto, B., Pisano, A., & Zoccali, C. (2016) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00340.2016 · Cited by 453 · see citing works
AMPK activation: a therapeutic target for type 2 diabetes?
Saha, A. K., Coughlan, K. A., Valentine, R. J., & Ruderman, N. B. (2014) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s43731 · Cited by 440 · see citing works
Adiponectin in insulin resistance: lessons from translational research
Ziemke, F., & Mantzoros, C. S. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28449c · Cited by 422 · see citing works
Post-translational modifications of adiponectin: mechanisms and functional implications
Wang, Y., Lam, K. S. L., Yau, M.-H., & Xu, A. (2008) · Biochemical Journal · doi:10.1042/bj20071492 · Cited by 405 · see citing works
Adiponectin and inflammation: Consensus and controversy
Fantuzzi, G. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.10.018 · Cited by 402 · see citing works
Adiponectin signaling and function in insulin target tissues
Ruan, H., & Dong, L. Q. (2016) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjw014 · Cited by 395 · see citing works
Brain Regulation of Appetite and Satiety
Ahima, R. S., & Antwi, D. A. (2008) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2008.08.005 · Cited by 387 · see citing works
Adiponectin receptors: A review of their structure, function and how they work
Yamauchi, T., Iwabu, M., Okada‐Iwabu, M., & Kadowaki, T. (2013) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2013.09.003 · Cited by 355 · see citing works
Self-citation
Physiological and pathophysiological roles of adiponectin and adiponectin receptors in the integrated regulation of metabolic and cardiovascular diseases
Yamauchi, T., & Kadowaki, T. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.233 · Cited by 339 · see citing works
Self-citation
Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin
Yau, S. Y., Li, A., Hoo, R. L. C., Ching, Y. P., Christie, B. R., Lee, T. M. C., Xu, A., & So, K.-F. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1415219111 · Cited by 326 · see citing works
Adiponectin action from head to toe
Brochu‐Gaudreau, K., Rehfeldt, C., Blouin, R., Bordignon, V., Murphy, B. D., & Palin, M. (2009) · Endocrine · doi:10.1007/s12020-009-9278-8 · Cited by 323 · see citing works
The secretory function of adipocytes in the physiology of white adipose tissue
Wang, P., Mariman, E., Renes, J., & Keijer, J. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21386 · Cited by 318 · see citing works
Adipogenesis
Sarjeant, K., & Stephens, J. M. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008417 · Cited by 328 · see citing works
Adipokines and the Peripheral and Neural Control of Energy Balance
Ahima, R. S., & Lazar, M. A. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0529 · Cited by 314 · see citing works
AMPK: Lessons from transgenic and knockout animals
Viollet, B. (2009) · Frontiers in bioscience · doi:10.2741/3229 · Cited by 314 · see citing works
Hypothalamic AMPK: a canonical regulator of whole-body energy balance
López, M., Nogueiras, R., Tena‐Sempere, M., & Diéguez, C. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.67 · Cited by 312 · see citing works
AMPK in the brain: its roles in energy balance and neuroprotection
Ronnett, G. V., Ramamurthy, S., Kleman, A. M., Landree, L. E., & Aja, S. M. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05916.x · Cited by 300 · see citing works
AMPK as a mediator of hormonal signalling
Lim, C. T., Kola, B., & Korbonits, M. (2009) · Journal of Molecular Endocrinology · doi:10.1677/jme-09-0063 · Cited by 298 · see citing works
The Role of Leptin and Adiponectin in Obesity-Associated Cognitive Decline and Alzheimer’s Disease
Forny‐Germano, L., Felice, F. G. D., & Vieira, M. N. N. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.01027 · Cited by 298 · see citing works
Review on leptin and adiponectin responses and adaptations to acute and chronic exercise
Bouassida, A., Chamari, K., Zaouali, M., Feki, Y., Zbidi, A., & Tabka, Z. (2010) · British Journal of Sports Medicine · doi:10.1136/bjsm.2008.046151 · Cited by 290 · see citing works
APPL1: role in adiponectin signaling and beyond
Deepa, S. S., & Dong, L. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90731.2008 · Cited by 287 · see citing works
Adipokines: a link between obesity and dementia?
Kiliaan, A. J., Arnoldussen, I. A. C., & Gustafson, D. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70085-7 · Cited by 285 · see citing works
AMPK: Regulating Energy Balance at the Cellular and Whole Body Levels
Hardie, D. G., & Ashford, M. L. J. (2014) · Physiology · doi:10.1152/physiol.00050.2013 · Cited by 280 · see citing works
Adiponectin receptor signalling in the brain
Thundyil, J., Pavlovski, D., Sobey, C. G., & Arumugam, T. V. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01560.x · Cited by 282 · see citing works
Arcuate Nucleus-Dependent Regulation of Metabolism—Pathways to Obesity and Diabetes Mellitus
Jaïs, A., & Brüning, J. C. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab025 · Cited by 282 · see citing works
Mechanistic Links Between Obesity, Diabetes, and Blood Pressure: Role of Perivascular Adipose Tissue
Saxton, S. N., Clark, B., Withers, S., Eringa, E. C., & Heagerty, A. M. (2019) · Physiological Reviews · doi:10.1152/physrev.00034.2018 · Cited by 277 · see citing works
Leptin and adiponectin: from energy and metabolic dysbalance to inflammation and autoimmunity.
Štofková, A. (2009) · PubMed · Cited by 273 · see citing works
The adipocyte as an endocrine organ in the regulation of metabolic homeostasis
Harwood, H. J. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.12.010 · Cited by 273 · see citing works
The physiological and pathophysiological role of adiponectin and adiponectin receptors in the peripheral tissues and CNS
Kadowaki, T., Yamauchi, T., & Kubota, N. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.11.070 · Cited by 270 · see citing works
Self-citation
AMP-activated protein kinase: maintaining energy homeostasis at the cellular and whole-body levels
Hardie, D. G. (2014) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071812-161148 · Cited by 281 · see citing works
Adipokines: New potential therapeutic target for obesity and metabolic, rheumatic, and cardiovascular diseases
Recinella, L., Orlando, G., Ferrante, C., Chiavaroli, A., Brunetti, L., & Leone, S. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.578966 · Cited by 261 · see citing works
Metabolic Slowing with Massive Weight Loss despite Preservation of Fat-Free Mass
Johannsen, D. L., Knuth, N. D., Huizenga, R., Rood, J. C., Ravussin, E., & Hall, K. D. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1444 · Cited by 254 · see citing works
C1q/TNF-related Protein-3 (CTRP3), a Novel Adipokine That Regulates Hepatic Glucose Output
Peterson, J. M., Wei, Z., & Wong, G. W. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.180695 · Cited by 258 · see citing works
Extracellular vesicles mediate the communication of adipose tissue with brain and promote cognitive impairment associated with insulin resistance
Wang, J., Li, L., Zhang, Z., Zhang, X., Zhu, Y., Zhang, C., & Bi, Y. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.08.004 · Cited by 251 · see citing works
Metabolic function of the CTRP family of hormones
Seldin, M. M., Tan, S. Y., & Wong, G. W. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9255-7 · Cited by 244 · see citing works
Adiponectin, Cardiovascular Function, and Hypertension
Wang, Z. V., & Scherer, P. E. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.099424 · Cited by 247 · see citing works
Adiponectin: a versatile player of innate immunity
Luo, Y., & Liu, M. (2016) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjw012 · Cited by 244 · see citing works
Physiological, Pharmacological, and Nutritional Regulation of Circulating Adiponectin Concentrations in Humans
Swarbrick, M. M., & Havel, P. J. (2008) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2007.0029 · Cited by 237 · see citing works
Insulin Resistance in Obesity as the Underlying Cause for the Metabolic Syndrome
Gallagher, E. J., LeRoith, D., & Karnieli, E. (2010) · Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20212 · Cited by 238 · see citing works
Transcriptional and post-translational regulation of adiponectin
Liu, M., & Liu, F. (2009) · Biochemical Journal · doi:10.1042/bj20091045 · Cited by 235 · see citing works
Obesity and dementia: Adipokines interact with the brain
Arnoldussen, I. A. C., Kiliaan, A. J., & Gustafson, D. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.03.002 · Cited by 219 · see citing works
The Deep Correlation between Energy Metabolism and Reproduction: A View on the Effects of Nutrition for Women Fertility
Fontana, R., & Torre, S. D. (2016) · Nutrients · doi:10.3390/nu8020087 · Cited by 218 · see citing works
Adiponectin Represses Colon Cancer Cell Proliferation via AdipoR1- and -R2-Mediated AMPK Activation
Kim, A. Y., Lee, Y. S., Kim, K. H., Lee, J. H., Lee, H. K., Jang, S. H., Kim, S., Lee, G. Y., Lee, J.-W., Jung, S.-A., et al. (2010) · Molecular Endocrinology · doi:10.1210/me.2009-0498 · Cited by 214 · see citing works
A Review of Bioactive Factors in Human Breastmilk: A Focus on Prematurity
Gila-Díaz, A., Arribas, S. M., Algara, A., Martin-Cabrejas, M. A., de Pablo, Á. L. L., de Pipaón, M. S., & Ramiro‐Cortijo, D. (2019) · Nutrients · doi:10.3390/nu11061307 · Cited by 212 · see citing works
The brown fat secretome: metabolic functions beyond thermogenesis
Wang, G.-X., Zhao, X.-Y., & Lin, J. D. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.03.002 · Cited by 206 · see citing works
The role of NPY in hypothalamic mediated food intake
Mercer, R. E., Chee, M. J. S., & Colmers, W. F. (2011) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.06.001 · Cited by 194 · see citing works
Adiponectin is critical in determining susceptibility to depressive behaviors and has antidepressant-like activity
Liu, J., Guo, M., Zhang, D., Cheng, S.-Y., Liu, M., Ding, J., Scherer, P. E., Liu, F., & Lu, X. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202835109 · Cited by 191 · see citing works
Forkhead Transcription Factor FoxO1 in Adipose Tissue Regulates Energy Storage and Expenditure
Nakae, J., Cao, Y., Oki, M., Orba, Y., Sawa, H., Kiyonari, H., Iskandar, K., Suga, K., Lombès, M., & Hayashi, Y. (2007) · Diabetes · doi:10.2337/db07-0698 · Cited by 187 · see citing works
Adiponectin suppresses hepatic SREBP1c expression in an AdipoR1/LKB1/AMPK dependent pathway
Awazawa, M., Ueki, K., Inabe, K., Yamauchi, T., Kaneko, K., Okazaki, Y., Bardeesy, N. M., Ohnishi, S., Nagai, R., & Kadowaki, T. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.02.131 · Cited by 186 · see citing works
Self-citation
What is the role of adiponectin in obesity related non-alcoholic fatty liver disease?
Finelli, C. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i6.802 · Cited by 184 · see citing works
Advances in Understanding of the Role of Lipid Metabolism in Aging
Chung, K. W. (2021) · Cells · doi:10.3390/cells10040880 · Cited by 185 · see citing works
Role of Adiponectin in Central Nervous System Disorders
Bloemer, J., Pinky, P. D., Govindarajulu, M., Hong, H., Judd, R. L., Amin, R., Moore, T., Dhanasekaran, M., Reed, M. N., & Suppiramaniam, V. D. (2018) · Neural Plasticity · doi:10.1155/2018/4593530 · Cited by 182 · see citing works
Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling
Miller, R., Chu, Q., Lay, J. E. L., Scherer, P. E., Ahima, R. S., Kaestner, K. H., Foretz, M., Viollet, B., & Birnbaum, M. J. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45942 · Cited by 178 · see citing works
Inter‐organ communication: a gatekeeper for metabolic health
Castillo‐Armengol, J., Fajas, L., & Lopez‐Mejia, I. C. (2019) · The EMBO Reports · doi:10.15252/embr.201947903 · Cited by 178 · see citing works
AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer
Hardie, D. G. (2011) · Biochemical Society Transactions · doi:10.1042/bst0390001 · Cited by 177 · see citing works
The link between abdominal obesity and the metabolic syndrome
Phillips, L. K., & Prins, J. B. (2008) · Current Hypertension Reports · doi:10.1007/s11906-008-0029-7 · Cited by 175 · see citing works
Expression of Adiponectin and Adiponectin Receptors in Human Pituitary Gland and Brain
Psilopanagioti, A., Papadaki, H. H., Kranioti, E. F., Alexandrides, T. K., & Varakis, J. N. (2008) · Neuroendocrinology · doi:10.1159/000151396 · Cited by 171 · see citing works
Adiponectin and energy homeostasis
Lee, B., & Shao, J. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9283-3 · Cited by 171 · see citing works
Adipose Tissue as an Endocrine Organ: An Update on Pro-inflammatory and Anti-inflammatory Microenvironment
Smitka, K., & Maresova, D. (2015) · Prague Medical Report · doi:10.14712/23362936.2015.49 · Cited by 170 · see citing works
AdipoR1 mediates the anorexigenic and insulin/leptin‐like actions of adiponectin in the hypothalamus
Coope, A., Milanski, M., ARAUJO, E. P. D., Tambascia, M. A., Saad, M. J. A., Geloneze, B., & Velloso, L. A. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.03.037 · Cited by 165 · see citing works
Adiponectin receptors are expressed in hypothalamus and colocalized with proopiomelanocortin and neuropeptide Y in rodent arcuate neurons
Guillod-Maximin, E., Roy, A.-F., Vacher, C., Aubourg, A., Bailleux, V., Lorsignol, A., Pénicaud, L., Parquet, M., & Taouis, M. (2008) · Journal of Endocrinology · doi:10.1677/joe-08-0348 · Cited by 163 · see citing works
The Complex Interactions Between Obesity, Metabolism and the Brain
Uranga, R. M., & Keller, J. N. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00513 · Cited by 166 · see citing works
Food Polyphenols and Type II Diabetes Mellitus: Pharmacology and Mechanisms
Naz, R., Saqib, F., Awadallah, S., Wahid, M., Latif, M. F., Iqbal, I. M., & Mubarak, M. (2023) · Molecules · doi:10.3390/molecules28103996 · Cited by 148 · see citing works
Adipose Organ Development and Remodeling
Cinti, S. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170042 · Cited by 187 · see citing works
The brain and brown fat
Contreras, C., González, F., Fernø, J., Diéguez, C., Rahmouni, K., Nogueiras, R., & López, M. (2014) · Annals of Medicine · doi:10.3109/07853890.2014.919727 · Cited by 163 · see citing works
Free radicals and male reproduction.
Agarwal, A. K., & Allamaneni, S. S. R. (2011) · PubMed · Cited by 154 · see citing works
CTRP1 Protein Enhances Fatty Acid Oxidation via AMP-activated Protein Kinase (AMPK) Activation and Acetyl-CoA Carboxylase (ACC) Inhibition*
Peterson, J. M., Aja, S., Wei, Z., & Wong, G. W. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.278333 · Cited by 159 · see citing works
Crosstalk between obesity, diabetes, and alzheimer’s disease: Introducing quercetin as an effective triple herbal medicine
Ebrahimpour, S., Zakeri, M., & Esmaeili, A. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101095 · Cited by 156 · see citing works
Energy sensing by the AMP-activated protein kinase and its effects on muscle metabolism
Hardie, D. G. (2011) · Proceedings of the Nutrition Society · doi:10.1017/s0029665110003915 · Cited by 146 · see citing works
Potential mechanisms of atypical antipsychotic-induced metabolic derangement: Clues for understanding obesity and novel drug design
Coccurello, R., & Moles, A. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.04.008 · Cited by 146 · see citing works
Leptin and the brain: Influences on brain development, cognitive functioning and psychiatric disorders
Farr, O. M., Tsoukas, M. A., & Mantzoros, C. S. (2014) · Metabolism · doi:10.1016/j.metabol.2014.07.004 · Cited by 146 · see citing works
Activation of AMP-Activated Protein Kinase Is Required for Berberine-Induced Reduction of Atherosclerosis in Mice: The Role of Uncoupling Protein 2
Wang, Q., Zhang, M., Liang, B., Shirwany, N. A., Zhu, Y., & Zou, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025436 · Cited by 144 · see citing works
An Update on the Secretory Functions of Brown, White, and Beige Adipose Tissue: Towards Therapeutic Applications
Ghesmati, Z., Rashid, M., Fayezi, S., Gieseler, F., Alizadeh, E., & Darabi, M. (2024) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-023-09850-0 · Cited by 139 · see citing works
β-Hydroxybutyrate: A signaling metabolite in starvation response?
Rojas‐Morales, P., Tapia, E., & Pedraza‐Chaverrí, J. (2016) · Cellular Signalling · doi:10.1016/j.cellsig.2016.04.005 · Cited by 141 · see citing works
Perivascular adipose tissue-derived adiponectin activates BKCa channels to induce anticontractile responses
Lynch, F. M., Withers, S., Yao, Z., Werner, M. E., Edwards, G., Weston, A. H., & Heagerty, A. M. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00697.2012 · Cited by 136 · see citing works
Integrins and Cell Metabolism: An Intimate Relationship Impacting Cancer
Ata, R., & Antonescu, C. N. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18010189 · Cited by 136 · see citing works
Globular adiponectin inhibits GnRH secretion from GT1-7 hypothalamic GnRH neurons by induction of hyperpolarization of membrane potential
Wen, J., Lv, W., Yang, J., Nie, A., Cheng, X., Yang, Y., Ge, Y., Li, X.-Y., & Ning, G. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.04.146 · Cited by 135 · see citing works
Adiponectin Stimulates Proliferation of Adult Hippocampal Neural Stem/Progenitor Cells through Activation of p38 Mitogen-activated Protein Kinase (p38MAPK)/Glycogen Synthase Kinase 3β (GSK-3β)/β-Catenin Signaling Cascade
Zhang, D., Guo, M., Zhang, W., & Lu, X. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.310052 · Cited by 131 · see citing works
Role of the adipose PPARγ-adiponectin axis in susceptibility to stress and depression/anxiety-related behaviors
Guo, M., Li, C., Lei, Y., Xu, S., Zhao, D., & Lu, X.-Y. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.225 · Cited by 131 · see citing works
Regulation of hypothalamic malonyl-CoA by central glucose and leptin
Wolfgang, M. J., Cha, S. H., Sidhaye, A., Chohnan, S., Cline, G., Shulman, G. I., & Lane, M. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709778104 · Cited by 127 · see citing works
Inter‐relationships of the chronobiotic, melatonin, with leptin and adiponectin: implications for obesity
Szewczyk‐Golec, K., Woźniak, A., & Reiter, R. J. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12257 · Cited by 153 · see citing works
Regulation of adiponectin multimerization, signaling and function
Liu, M., & Liu, F. (2014) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2013.06.003 · Cited by 152 · see citing works
Vascular biology of metabolic syndrome
Vykoukal, D. M., & Davies, M. G. (2011) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2011.01.003 · Cited by 129 · see citing works
Niacin stimulates adiponectin secretion through the GPR109A receptor
Plaisance, E. P., Lukasova, M., Offermanns, S., Zhang, Y., Cao, G., & Judd, R. L. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.91004.2008 · Cited by 124 · see citing works

Role of hypothalamic AMP-kinase in food intake regulation
Minokoshi, Y., Shiuchi, T., Lee, S. P., Suzuki, A., & Okamoto, S. (2008) · Nutrition · doi:10.1016/j.nut.2008.06.002 · Cited by 96 · see citing works
Self-citation
The physiological and pathophysiological role of adiponectin and adiponectin receptors in the peripheral tissues and CNS
Kadowaki, T., Yamauchi, T., & Kubota, N. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.11.070 · Cited by 270 · see citing works
Self-citation
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
Minokoshi, Y., Alquier, T., Furukawa, N., Kim, Y.-B., Lee, A., Xue, B., Mu, J., Foufelle, F., Ferré, P., Birnbaum, M. J., et al. (2004) · Nature · doi:10.1038/nature02440 · Cited by 1,637 · see citing works
Self-citation
Dorsal Hindbrain 5′-Adenosine Monophosphate-Activated Protein Kinase as an Intracellular Mediator of Energy Balance
Hayes, M. R., Skibicka, K. P., Bence, K. K., & Grill, H. J. (2008) · Endocrinology · doi:10.1210/en.2008-1319 · Cited by 87 · see citing works
AMP-activated Protein Kinase Plays a Role in the Control of Food Intake
Andersson-Hall, U. K., Filipsson, K., Abbott, C. R., Woods, A., Smith, K. L., Bloom, S. R., Carling, D., & Small, C. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c300557200 · Cited by 756 · see citing works

Authors: Kubota, N., Yano, W., Kubota, T., Yamauchi, T., Itoh, S., Kumagai, H., Kozono, H., Takamoto, I., Okamoto, S., Shiuchi, T., Suzuki, R., Satoh, H., Tsuchida, A., Moroi, M., Sugi, K., Noda, T., Ebinuma, H., Ueta, Y., Kondo, T., Araki, E., Ezaki, O., Nagai, R., Tobe, K., Terauchi, Y., Ueki, K., Minokoshi, Y., & Kadowaki, T.
Affiliations: Japan Science and Technology Agency (JP)
The University of Tokyo (JP)
Toho University (JP)
National Institute for Physiological Sciences (JP)
Tohoku University (JP)
University of Occupational and Environmental Health Japan (JP)
Kumamoto University (JP)
Yokohama City University (JP)
Corresponding author: Kadowaki, Takashi
ORCID: Kubota, Naoto
Yano, Wataru
Kubota, Tetsuya
Yamauchi, Toshimasa
Itoh, Shinsuke
Okamoto, Shiki
Shiuchi, Tetsuya
Suzuki, Ryo
Tsuchida, Atsushi
Moroi, Masao
Ueta, Yoichi
Kondo, Tatsuya
Araki, Eiichi
Ezaki, Osamu
Nagai, Ryozo
Tobe, Kazuyuki
Terauchi, Yasuo
Ueki, Kohjiro
Minokoshi, Yasuhiko
Kadowaki, Takashi
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2007-07
Volume: 6
Issue: 1
Pages: 55-68
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2007.06.003
OpenAlex: W2128485668
Cited by: 844
References: 37
Citations by year: 2026: 24 · 2025: 26 · 2024: 26 · 2023: 46 · 2022: 36 · 2021: 54 · 2020: 37 · 2019: 36 · 2018: 42 · 2017: 34 · 2016: 59 · 2015: 31 · 2014: 56 · 2013: 54 · 2012: 53
FWCI: 22.05
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2208 d)
Locations: Cell Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: Ministry of Education, Culture, Sports, Science and Technology
Ministry of Health and Welfare
Juvenile Diabetes Research Foundation International (1-2003-746)
Daiichi Sankyo Foundation of Life Science
Astellas Foundation for Research on Metabolic Disorders
Kanae Foundation for the Promotion of Medical Science
Japan Society for the Promotion of Science (10NP0201)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords: adiponectin, AMPK, arcuate nucleus, hypothalamus, dietary intake, energy expenditure, AdipoR1, fasting, refeeding, high-fat diet-induced obesity, central nervous system
MeSH terms: Adenoviridae, Animals, Arcuate Nucleus of Hypothalamus, Eating, Energy Metabolism, Female, Hypothalamus, Immunoenzyme Techniques, Male, Mice, Inbred C57BL, Multienzyme Complexes, Phosphorylation, Receptors, Cell Surface, RNA Probes, Protein Serine-Threonine Kinases, In Situ Hybridization, Mice, Knockout, Leptin, Mice, Adiponectin, Adipose Tissue, White, Receptors, Leptin, Receptors, Adiponectin, AMP-Activated Protein Kinases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Adiponectin Stimulates AMP-Activated Protein Kinase in the Hypothalamus and Increases Food Intake

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks