Hofmann, Kay

Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

Meylan, E., Curran, J., Hofmann, K., Moradpour, D., Binder, M., Bartenschlager, R., & Tschopp, J. (2005) · Nature

interferon and immune responsesImmune Response and Inflammation

Cited by 2,401

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

Kazlauskaite, A., Kondapalli, C., Gourlay, R., Campbell, D. G., Ritorto, M. S., Hofmann, K., Alessi, D. R., Knebel, A., Trost, M., & Muqit, M. M. K. (2014) · Biochemical Journal

Parkinson's Disease Mechanisms and TreatmentsUbiquitin and proteasome pathways

Cited by 806

A superfamily of conserved domains in DNA damage‐ responsive cell cycle checkpoint proteins

Bork, P., Hofmann, K., Bucher, P., Neuwald, A. F., Altschul, S. F., & Koonin, E. V. (1997) · The FASEB Journal

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 746

Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis.

Bienko, M., Green, C. M., Crosetto, N., Rudolf, F., Zapart, G., Coull, B., Kannouche, P., Wider, G., Peter, M., Lehmann, A. R., et al. (2005) · Science

DNA Repair MechanismsUbiquitin and proteasome pathways

Cited by 712

Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion

Wang, Y., Okamoto, M., Schmitz, F., Hofmann, K., & Südhof, T. C. (1997) · Nature

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 684

Selective autophagy: ubiquitin-mediated recognition and beyond

Kraft, C., Peter, M., & Hofmann, K. (2010) · Nature Cell Biology

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 639

A superfamily of membrane-bound O -acyltransferases with implications for Wnt signaling

Hofmann, K. (2000) · Trends in Biochemical Sciences

Wnt/β-catenin signaling in development and cancerLipid metabolism and biosynthesis

Cited by 495

Mammalian Homologues of Caenorhabditis elegans unc-13 Gene Define Novel Family of C2-domain Proteins

Brose, N., Hofmann, K., Hata, Y., & Südhof, T. C. (1995) · Journal of Biological Chemistry

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 412

Vps13D Encodes a Ubiquitin-Binding Protein that Is Required for the Regulation of Mitochondrial Size and Clearance

Anding, A. L., Wang, C., Chang, T.-K., Sliter, D. A., Powers, C. M., Hofmann, K., Youle, R. J., & Baehrecke, E. H. (2018) · Current Biology

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 172

NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control

Wang, B., Hurov, K., Hofmann, K., & Elledge, S. J. (2009) · Genes & Development

DNA Repair MechanismsBRCA gene mutations in cancer

Cited by 172

Chemistry and function of polypeptide hormones

Hofmann, K. (1962) · Annual Review of Biochemistry

Neuropeptides and Animal PhysiologyReceptor Mechanisms and Signaling

Cited by 69

Highly sensitive profiling of CD44+/CD24− breast cancer stem cells by combining global mRNA amplification and next generation sequencing: Evidence for a hyperactive PI3K pathway

Hardt, O., Wild, S., Oerlecke, I., Hofmann, K., Luo, S., Wiencek, Y., Kantelhardt, E., Vess, C., Smith, G. P., Schroth, G. P., et al. (2012) · Cancer Letters

Cancer Cells and MetastasisPI3K/AKT/mTOR signaling in cancer

Cited by 64

ERLIN1/2 scaffolds bridge TMUB1 and RNF170 and restrict cholesterol esterification to regulate the secretory pathway

Veronese, M., Kallabis, S., Kaczmarek, A. T., Das, A., Robers, L., Schumacher, S., Lofrano, A., Brodesser, S., Müller, S., Hofmann, K., et al. (2024) · Life Science Alliance

Cellular transport and secretionCholesterol and Lipid Metabolism

Cited by 8

ERLIN1/2 scaffolds bridge TMUB1 and RNF170 and restrict cholesterol esterification to regulate the secretory pathway

Veronese, M., Kallabis, S., Kaczmarek, A. T., Das, A., Robers, L., Schumacher, S., Lofrano, A., Brodesser, S., Müller, S., Hofmann, K., et al. (2024) · Life Science Alliance

Cellular transport and secretionCholesterol and Lipid Metabolism

Cited by 8

The structural basis for deubiquitination by the fingerless USP-type effector TssM

Hermanns, T., Uthoff, M., Baumann, U., & Hofmann, K. (2024) · Life Science Alliance

Ubiquitin and proteasome pathwaysEnzyme Structure and Function

Cited by 7

The structural basis for deubiquitination by the fingerless USP-type effector TssM

Hermanns, T., Uthoff, M., Baumann, U., & Hofmann, K. (2023) · Life Science Alliance

Ubiquitin and proteasome pathwaysEnzyme Structure and Function

Cited by 7

Reprogramming of bacterial virulence by lysine acetylation

Schmöker, O., Girbardt, B., Schulze, S., Palm, G. J., Berndt, L., Hoppen, J., Kara, N., Schöps, X., Al-Abdulla, R., Garz, K., et al. (2026) · Nature Communications

Ubiquitin and proteasome pathwaysEnzyme Structure and Function

Cited by 2