The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
A superfamily of membrane-bound O -acyltransferases with implications for Wnt signaling
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The porcupine protein plays an important role in the palmitolation of the Wnt proteins, and their secretion is regulated by the wntless or evenness interrupted proteins and the retromer complex.
“The porcupine protein has been shown to play an important role in the palmitolation of the Wnt proteins, and their secretion is regulated by the wntless or evenness interrupted proteins and the retromer complex.11–14”
From Wnt signal transduction pathways (2008) · cites this paper as [14]
Citations
Cites
Wnt Signaling Polarizes an Early C. elegans Blastomere to Distinguish Endoderm from Mesoderm
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Dally cooperates with Drosophila Frizzled 2 to transduce Wingless signalling
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The cell-surface proteoglycan Dally regulates Wingless signalling in Drosophila
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Self-citationA flexible motif search technique based on generalized profiles
Bücher, P., Karplus, K. J., Moeri, N., & Hofmann, K. (1996) · Computers & Chemistry · doi:10.1016/s0097-8485(96)80003-9 · Cited by 316
Self-citation5 Cellular Mechanisms of Wingless/Wnt Signal Transduction
Dierick, H. A., & Bejsovec, A. (1998) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(08)60381-6 · Cited by 170
A colipase fold in the carboxy-terminal domain of the Wnt antagonists – the Dickkopfs
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nessy, an evolutionary conserved gene controlled by Hox proteins during Drosophila embryogenesis
Maurel-Zaffran, C., Chauvet, S., Jullien, N. D., et al. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00105-7 · Cited by 12
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Wnt/β-catenin signaling and disease
Clevers, H., & Nusse, R. (2012) · Cell · doi:10.1016/j.cell.2012.05.012 · Cited by 5,554
Wnt proteins are lipid-modified and can act as stem cell growth factors
Willert, K., Brown, J. D., Danenberg, E., Duncan, A. W., Weissman, I. L., Reya, T., Yates, J. R., & Nusse, R. (2003) · Nature · doi:10.1038/nature01611 · Cited by 2,257
The mechanisms of Hedgehog signalling and its roles in development and disease
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Wnt signal transduction pathways
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Helping Wingless take flight: how WNT proteins are secreted
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Structure and mechanism of human diacylglycerol O-acyltransferase 1
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Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme
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Mutation update for the PORCN gene
Lombardi, M. P., Bulk, S., Celli, J., Lampe, A., Gabbett, M. T., Ousager, L. B., van der Smagt, J. J., Soller, M., Stattin, E.-L., Mannens, M. A. M. M., et al. (2011) · Human Mutation · doi:10.1002/humu.21505 · Cited by 72
Substrate and product complexes reveal mechanisms of Hedgehog acylation by HHAT
Jiang, Y., Benz, T. L., & Long, S. B. (2021) · Science · doi:10.1126/science.abg4998 · Cited by 55
Davis, T. R., Pierce, M. R., Novak, S. X., & Hougland, J. L. (2021) · Open Biology · doi:10.1098/rsob.210080 · Cited by 33
“In their original identification as an enzyme superfamily, MBOATmembers were shown to contain two highly conserved residues, an asparagine or aspartate approximately 40 amino acids distant from an invariant histidine in the enzyme C-terminal [7].”
BackgroundMethodInfluentialGhrelin’s Role as a Major Regulator of Appetite and Its Other Functions in Neuroendocrinology
Lim, C. T., Kola, B., Korbonits, M., & Grossman, A. B. (2010) · Progress in Brain Research · doi:10.1016/s0079-6123(10)82008-4 · Cited by 34
Acylation, a Conductor of Ghrelin Function in Brain Health and Disease
Thomas, A. S., Sassi, M., Angelini, R., Morgan, A. H., & Davies, J. S. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.831641 · Cited by 17
“Other members transfer fatty acids to more complex lipids (Hofmann, 2000; Chang and Magee, 2009).”
Background
Metadata
- Authors
- Hofmann, K.
- Corresponding author
- Hofmann, Kay
- ORCID
- Hofmann, Kay
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 2000-03
- Volume
- 25
- Issue
- 3
- Pages
- 111-112
- ISSN
- 0968-0004 (ISSN-L)
- OpenAlex
- W1971388047
- Cited by
- 495
- References
- 10
- Citations by year
- 2026: 6 · 2025: 17 · 2024: 4 · 2023: 15 · 2022: 19 · 2021: 24 · 2020: 8 · 2019: 22 · 2018: 17 · 2017: 15 · 2016: 39 · 2015: 32 · 2014: 23 · 2013: 27 · 2012: 26
- FWCI
- 2.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Biochemical Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Keywords
- O-acyltransferase, membrane-bound enzyme, enzyme superfamilies, Wnt signaling, lipid modification, protein lipidation
- MeSH terms
- Acyltransferases, Amino Acid Sequence, Animals, Bacterial Proteins, Carrier Proteins, Cell Membrane, Sterol O-Acyltransferase, Drosophila, Membrane Proteins, Molecular Sequence Data, Proto-Oncogene Proteins, Signal Transduction, Sequence Homology, Amino Acid, Membrane Transport Proteins, Drosophila Proteins, Diacylglycerol O-Acyltransferase, Wnt1 Protein
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