Campbell, Jonathan E.

Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist

Willard, F. S., Douros, J. D., Gabe, M. B. N., Showalter, A. D., Wainscott, D. B., Suter, T. M., Capozzi, M. E., van der Velden, W. J. C., Stutsman, C., Cardona, G. R., et al. (2020) · JCI Insight

Diabetes Treatment and ManagementReceptor Mechanisms and Signaling

Cited by 541

SIRT4 is a lysine deacylase that controls leucine metabolism and insulin secretion

Anderson, K. A., Huynh, F. K., Fisher-Wellman, K., Stuart, J. D., Peterson, B. S., Douros, J. D., Wagner, G. R., Thompson, J. W., Madsen, A. S., Green, M. F., et al. (2017) · Cell Metabolism

Sirtuins and Resveratrol in MedicineAutophagy in Disease and Therapy

Cited by 326

Revisiting the Complexity of GLP-1 Action from Sites of Synthesis to Receptor Activation

McLean, B. A., Wong, C. K., Campbell, J. E., Hodson, D. J., Trapp, S., & Drucker, D. J. (2021) · Endocrine Reviews

Diabetes Treatment and ManagementRegulation of Appetite and Obesity

Cited by 289

Targeting the Incretin/Glucagon System With Triagonists to Treat Diabetes

Capozzi, M. E., DiMarchi, R. D., Tschöp, M. H., Finan, B., & Campbell, J. E. (2018) · Endocrine Reviews

Diabetes Treatment and ManagementPancreatic function and diabetes

Cited by 153

GIPR/GLP-1R dual agonist therapies for diabetes and weight loss—chemistry, physiology, and clinical applications

Campbell, J. E., Müller, T. D., Finan, B., DiMarchi, R. D., Tschöp, M. H., & D’Alessio, D. A. (2023) · Cell Metabolism

Diabetes Treatment and ManagementPancreatic function and diabetes

Cited by 149

Targeting the GIPR for obesity: To agonize or antagonize? Potential mechanisms

Campbell, J. E. (2021) · Molecular Metabolism

Regulation of Appetite and ObesityDiabetes Treatment and Management

Cited by 133

GIP mediates the incretin effect and glucose tolerance by dual actions on α cells and β cells

El, K., Gray, S. M., Capozzi, M. E., Knuth, E. R., Jin, E., Svendsen, B., Clifford, A., Brown, J. L., Encisco, S. E., Chazotte, B. M., et al. (2021) · Science Advances

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 132

The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets

El, K., Douros, J. D., Willard, F. S., Novikoff, A., Sargsyan, A., Perez-Tilve, D., Wainscott, D. B., Yang, B., Chen, A., Wothe, D., et al. (2023) · Nature Metabolism

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 118

100 years of glucagon and 100 more

Wewer Albrechtsen, N. J., Holst, J. J., Cherrington, A. D., Finan, B., Gluud, L. L., Dean, E. D., Campbell, J. E., Bloom, S. R., Tan, T. M.-M., Knop, F. K., et al. (2023) · Diabetologia

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 117

Hypothalamic and brainstem glucose-dependent insulinotropic polypeptide receptor neurons employ distinct mechanisms to affect feeding

Adriaenssens, A., Broichhagen, J., de Bray, A., Ast, J., Hasib, A., Jones, B., Tomas, A., Burgos, N. F., Woodward, O., Lewis, J., et al. (2023) · JCI Insight

Regulation of Appetite and ObesityDiabetes Treatment and Management

Cited by 77

Pharmacological antagonism of the incretin system protects against diet-induced obesity

Svendsen, B., Capozzi, M. E., Nui, J., Hannou, S. A., Finan, B., Naylor, J., Ravn, P., D'Alessio, D. A., & Campbell, J. E. (2020) · Molecular Metabolism

Regulation of Appetite and ObesityDiabetes Treatment and Management

Cited by 67

Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems

Yang, B., Gelfanov, V. M., El, K., Chen, A., Rohlfs, R., DuBois, B., Kruse Hansen, A. M., Perez-Tilve, D., Knerr, P. J., D'Alessio, D., et al. (2022) · Molecular Metabolism

Diabetes Treatment and ManagementRegulation of Appetite and Obesity

Cited by 55

GLP1R and GIPR expression and signaling in pancreatic alpha cells, beta cells and delta cells

Shilleh, A. H., Viloria, K., Broichhagen, J., Campbell, J. E., & Hodson, D. J. (2024) · Peptides

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 39