Takashima, Akihiko

Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls

Maruyama, M., Shimada, H., Suhara, T., Shinotoh, H., Ji, B., Maeda, J., Zhang, M.-R., Trojanowski, J. Q., Lee, V. M.-Y., Ono, M., et al. (2013) · Neuron

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 760

Microtubule-associated protein tau is essential for long-term depression in the hippocampus

Kimura, T., Whitcomb, D. J., Jo, J., Regan, P., Piers, T., Heo, S., Brown, C., Hashikawa, T., Murayama, M., Seok, H., et al. (2014) · Philosophical Transactions of the Royal Society B: Biological Sciences

Neuroscience and Neuropharmacology ResearchAlzheimer's disease research and treatments

Cited by 307

Increased levels of granular tau oligomers: An early sign of brain aging and Alzheimer's disease

Maeda, S., Sahara, N., Saito, Y., Murayama, S., Ikai, A., & Takashima, A. (2006) · Neuroscience Research

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 301

Exposure of rat hippocampal neurons to amyloid β peptide (25–35) induces the inactivation of phosphatidyl inositol-3 kinase and the activation of tau protein kinase I/glycogen synthase kinase-3β

Takashima, A., Noguchi, K., Michel, G., Mercken, M., Hoshi, M., Ishiguro, K., & Imahori, K. (1996) · Neuroscience Letters

Alzheimer's disease research and treatmentsProtein Kinase Regulation and GTPase Signaling

Cited by 260

New Insights on How Metals Disrupt Amyloid β-Aggregation and Their Effects on Amyloid-β Cytotoxicity

Yoshiike, Y., Tanemura, K., Murayama, O., Akagi, T., Murayama, M., Sato, S., Sun, X., Tanaka, N., & Takashima, A. (2001) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsPrion Diseases and Protein Misfolding

Cited by 244

Hyperphosphorylated tau in parahippocampal cortex impairs place learning in aged mice expressing wild‐type human tau

Kimura, T., Yamashita, S., Fukuda, T., Park, J., Murayama, M., Mizoroki, T., Yoshiike, Y., Sahara, N., & Takashima, A. (2007) · The EMBO Journal

Alzheimer's disease research and treatmentsMemory and Neural Mechanisms

Cited by 144

Tau oligomerization: a role for tau aggregation intermediates linked to neurodegeneration

Sahara, N., Maeda, S., & Takashima, A. (2008) · Current Alzheimer Research

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 99

Methylene Blue Inhibits Formation of Tau Fibrils but not of Granular Tau Oligomers: A Plausible Key to Understanding Failure of a Clinical Trial for Alzheimer’s Disease

Soeda, Y., Saito, M., Maeda, S., Ishida, K., Nakamura, A., Kojima, S., & Takashima, A. (2019) · Journal of Alzheimer’s Disease

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 84

Anesthesia-Induced Hyperphosphorylation Detaches 3-Repeat Tau from Microtubules without Affecting Their Stability In Vivo

Planel, E., Krishnamurthy, P., Miyasaka, T., Liu, L., Herman, M., Kumar, A., Bretteville, A., Figueroa, H. Y., Haung Yu, W., Whittington, R. A., et al. (2008) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsAnesthesia and Neurotoxicity Research

Cited by 79

Distribution of endogenous normal tau in the mouse brain

Kubo, A., Misonou, H., Matsuyama, M., Nomori, A., Wada‐Kakuda, S., Takashima, A., Kawata, M., Murayama, S., Ihara, Y., & Miyasaka, T. (2019) · Journal of Comparative Neurology

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 57

Microtubule destruction induces tau liberation and its subsequent phosphorylation

Miyasaka, T., Sato, S., Tatebayashi, Y., & Takashima, A. (2010) · FEBS Letters

Alzheimer's disease research and treatmentsMicrotubule and mitosis dynamics

Cited by 41

Hyperphosphorylated tau is a cause of neuronal dysfunction in tauopathy

Takashima, A. (2008) · Journal of Alzheimer s Disease

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 40

Tau Oligomers

Maeda, S., & Takashima, A. (2019) · Advances in Experimental Medicine and Biology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 22