Cairns, Nigel J.

Distinct cytokine profiles in human brains resilient to Alzheimer's pathology

Barroeta-Espar, I., Weinstock, L. D., Perez-Nievas, B. G., Meltzer, A. C., Siao Tick Chong, M., Amaral, A. C., Murray, M. E., Moulder, K. L., Morris, J. C., Cairns, N. J., et al. (2019) · Neurobiology of Disease

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 133

APOE genotype and early β-amyloid accumulation in older adults without dementia

Lim, Y. Y., Mormino, E. C., Initiative, F. T. A. D. N., Initiative, A. D. N., Weiner, M., Aisen, P., Weiner, M., Aisen, P., Petersen, R., Jack, C. R., et al. (2017) · Neurology

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 125

Neurological manifestations of autosomal dominant familial Alzheimer’s disease: a comparison of the published literature with the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS)

Tang, M., Ryman, D. C., McDade, E., Jasielec, M. S., Buckles, V. D., Cairns, N. J., Fagan, A. M., Goate, A., Marcus, D. S., Xiong, C., et al. (2016) · The Lancet Neurology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 121

Non-coding variability at the APOE locus contributes to the Alzheimer’s risk

Zhou, X., Chen, Y., Mok, K. Y., Kwok, T. C. Y., Mok, V. C. T., Guo, Q., Ip, F. C., Chen, Y., Mullapudi, N., Initiative, A. D. N., et al. (2019) · Nature Communications

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 120

A comprehensive resource for induced pluripotent stem cells from patients with primary tauopathies

Karch, C. M., Kao, A. W., Karydas, A., Onanuga, K., Martinez, R., Argouarch, A., Wang, C., Huang, C., Sohn, P. D., Bowles, K. R., et al. (2019) · Stem Cell Reports

Alzheimer's disease research and treatmentsPluripotent Stem Cells Research

Cited by 119

The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory

Franzmeier, N., Rubinski, A., Neitzel, J., Ewers, M., (ADNI), T. A. D. N. I., Weiner, M. W., Aisen, P., Petersen, R., Jack, C. R., Jagust, W., et al. (2019) · Nature Communications

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 109

Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy

Yanamandra, K., Patel, T. K., Jiang, H., Schindler, S., Ulrich, J. D., Boxer, A. L., Miller, B. L., Kerwin, D. R., Gallardo, G., Stewart, F., et al. (2017) · Science Translational Medicine

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 100

Genetic Heterogeneity in Alzheimer Disease and Implications for Treatment Strategies

Dominantly Inherited Alzheimer Network, Ringman, J. M., Goate, A., Masters, C. L., Cairns, N. J., Danek, A., Graff-Radford, N., Ghetti, B., & Morris, J. C. (2014) · Current Neurology and Neuroscience Reports

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 96

Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer’s disease pathogenesis

Zhou, X., Chen, Y., Mok, K. Y., Zhao, Q., Chen, K., Chen, Y., Hardy, J., Li, Y., Fu, A. K. Y., Guo, Q., et al. (2018) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 96

Decreased brain levels of 2′,3′-cyclic nucleotide-3′-phosphodiesterase in Down syndrome and Alzheimer’s disease

Vlkolinský, R., Cairns, N., Fountoulakis, M., & Lubec, G. (2001) · Neurobiology of Aging

Down syndrome and intellectual disability researchAlzheimer's disease research and treatments

Cited by 95

Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSP

Jiang, S., Wen, N., Li, Z., Dube, U., Del Aguila, J., Budde, J., Martinez, R., Hsu, S., Fernandez, M. V., Cairns, N. J., et al. (2018) · Translational Psychiatry

Alzheimer's disease research and treatmentsAmyotrophic Lateral Sclerosis Research

Cited by 73

Autosomal dominant and sporadic late onset Alzheimer's disease share a common in vivo pathophysiology

Morris, J. C., Weiner, M., Xiong, C., Beckett, L., Coble, D., Saito, N., Aisen, P. S., Allegri, R., Benzinger, T. L. S., Berman, S. B., et al. (2022) · Brain

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 68

Human Central Nervous System (CNS) ApoE Isoforms Are Increased by Age, Differentially Altered by Amyloidosis, and Relative Amounts Reversed in the CNS Compared with Plasma

Baker-Nigh, A. T., Mawuenyega, K. G., Bollinger, J. G., Ovod, V., Kasten, T., Franklin, E. E., Liao, F., Jiang, H., Holtzman, D., Cairns, N. J., et al. (2016) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 54

Molecular Analysis of the Presenilin 1 (S182) Gene in “Sporadic” Cases of Alzheimer's Disease: Identification and Characterisation of Unusual Splice Variants

Anwar, R., Moynihan, T. P., Ardley, H., Brindle, N., Coletta, P. L., Cairns, N., Markham, A. F., & Robinson, P. A. (1996) · Journal of Neurochemistry

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 30

Towards cascading genetic risk in Alzheimer’s disease

Altmann, A., Aksman, L. M., Oxtoby, N. P., Young, A. L., ADNI, Weiner, M., Aisen, P., Petersen, R., Weiner, M., Aisen, P., et al. (2024) · Brain

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 18