Witters, Lee A.

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

Shaw, R. J., Kosmatka, M., Bardeesy, N., Hurley, R. L., Witters, L. A., DePinho, R. A., & Cantley, L. C. (2004) · Proceedings of the National Academy of Sciences

Metabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancer

Cited by 1,797

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

Brugarolas, J., Lei, K., Hurley, R. L., Manning, B. D., Reiling, J. H., Hafen, E., Witters, L. A., Ellisen, L. W., & Kaelin, W. G. (2004) · Genes & Development

PI3K/AKT/mTOR signaling in cancerCancer, Hypoxia, and Metabolism

Cited by 1,384

Mammalian AMP-activated protein kinase subfamily

Stapleton, D., Mitchelhill, K. I., Gao, G., Widmer, J., Michell, B. J., Teh, T., House, C. M., Fernandez, C. S., Cox, T., Witters, L. A., et al. (1996) · Journal of Biological Chemistry

Metabolism, Diabetes, and CancerBiochemical and Molecular Research

Cited by 652

Metabolic stress and altered glucose transport: activation of AMP-activated protein kinase as a unifying coupling mechanism.

Hayashi, T., Hirshman, M. F., Fujii, N., Habinowski, S. A., Witters, L. A., & Goodyear, L. J. (2000) · Diabetes

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 447

AMPK β Subunit Targets Metabolic Stress Sensing to Glycogen

Polekhina, G., Gupta, A., Michell, B. J., van Denderen, B., Murthy, S., Feil, S. C., Jennings, I. G., Campbell, D. J., Witters, L. A., Parker, M. W., et al. (2003) · Current Biology

Metabolism, Diabetes, and CancerGlycogen Storage Diseases and Myoclonus

Cited by 423

Contraction-induced Changes in Acetyl-CoA Carboxylase and 5′-AMP-activated Kinase in Skeletal Muscle

Vavvas, D., Apazidis, A., Saha, A. K., Gamble, J., Patel, A., Kemp, B. E., Witters, L. A., & Ruderman, N. B. (1997) · Journal of Biological Chemistry

Metabolism, Diabetes, and CancerCancer, Lipids, and Metabolism

Cited by 395

Hypothalamic CaMKK2 Contributes to the Regulation of Energy Balance

Anderson, K. A., Ribar, T. J., Lin, F., Noeldner, P. K., Green, M. F., Muehlbauer, M. J., Witters, L. A., Kemp, B. E., & Means, A. R. (2008) · Cell Metabolism

Regulation of Appetite and ObesityMetabolism, Diabetes, and Cancer

Cited by 385

A possible linkage between AMP‐activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway

Kimura, N., Tokunaga, C., Dalal, S., Richardson, C., Yoshino, K., Hara, K., Kemp, B. E., Witters, L. A., Mimura, O., & Yonezawa, K. (2003) · Genes to Cells

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 372

Effect of Exercise Intensity on Skeletal Muscle AMPK Signaling in Humans

Chen, Z.-P., Stephens, T. J., Murthy, S., Canny, B. J., Hargreaves, M., Witters, L. A., Kemp, B. E., & McConell, G. K. (2003) · Diabetes

Metabolism, Diabetes, and CancerCardiovascular and exercise physiology

Cited by 369

Exercise induces isoform-specific increase in 5'AMP-activated protein kinase activity in human skeletal muscle

Fujii, N., Hayashi, T., Hirshman, M. F., Smith, J. T., Habinowski, S. A., Kaijser, L., Mu, J., Ljungqvist, O., Birnbaum, M. J., Witters, L. A., et al. (2000) · Biochemical and Biophysical Research Communications

Metabolism, Diabetes, and CancerCardiovascular and exercise physiology

Cited by 351

PPARα is necessary for the lipopenic action of hyperleptinemia on white adipose and liver tissue

Lee, Y., Yu, X., Gonzales, F., Mangelsdorf, D. J., Wang, M.-Y., Richardson, C., Witters, L. A., & Unger, R. H. (2002) · Proceedings of the National Academy of Sciences

Peroxisome Proliferator-Activated ReceptorsRegulation of Appetite and Obesity

Cited by 181

α1-AMP-Activated Protein Kinase Regulates Hypoxia-Induced Na,K-ATPase Endocytosis via Direct Phosphorylation of Protein Kinase Cζ

Gusarova, G. A., Dada, L. A., Kelly, A. M., Brodie, C., Witters, L. A., Chandel, N. S., & Sznajder, J. I. (2009) · Molecular and Cellular Biology

Metabolism, Diabetes, and CancerIon Transport and Channel Regulation

Cited by 118

Chutes and Ladders: the search for protein kinases that act on AMPK

Witters, L. A., Kemp, B. E., & Means, A. R. (2006) · Trends in Biochemical Sciences

Metabolism, Diabetes, and CancerProtein Kinase Regulation and GTPase Signaling

Cited by 115