Chutes and Ladders: the search for protein kinases that act on AMPK
Abstract
AMP-activated protein kinase (AMPK), a key regulator of energy homeostasis in mammalian cells, is, in turn, regulated by long-sought upstream protein kinases (AMPKKs). Following the recent identification of the tumor-suppressor kinase LKB1 as an AMPKK, a broader role for AMPK in metabolic economy has been unveiled by a new body of work from three groups that implicates the Ca(2+)/calmodulin-dependent protein kinase kinases as AMPKKs. We suggest that PKE (protein kinase "energy" or "economy") is now an apt name for this kinase, which regulates both cellular and whole-organism energy homeostasis.
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LKB1 levels increased in the exercise-trained group.
“An increase in the levels of LKB1 (liver kinase B1, STK11)30, an upstream kinase of AMPK31, was observed in the trained group (Fig. 3d,h)”
From Exercise activates AMPK in mouse and human pancreatic islets to decrease senescence (2024) · cites this paper as [31]
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- Authors
- Witters, L. A., Kemp, B. E., & Means, A. R.
- Affiliations
- Dartmouth College (US)
- Commonwealth Scientific and Industrial Research Organisation (AU)
- Duke University (US)
- Corresponding author
- Witters, Lee A.
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 2006-01
- Volume
- 31
- Issue
- 1
- Pages
- 13-16
- ISSN
- 0968-0004 (ISSN-L)
- OpenAlex
- W2081708659
- Cited by
- 115
- References
- 16
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 4 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 4 · 2013: 8 · 2012: 8
- FWCI
- 5.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Trends in Biochemical Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Keywords
- AMPK, LKB1, energy homeostasis, metabolic regulation
- MeSH terms
- AMP-Activated Protein Kinase Kinases, Energy Metabolism, Homeostasis, Models, Biological, Models, Molecular, Multienzyme Complexes, Protein Conformation, Protein Kinases, Protein Serine-Threonine Kinases, Calcium-Calmodulin-Dependent Protein Kinase Kinase, AMP-Activated Protein Kinases
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