Doherty, James J.

Brexanolone (SAGE-547 injection) in post-partum depression: a randomised controlled trial.

Kanes, S., Colquhoun, H., Gunduz-Bruce, H., Raines, S., Arnold, R., Schacterle, A., Doherty, J., Epperson, C. N., Deligiannidis, K. M., Riesenberg, R., et al. (2017) · The Lancet

Maternal Mental Health During Pregnancy and PostpartumTreatment of Major Depression

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Effect of Zuranolone vs Placebo in Postpartum Depression

Deligiannidis, K. M., Meltzer-Brody, S., Gunduz-Bruce, H., Doherty, J., Jonas, J., Li, S., Sankoh, A. J., Silber, C., Campbell, A. D., Werneburg, B., et al. (2021) · JAMA Psychiatry

Maternal Mental Health During Pregnancy and PostpartumTreatment of Major Depression

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Trial of SAGE-217 in Patients with Major Depressive Disorder

Gunduz-Bruce, H., Silber, C., Kaul, I., Rothschild, A. J., Riesenberg, R., Sankoh, A. J., Li, H., Lasser, R., Zorumski, C. F., Rubinow, D. R., et al. (2019) · New England Journal of Medicine

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 232

Zuranolone for the Treatment of Postpartum Depression

Deligiannidis, K. M., Meltzer-Brody, S., Maximos, B., Peeper, E. Q., Freeman, M., Lasser, R., Bullock, A., Kotecha, M., Li, S., Forrestal, F., et al. (2023) · American Journal of Psychiatry

Maternal Mental Health During Pregnancy and PostpartumTreatment of Major Depression

Cited by 192

Stimulus-Specific Adaptation in Auditory Cortex Is an NMDA-Independent Process Distinct from the Sensory Novelty Encoded by the Mismatch Negativity

Farley, B. J., Quirk, M. C., Doherty, J. J., & Christian, E. P. (2010) · The Journal of Neuroscience

Neuroscience and Music PerceptionHearing, Cochlea, Tinnitus, Genetics

Cited by 183

Long-Term Depression in Hippocampal Interneurons: Joint Requirement for Pre- and Postsynaptic Events

Laezza, F., Doherty, J. J., & Dingledine, R. (1999) · Science

Neuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Cited by 157

Open-label, proof-of-concept study of brexanolone in the treatment of severe postpartum depression

Kanes, S. J., Colquhoun, H., Doherty, J., Raines, S., Hoffmann, E., Rubinow, D. R., & Meltzer-Brody, S. (2017) · Human Psychopharmacology: Clinical and Experimental

Maternal Mental Health During Pregnancy and PostpartumTreatment of Major Depression

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Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABAA receptor positive allosteric modulator

Althaus, A. L., Ackley, M. A., Belfort, G. M., Gee, S. M., Dai, J., Nguyen, D. P., Kazdoba, T. M., Modgil, A., Davies, P. A., Moss, S. J., et al. (2020) · Neuropharmacology

Neuroscience and Neuropharmacology ResearchTreatment of Major Depression

Cited by 135

Neuroactive Steroids. 2. 3α-Hydroxy-3β-methyl-21-(4-cyano-1 H -pyrazol-1′-yl)-19-nor-5β-pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric Modulator of the (γ-Aminobutyric Acid) A Receptor

Martinez Botella, G., Salituro, F. G., Harrison, B. L., Beresis, R. T., Bai, Z., Blanco, M.-J., Belfort, G. M., Dai, J., Loya, C. M., Ackley, M. A., et al. (2017) · Journal of Medicinal Chemistry

Neuroscience and Neuropharmacology ResearchHeterocyclic Compound Synthesis and Bioactivity

Cited by 129

25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner

Wong, M. Y., Lewis, M., Doherty, J. J., Shi, Y., Cashikar, A. G., Amelianchik, A., Tymchuk, S., Sullivan, P. M., Qian, M., Covey, D. F., et al. (2020) · Journal of Neuroinflammation

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

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Zuranolone for the Treatment of Adults With Major Depressive Disorder: A Randomized, Placebo‐Controlled Phase 3 Trial

Clayton, A. H., Lasser, R., Parikh, S. V., Iosifescu, D. V., Jung, J., Kotecha, M., Forrestal, F., Jonas, J., Kanes, S. J., & Doherty, J. (2023) · American Journal of Psychiatry

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 87

EEG-β/γ spectral power elevation in rat: a translatable biomarker elicited by GABAAα2/3-positive allosteric modulators at nonsedating anxiolytic doses

Christian, E. P., Snyder, D. H., Song, W., Gurley, D. A., Smolka, J., Maier, D. L., Ding, M., Gharahdaghi, F., Liu, X. F., Chopra, M., et al. (2015) · Journal of Neurophysiology

Neuroscience and Neuropharmacology ResearchNeural dynamics and brain function

Cited by 68

SAGE-217, a novel GABAA receptor positive allosteric modulator: clinical pharmacology and tolerability in randomized phase i dose-finding studies.

Hoffmann, E., Nomikos, G. G., Kaul, I., Raines, S., Wald, J., Bullock, A., Sankoh, A. J., Doherty, J., Kanes, S. J., & Colquhoun, H. (2020) · Clinical Pharmacokinetics

Neuroscience and Neuropharmacology ResearchEpilepsy research and treatment

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