EEG-β/γ spectral power elevation in rat: a translatable biomarker elicited by GABAAα2/3-positive allosteric modulators at nonsedating anxiolytic doses

Parvalbumin neurons and gamma rhythms enhance cortical circuit performance

Sohal, V. S., Zhang, F., Yizhar, O., & Deisseroth, K. (2009) · Nature · doi:10.1038/nature07991 · Cited by 2,606 · see citing works

Driving fast-spiking cells induces gamma rhythm and controls sensory responses

Cardin, J. A., Carlén, M., Meletis, K., Knoblich, U., Zhang, F., Deisseroth, K., Tsai, L.-H., & Moore, C. I. (2009) · Nature · doi:10.1038/nature08002 · Cited by 2,603 · see citing works

Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks

Bartos, M., Vida, I., & Jonas, P. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2044 · Cited by 2,070 · see citing works

Perception's shadow: long-distance synchronization of human brain activity

Rodriguez, E., George, N., Lachaux, J.-P., Martinerie, J., Renault, B., & Varela, F. J. (1999) · Nature · doi:10.1038/17120 · Cited by 1,915 · see citing works

Control of sleep and wakefulness

Brown, R. E., Basheer, R., McKenna, J. T., Strecker, R. E., & McCarley, R. W. (2012) · Physiological Reviews · doi:10.1152/physrev.00032.2011 · Cited by 1,477 · see citing works

Benzodiazepine actions mediated by specific γ-aminobutyric acidA receptor subtypes

Rudolph, U., Crestani, F., Benke, D., Brünig, I., Benson, J. A., Fritschy, J.-M., Martin, J. R., Bluethmann, H., & Möhler, H. (1999) · Nature · doi:10.1038/44579 · Cited by 1,172 · see citing works

The gamma cycle.

Fries, P., Nikolić, D., & Singer, W. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.05.005 · Cited by 1,044 · see citing works

Molecular and neuronal substrate for the selective attenuation of anxiety

Löw, K., Crestani, F., Keist, R., Benke, D., Brünig, I., Benson, J. A., Fritschy, J.-M., Rülicke, T., Bluethmann, H., Möhler, H., et al. (2000) · Science · doi:10.1126/science.290.5489.131 · Cited by 946 · see citing works

Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABAA receptor α1 subtype

McKernan, R. M., Rosahl, T. W., Reynolds, D. S., Sur, C., Wafford, K. A., Atack, J. R., Farrar, S., Myers, J., Cook, G., Ferris, P., et al. (2000) · Nature Neuroscience · doi:10.1038/75761 · Cited by 944 · see citing works

Perisomatic Inhibition

Freund, T. F., & Katona, I. (2007) · Neuron · doi:10.1016/j.neuron.2007.09.012 · Cited by 656 · see citing works

Interneuron Diversity series: Rhythm and mood in perisomatic inhibition

Freund, T. F. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00227-3 · Cited by 641 · see citing works

Animal models for the study of anti-anxiety agents: A review

Treit, D. (1985) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(85)90046-6 · Cited by 449 · see citing works

Reversal of pathological pain through specific spinal GABAA receptor subtypes

Knabl, J., Witschi, R., Hösl, K., Reinold, H., Zeilhofer, U. B., Ahmadi, S., Brockhaus, J., Sergejeva, M., Hess, A., Brune, K., et al. (2008) · Nature · doi:10.1038/nature06493 · Cited by 438 · see citing works

Selective alterations in prefrontal cortical GABA neurotransmission in schizophrenia: a novel target for the treatment of working memory dysfunction

Lewis, D., Volk, D., & Hashimoto, T. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1673-x · Cited by 253 · see citing works

Evidence for a Significant Role of α3-Containing GABA_AReceptors in Mediating the Anxiolytic Effects of Benzodiazepines

Dias, R., Sheppard, W. F. A., Fradley, R. L., Garrett, E. M., Stanley, J. L., Tye, S. J., Goodacre, S., Lincoln, R. J., Cook, S. M., Conley, R., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1166-05.2005 · Cited by 247 · see citing works

Diazepam-induced changes in sleep: Role of the α1 GABA A receptor subtype

Tobler, I., Kopp, C., Deboer, T., & Rudolph, U. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111055398 · Cited by 230 · see citing works

TPA023 [7-(1,1-Dimethylethyl)-6-(2-ethyl-2 H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an Agonist Selective for α2- and α3-Containing GABAA Receptors, Is a Nonsedating Anxiolytic in Rodents and Primates

Atack, J. R., Wafford, K. A., Tye, S. J., Cook, S. M., Sohal, B., Pike, A., Sur, C., Melillo, D., Bristow, L., Bromidge, F., et al. (2006) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.089920 · Cited by 188 · see citing works

Oscillatory Synchrony in the Monkey Temporal Lobe Correlates with Performance in a Visual Short-term Memory Task

Tallon‐Baudry, C. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh031 · Cited by 170 · see citing works

Effects of diazepam and zolpidem on EEG beta frequencies are behavior-specific in rats

van Lier, H., Drinkenburg, W. H. I. M., van Eeten, Y. J. W., & Coenen, A. M. L. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.03.017 · Cited by 164 · see citing works

Modulation of rhythmic brain activity by diazepam: GABA A receptor subtype and state specificity

Kopp, C., Rudolph, U., Löw, K., & Tobler, I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306975101 · Cited by 132 · see citing works

Aligning strategies for using EEG as a surrogate biomarker: A review of preclinical and clinical research

Leiser, S. C., Dunlop, J., Bowlby, M. R., & Devilbiss, D. M. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.10.002 · Cited by 120 · see citing works

Both α2 and α3 GABAA receptor subtypes mediate the anxiolytic properties of benzodiazepine site ligands in the conditioned emotional response paradigm

Morris, H. V., Dawson, G. R., Reynolds, D. S., Atack, J. R., & Stephens, D. N. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04775.x · Cited by 110 · see citing works

Pharmacodynamic and pharmacokinetic effects of MK-0343, a GABA A α 2,3 subtype selective agonist, compared to lorazepam and placebo in healthy male volunteers

de Haas, S. L., de Visser, S. J., Post, J. P. V. D., Schoemaker, R. C., Dyck, K. V., Murphy, M. G., Smet, M. D., Vessey, L. K., Ramakrishnan, R., Xue, L., et al. (2007) · Journal of Psychopharmacology · doi:10.1177/0269881107082108 · Cited by 104 · see citing works

EEG Topography and Tomography (LORETA) in the Classification and Evaluation of the Pharmacodynamics of Psychotropic Drugs

Saletu, B., Anderer, P., & Saletu-Zyhlarz, G. M. (2006) · Clinical EEG and Neuroscience · doi:10.1177/155005940603700205 · Cited by 90 · see citing works

Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling of the Electroencephalogram Effects of GABAA Receptor Modulators: In Vitro-in Vivo Correlations

Visser, S. A. G., Wolters, F. L. C., Gubbens-Stibbe, J. M., Tukker, E., van der Graaf, P. H., Peletier, L. A., & Danhof, M. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.042341 · Cited by 85 · see citing works

Pharmacodynamic and pharmacokinetic effects of TPA023, a GABA _A α _2,3 subtype-selective agonist, compared to lorazepam and placebo in healthy volunteers

de Haas, S. L., de Visser, S. J., van der Post, J. P., de Smet, M., Schoemaker, R. C., Rijnbeek, B., Cohen, A. F., Vega, J. M., Agrawal, N. G. B., Goel, T. V., et al. (2007) · Journal of Psychopharmacology · doi:10.1177/0269881106072343 · Cited by 84 · see citing works

Differences in intrinsic efficacy of benzodiazepines are reflected in their concentration‐EEG effect relationship

Mandema, J. W., Kuck, M. T., & Danhof, M. (1992) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1992.tb14229.x · Cited by 79 · see citing works

Benzodiazepine receptor binding with [3H]-Ro 15-1788

Goeders, N. E., & Kuhar, M. J. (1985) · Life Sciences · doi:10.1016/0024-3205(85)90505-3 · Cited by 77 · see citing works

Diazepam‐induced changes on sleep and the EEG spectrum in mice: role of the α3‐GABAA receptor subtype

Kopp, C., Rudolph, U., Keist, R., & Tobler, I. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02651.x · Cited by 72 · see citing works

Zolpidem: a nonbenzodiazepine hypnotic for treatment of insomnia.

Hoehns, J. D., & Perry, P. J. (1993) · PubMed · Cited by 60 · see citing works

7-(1,1-Dimethylethyl)-6-(2-ethyl-2 H -1,2,4- triazol-3-ylmethoxy)-3-(2-fluorophenyl)- 1,2,4-triazolo[4,3- b ]pyridazine: A Functionally Selective γ-Aminobutyric Acid A (GABA A ) α2/α3-Subtype Selective Agonist That Exhibits Potent Anxiolytic Activity but Is Not Sedating in Animal Models

Carling, R. W., Madin, A., Guiblin, A., Russell, M. G. N., Moore, K. W., Mitchinson, A., Sohal, B., Pike, A. J., Cook, S. M., Ragan, I., et al. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm058034a · Cited by 54 · see citing works

Subtype-Selective GABAA Receptor Modulation Yields a Novel Pharmacological Profile: The Design and Development of TPA023

Atack, J. R. (2009) · Advances in Pharmacology · doi:10.1016/s1054-3589(08)57004-9 · Cited by 52 · see citing works

Development and SAR of functionally selective allosteric modulators of GABAA receptors

Alhambra, C., Becker, C., Blake, T., Chang, A. (.-F., Damewood, J. R., Daniels, T. S., Dembofsky, B. T., Gurley, D. A., Hall, J. E., Herzog, K. J., et al. (2011) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2011.03.035 · Cited by 51 · see citing works

Comparative in vivo and in vitro regional selectivity of central omega (benzodiazepine) site ligands in inhibiting [3H]flumazenil binding in the rat central nervous system.

Bénavidès, J., Peny, B., Durand, A., Arbilla, S., & Scatton, B. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10428-x · Cited by 50 · see citing works

Disrupting the clustering of GABA A receptor α2 subunits in the frontal cortex leads to reduced γ-power and cognitive deficits

Hines, R. M., Hines, D. J., Houston, C. M., Mukherjee, J. T., Haydon, P. G., Tretter, V. E., Smart, T. G., & Moss, S. J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308706110 · Cited by 39 · see citing works

[N-methyl-3H3]AZ10419369 Binding to the 5-HT1B Receptor: In Vitro Characterization and in Vivo Receptor Occupancy

Maier, D. L., Sobotka-Briner, C., Ding, M., Powell, M. E., Jiang, Q., Hill, G. R., Heys, J. R., Elmore, C. S., Pierson, M. E., & Mrzljak, L. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.150722 · Cited by 36 · see citing works

Pharmacological models in healthy volunteers: their use in the clinical development of psychotropic drugs

Gilles, C., & Luthringer, R. (2007) · Journal of Psychopharmacology · doi:10.1177/0269881107077733 · Cited by 34 · see citing works

GABAA-receptor subtypes

Sigel, E., & Kannenberg, K. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)20032-3 · Cited by 32 · see citing works

Pharmacological Dissociation of EEG and Behavior: A Basic Problem in Sleep-Wake Classification

Coenen, A. M. L., & van Luijtelaar, E. L. (1991) · SLEEP · doi:10.1093/sleep/14.5.464 · Cited by 30 · see citing works

Classification of Psychotropic Drugs Based on Pharmaco-electrocorticographic Studies in Vigilance-Controlled Rats

Krijzer, F., Koopman, P., & Olivier, B. (2008) · Neuropsychobiology · doi:10.1159/000119015 · Cited by 29 · see citing works

A Comparison of the 2/3/5 Selective Positive Allosteric Modulators L-838,417 and TPA023 in Preclinical Models of Inflammatory and Neuropathic Pain

Nickolls, S. A., Mace, H., Fish, R. L., Edye, M. E., Gurrell, R., Ivarsson, M., Pitcher, T., Tanimoto-Mori, S., Richardson, D. S., Sweatman, C., et al. (2011) · Advances in Pharmacological Sciences · doi:10.1155/2011/608912 · Cited by 29 · see citing works

Standard Operating Procedure for the Registration and Computer-Supported Evaluation of Pharmaco-EEG Data

Versavel, M., Leonard, J. P., & Herrmann, W. M. (2008) · Neuropsychobiology · doi:10.1159/000119230 · Cited by 25 · see citing works

The influence of diazepam on the electroencephalogram-evoked potential interrelation in rats

Jongsma, M. L. A., van Rijn, C. M., van Egmond, J., van Schaijk, W. J., Sambeth, A., & Coenen, A. M. L. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01496-8 · Cited by 11 · see citing works

An emerging circuit pharmacology of GABAA receptors

Engin, E., Benham, R. S., & Rudolph, U. (2018) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2018.04.003 · Cited by 225 · see citing works

International Union of Basic and Clinical Pharmacology. CVI: GABAA Receptor Subtype- and Function-selective Ligands: Key Issues in Translation to Humans

Sieghart, W., & Savić, M. M. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014449 · Cited by 211 · see citing works

Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABAA receptor positive allosteric modulator

Althaus, A. L., Ackley, M. A., Belfort, G. M., Gee, S. M., Dai, J., Nguyen, D. P., Kazdoba, T. M., Modgil, A., Davies, P. A., Moss, S. J., et al. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108333 · Cited by 135 · see citing works

GABAkines – Advances in the discovery, development, and commercialization of positive allosteric modulators of GABAA receptors

Cerne, R., LIPPA, A. S., Poe, M. M., Smith, J. L., Jin, X., Ping, X., Golani, L. K., Cook, J. M., & Witkin, J. M. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.108035 · Cited by 89 · see citing works

Subtype Selective γ-Aminobutyric Acid Type A Receptor (GABAAR) Modulators Acting at the Benzodiazepine Binding Site: An Update

Maramai, S., Benchekroun, M., Ward, S. E., & Atack, J. R. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b01312 · Cited by 75 · see citing works

Developmental seizures and mortality result from reducing GABAA receptor α2-subunit interaction with collybistin

Hines, R. M., Maric, H., Hines, D. J., Modgil, A., Panzanelli, P., Nakamura, Y., Nathanson, A. J., Cross, A., Deeb, T. Z., Brandon, N., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05481-1 · Cited by 68 · see citing works

Mechanisms underlying the EEG biomarker in Dup15q syndrome

Frohlich, J., Reiter, L. T., Saravanapandian, V., DiStefano, C., Huberty, S., Hyde, C., Chamberlain, S. J., Bearden, C. E., Golshani, P., Andrei Irimia, A., et al. (2019) · Molecular Autism · doi:10.1186/s13229-019-0280-6 · Cited by 64 · see citing works

Pharmacology in translation: the preclinical and early clinical profile of the novel α2/3 functionally selective GABAA receptor positive allosteric modulator PF‐06372865

Nickolls, S. A., Gurrell, R., van Amerongen, G., Kammonen, J., Cao, L., Brown, A. R., Stead, C., Mead, A. N., Watson, C. A., Hsu, C. C., et al. (2017) · British Journal of Pharmacology · doi:10.1111/bph.14119 · Cited by 62 · see citing works

GABAA Receptor Subtypes Regulate Stress-Induced Colon Inflammation in Mice

Seifi, M., Rodaway, S., Rudolph, U., & Swinny, J. D. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.05.033 · Cited by 58 · see citing works

A Pharmacogenetic ‘Restriction-of-Function’ Approach Reveals Evidence for Anxiolytic-Like Actions Mediated by α5-Containing GABAA Receptors in Mice

Behlke, L. M., Foster, R. A., Liu, J., Benke, D., Benham, R. S., Nathanson, A. J., Yee, B. K., Zeilhofer, H. U., Engin, E., & Rudolph, U. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.49 · Cited by 57 · see citing works

Human pharmacology of positive GABA-A subtype-selective receptor modulators for the treatment of anxiety

Chen, X., van Gerven, J., Cohen, A. F., & Jacobs, G. E. (2018) · Acta Pharmacologica Sinica · doi:10.1038/s41401-018-0185-5 · Cited by 56 · see citing works

Evaluation of short interval cortical inhibition and intracortical facilitation from the dorsolateral prefrontal cortex in patients with schizophrenia

Noda, Y., Barr, M. S., Zomorrodi, R., Cash, R. F. H., Farzan, F., Rajji, T. K., Chen, R. E., Daskalakis, Z. J., & Blumberger, D. M. (2017) · Scientific Reports · doi:10.1038/s41598-017-17052-3 · Cited by 43 · see citing works

CNS Target Identification and Validation: Avoiding the Valley of Death or Naive Optimism?

Hutson, P. H., Clark, J. A., & Cross, A. J. (2016) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010716-104624 · Cited by 35 · see citing works

Beta Electroencephalographic Oscillation Is a Potential GABAergic Biomarker of Chronic Peripheral Neuropathic Pain

Teixeira, M. S., Mancini, C., Wicht, C. A., Maestretti, G. I., Küntzer, T., Cazzoli, D., Mouthon, M., Annoni, J., & Chabwine, J. N. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.594536 · Cited by 33 · see citing works

GABAA receptor occupancy by subtype selective GABAAα2,3 modulators: PET studies in humans

Jučaitė, A., Cselényi, Z., Lappalainen, J., McCarthy, D. J., Lee, C., Nyberg, S., Varnäs, K., Stenkrona, P., Halldin, C., Cross, A. J., et al. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4506-4 · Cited by 32 · see citing works

Electropharmacogram of Sceletium tortuosum extract based on spectral local field power in conscious freely moving rats

Dimpfel, W., Schombert, L., & Gericke, N. (2015) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2015.11.036 · Cited by 31 · see citing works

The NIMH ‘Fast-Fail Trials’ (FAST) Initiative: Rationale, Promise, and Progress

Grabb, M. C., Hillefors, M., & Potter, W. Z. (2020) · Pharmaceutical Medicine · doi:10.1007/s40290-020-00343-y · Cited by 28 · see citing works

Involvement of the GABAA receptor α subunit in the mode of action of etifoxine

Mattei, C., Taly, A., Soualah, Z., Saulais, O., Henrion, D., Guérineau, N. C., Verleye, M., & Legros, C. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.04.034 · Cited by 26 · see citing works

Properties of beta oscillations in Dup15q syndrome

Saravanapandian, V., Frohlich, J., Hipp, J. F., Hyde, C., Scheffler, A. W., Golshani, P., Cook, E. H., Reiter, L. T., Şentürk, D., & Jeste, S. (2020) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-020-09326-1 · Cited by 27 · see citing works

Electrical stimulation of the vmPFC serves as a remote control to affect VTA activity and improve depressive-like behavior

Bruchim-Samuel, M., Lax, E., Gazit, T., Friedman, A., Ahdoot, H. L., Bairachnaya, M., Pinhasov, A., & Yadid, G. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.05.016 · Cited by 26 · see citing works

Pharmacological and toxicological effects of Ruta chalepensis L. on experimentally induced seizures and electroencephalographic spectral power in mice

González-Trujano, M. E., Urbina-Trejo, E., Santos-Valencia, F., Villasana‐Salazar, B., Carmona‐Aparicio, L., & Martı́nez-Vargas, D. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.113866 · Cited by 24 · see citing works

Abnormal sleep physiology in children with 15q11.2-13.1 duplication (Dup15q) syndrome

Saravanapandian, V., Nadkarni, D., Hsu, S.-H., Hussain, S. A., Maski, K. P., Golshani, P., Colwell, C. S., Balasubramanian, S., Dixon, A., Geschwind, D. H., et al. (2021) · Molecular Autism · doi:10.1186/s13229-021-00460-8 · Cited by 23 · see citing works

Cortical and subcortical gamma amino acid butyric acid deficits in anxiety and stress disorders: Clinical implications

Goddard, A. W. (2016) · World Journal of Psychiatry · doi:10.5498/wjp.v6.i1.43 · Cited by 24 · see citing works

Differential effects of the novel neurosteroid hypnotic (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile on electroencephalogram activity in male and female rats

Joksimovic, S. M., Sampath, D., Krishnan, K., Covey, D. F., Jevtović‐Todorović, V., Raol, Y. H., & Todorovic, S. M. (2021) · British Journal of Anaesthesia · doi:10.1016/j.bja.2021.03.029 · Cited by 21 · see citing works

Progress in the discovery of small molecule modulators of the Cys-loop superfamily receptors

Sparling, B. A., & DiMauro, E. F. (2017) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2017.04.073 · Cited by 20 · see citing works

Glutamatergic and GABAergic Receptor Modulation Present Unique Electrophysiological Fingerprints in a Concentration-Dependent and Region-Specific Manner

Gonzalez-Burgos, I., Bainier, M., Gross, S., Schoenenberger, P., Ochoa, J. Á., Valencia, M., & Redondo, R. L. (2023) · eNeuro · doi:10.1523/eneuro.0406-22.2023 · Cited by 17 · see citing works

Spatial–temporal patterns of electrocorticographic spectral changes during midazolam sedation

Nishida, M., Zestos, M. M., & Asano, E. (2015) · Clinical Neurophysiology · doi:10.1016/j.clinph.2015.10.044 · Cited by 17 · see citing works

Effects of Diazepam on Low-Frequency and High-Frequency Electrocortical γ-Power Mediated by α1- and α2-GABAA Receptors

Hofmann, J. I., Schwarz, C., Rudolph, U., & Antkowiak, B. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20143486 · Cited by 16 · see citing works

Non-sedative cortical EEG signatures of allopregnanolone and functional comparators

Lambert, P. M., Ni, R., Benz, A. M., Rensing, N. R., Wong, M., Zorumski, C. F., & Mennerick, S. J. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01450-x · Cited by 15 · see citing works

Evaluation of the anti-conflict, reinforcing, and sedative effects of YT-III-31, a ligand functionally selective for α3 subunit-containing GABA A receptors

Meng, Z., Berro, L. F., Sawyer, E. K., Rüedi‐Bettschen, D., Cook, J. E., Li, G., Platt, D. M., Cook, J. M., & Rowlett, J. K. (2019) · Journal of Psychopharmacology · doi:10.1177/0269881119882803 · Cited by 15 · see citing works

Spectral power and theta-gamma coupling in the basolateral amygdala related with methamphetamine conditioned place preference in mice

Nukitram, J., Cheaha, D., & Kumarnsit, E. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.135939 · Cited by 14 · see citing works

TP003 is a non-selective benzodiazepine site agonist that induces anxiolysis via α2GABAA receptors

Neumann, E., Ralvenius, W. T., Acuña, M. A., Rudolph, U., & Zeilhofer, H. U. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.09.026 · Cited by 14 · see citing works

Tabernaemontana arborea and ibogaine induce paroxysmal EEG activity in freely moving mice: Involvement of serotonin 5-HT1A receptors

González-Trujano, M. E., Krengel, F., Reyes‐Chilpa, R., Villasana‐Salazar, B., González-Gómez, J. D., Santos-Valencia, F., Urbina-Trejo, E., Martínez, A., & Martı́nez-Vargas, D. (2022) · NeuroToxicology · doi:10.1016/j.neuro.2022.01.002 · Cited by 13 · see citing works

EEG Beta functional connectivity decrease in the left amygdala correlates with the affective pain in fibromyalgia: A pilot study

Makowka, S., Mory, L.-N., Mouthon, M., Mancini, C., Guggisberg, A. G., & Chabwine, J. N. (2023) · PLoS ONE · doi:10.1371/journal.pone.0281986 · Cited by 12 · see citing works

Protein complexes as psychiatric and neurological drug targets

Kato, A., & Witkin, J. M. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.01.018 · Cited by 11 · see citing works

Psychophysiological Effects of Zembrin®Using Quantitative EEG Source Density in Combination with Eye-Tracking in 60 Healthy Subjects. A Double-Blind, Randomized, Placebo-Controlled, 3-Armed Study with Parallel Design

Dimpfel, W., Gericke, N., Suliman, S., & Dipah, G. N. C. (2016) · Neuroscience &amp Medicine · doi:10.4236/nm.2016.73013 · Cited by 11 · see citing works

The Search for a Subtype-Selective PET Imaging Agent for the GABA A Receptor Complex: Evaluation of the Radiotracer [ 11 C]ADO in Nonhuman Primates

Lin, S.-F., Bois, F., Holden, D., Nabulsi, N., Pracitto, R., Gao, H., Kapinos, M., Teng, J.-K., Shirali, A. R., Ropchan, J. R., et al. (2017) · Molecular Imaging · doi:10.1177/1536012117731258 · Cited by 11 · see citing works

Alprazolam-induced EEG spectral power changes in rhesus monkeys: a translational model for the evaluation of the behavioral effects of benzodiazepines

Berro, L. F., Overton, J. S., Reeves-Darby, J. A., & Rowlett, J. K. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05793-z · Cited by 11 · see citing works

Atypical electrophysiological and behavioral responses to diazepam in a leading mouse model of Down syndrome

Victorino, D. B., Pinheiro, D. J. L. L., Scott-McKean, J. J., Barker, S., Stasko, M. R., Faber, J., Scorza, C. A., & Costa, A. C. S. (2021) · Scientific Reports · doi:10.1038/s41598-021-89011-y · Cited by 11 · see citing works

Pharmaco-EEG analysis of ligands varying in selectivity for α1 subunit-containing GABAA receptors during the active phase in rats

Reeves-Darby, J. A., Berro, L. F., Platt, D. M., Rüedi‐Bettschen, D., Shaffery, J. P., & Rowlett, J. K. (2023) · Psychopharmacology · doi:10.1007/s00213-023-06450-3 · Cited by 10 · see citing works

Effect of Zembrin® on Brain Electrical Activity in 60 Older Subjects after 6 Weeks of Daily Intake. A Prospective, Randomized, Double-Blind, Placebo-Controlled, 3-Armed Study in a Parallel Design

Dimpfel, W., Gericke, N., Suliman, S., & Dipah, G. N. C. (2017) · World Journal of Neuroscience · doi:10.4236/wjns.2017.71011 · Cited by 10 · see citing works

Synthesis of C‐14 labeled GABAA α2/α3 selective partial agonists and the investigation of late‐occurring and long‐circulating metabolites of GABAA receptor modulator AZD7325

Artelsmair, M., Gu, C., Lewis, R. J., & Elmore, C. S. (2018) · Journal of Labelled Compounds and Radiopharmaceuticals · doi:10.1002/jlcr.3602 · Cited by 10 · see citing works

Increased sensitivity to psychostimulants and GABAergic drugs in Lsamp-deficient mice

Bregin, A., Mazitov, T., Aug, I., Philips, M., Innos, J., & Vasar, E. (2019) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2019.05.010 · Cited by 9 · see citing works

Tau pathology reprograms glucose metabolism to support cortical hyperexcitability, excitatory/inhibitory imbalance, and sleep loss

Irmen, R. E., Turner, S. M., Snipes, J. A., Schloss, K. H., Wang, X., Williams, H. C., Velmurugan, G. V., Hunt, J. B., Li, J., Sullivan, P. G., et al. (2026) · npj Dementia · doi:10.1038/s44400-025-00054-8 · Cited by 10 · see citing works

Sleep neurophysiology in childhood onset schizophrenia

Markovic, A., Buckley, A. W., Driver, D. I., Broadnax, D. D., Gochman, P., Hoedlmoser, K., Rapoport, J. L., & Tarokh, L. (2020) · Journal of Sleep Research · doi:10.1111/jsr.13039 · Cited by 8 · see citing works

Anxiolytic-like Effects and Quantitative EEG Profile of Palmitone Induces Responses Like Buspirone Rather Than Diazepam as Clinical Drugs

Onofre-Campos, D., González-Trujano, M. E., Moreno-Pérez, G. F., Narváez-González, H. F., González-Gómez, J. D., Villasana‐Salazar, B., & Martı́nez-Vargas, D. (2023) · Molecules · doi:10.3390/molecules28093680 · Cited by 7 · see citing works

Anti-Tremor Action of Subtype Selective Positive Allosteric Modulators of GABAA Receptors in a Rat Model of Essential Tremors

Amrutkar, D. V., Dyhring, T., Jacobsen, T. A., Larsen, J. S., & Sandager‐Nielsen, K. (2020) · The Cerebellum · doi:10.1007/s12311-020-01106-w · Cited by 7 · see citing works

Attaining in vivo selectivity of positive modulation of α3βγ2 GABAA receptors in rats: A hard task!

Batinić, B., Stanković, T., Stephen, M. R., Kodali, R., Tiruveedhula, V. V. N. P. B., Li, G., Scholze, P., Marković, B. D., Obradović, A. L., Ernst, M. C., et al. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.05.014 · Cited by 7 · see citing works

Sustained Inhibition of GABA-AT by OV329 Enhances Neuronal Inhibition and Prevents Development of Benzodiazepine Refractory Seizures

Colmers, P. L. W., Arshad, M. N., Mukherjee, J., Lin, S., Ng, S. F. J., Sarmiere, P. D., Davies, P. A., & Moss, S. J. (2024) · eNeuro · doi:10.1523/eneuro.0137-24.2024 · Cited by 5 · see citing works

Effects of acute administration of 4-allyl-2,6-dimethoxyphenol in mouse models of seizures

Ribeiro, L. R., dos Santos, A. M. F., Guedes, É. D. C., Bezerra, T. L. D. S., de Souza, T. L., Barbosa‐Filho, J. M., de Almeida, R. N., & Salvadori, M. G. D. S. S. (2024) · Epilepsy Research · doi:10.1016/j.eplepsyres.2024.107421 · Cited by 4 · see citing works

Electroencephalography Biomarkers of α5-GABA Positive Allosteric Modulators in Rodents

Mazza, F., Guet-McCreight, A., Prévot, T. D., Valiante, T. A., Sibille, E. L., & Hay, E. (2024) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2024.100435 · Cited by 4 · see citing works

An oral allopregnanolone prodrug bypasses liver metabolism via lymphatic transport enabling bioavailability in animals and humans

Simpson, J. S., Quach, T., Han, S., Hu, L., Trevaskis, N. L., Leong, N. J., Sharma, G., Zheng, D., Paul, S. M., Porter, C. J. H., et al. (2026) · Science Translational Medicine · doi:10.1126/scitranslmed.adu2352 · Cited by 3 · see citing works

The efficacy of zuranolone in postpartum depression and major depressive disorder: a review & number needed to treat (NNT) analysis

Cha, D. S., Kleine, N., Teopiz, K. M., Vincenzo, J. D. D., Ho, R., Galibert, S. L., Samra, A., Zilm, S. P. M., Cha, R. H., d’Andrea, G., et al. (2024) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2023.2298340 · Cited by 4 · see citing works

Antinociceptive effects of Raphanus sativus sprouts involve the opioid and 5-HT 1A serotonin receptors, cAMP/cGMP pathways, and the central activity of sulforaphane

Hernández-Sánchez, L. Y., González-Trujano, M. E., Moreno, D. A., Martı́nez-Vargas, D., Vibrans, H., Hernández-León, A., Dorazco‐González, A., Pellicer, F., & Soto‐Hernández, M. (2024) · Food & Function · doi:10.1039/d3fo05229j · Cited by 3 · see citing works

Classification of Herbal Drug Effects by Discriminant Analysis of Quantitative Human EEG Data

Dimpfel, W. (2019) · Neuroscience &amp Medicine · doi:10.4236/nm.2019.102007 · Cited by 4 · see citing works

The “five-star matrix” for patient-centric drug discovery and development in neuroscience

Pähler, A., O’Connor, E. C., Binch, H., Dudal, S., Gobbi, L. B., Lübbers, T., Olivares‐Morales, A., Sarmiento, R. M. R., Grether, U., Ståhl, M., et al. (2025) · Neuron · doi:10.1016/j.neuron.2025.08.004 · Cited by 3 · see citing works

Enhancing Giant African Land Snail (Archachatina marginata) production with Thymus vulgaris (Lamiaceae) in the south-west region of Cameroon

Merlin, T. G., Jua, J. J., Ngoula, F., & Joseph, T. (2024) · PubVet · doi:10.31533/pubvet.v18n05e1589 · Cited by 2 · see citing works

Electrical brain activity in Centenarians: Neurophysiological EEG markers in resilient brain ageing

Vecchio, F., Pappalettera, C., Cacciotti, A., Frasca, F., Marcon, G., & Rossini, P. M. (2025) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2025.112100 · Cited by 1 · see citing works

Resting-state brain dynamics: insights from oscillatory activity in brain networks

Samogin, J., Zago, S., Tonin, A., Seynaeve, M., de Beukelaar, T. T., Porcaro, C., Marinazzo, D., Arcara, G., & Mantini, D. (2025) · Reviews in the Neurosciences · doi:10.1515/revneuro-2025-0094 · Cited by 1 · see citing works

Enantiomer-specific modulation of GABAA receptors differentially regulates stress-induced dopamine dysregulation

Lilly, K., Mondal, P., Cook, J. M., Perez, S. M., & Lodge, D. J. (2026) · Psychopharmacology · doi:10.1007/s00213-026-07164-y · Cited by 1 · see citing works

Proof of Effectiveness of PASCOFLAIR® in Subjects Suffering from Examination Anxiety Using Quantitative EEG in Combination with Eye-Tracking (EnkephaloVision). A Double-Blind, Randomized, Placebo Controlled, 2-Armed, Phase IV Study in Parallel Design

Dimpfel, W., Dipah, G. N. C., & Suliman, S. (2016) · Pharmacology &amp Pharmacy · doi:10.4236/pp.2016.710050 · Cited by 1 · see citing works

Response to experimental cold-induced pain discloses a resistant category among endurance athletes, with a distinct profile of pain-related behavior and GABAergic EEG markers: a case–control preliminary study

Peier, F., Mouthon, M., Pretto, M. D., & Chabwine, J. N. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1287233 · Cited by 1 · see citing works

Ethanol-induced rapid eye movement sleep suppression in rats: Comparison with subtype-selective GABA A receptor compounds

Reeves-Darby, J. A., Berro, L. F., Hembree, H. L., Shaffery, J. P., Rowlett, J. K., Sharmin, D., Mondal, P., Cook, J. M., & Platt, D. M. (2025) · Journal of Psychopharmacology · doi:10.1177/02698811251344682 · Cited by 1 · see citing works

Biomarker-Based Pharmacological Characterization of ENX-102, a Novel α2/3/5 Subtype-Selective GABAA Receptor Positive Allo-Steric Modulator: Translational Insights from Rodent and Human Studies

Nettesheim, P., Vadodaria, K. C., Vanover, K. E., Borghans, L. G. J. M., Cirauqui, E. A., Brubaker, W., Cunningham, S., Parks, S., Serrats, J., Sudarsan, V., et al. (2025) · Cells · doi:10.3390/cells14201575

Additional file 1 of Abnormal sleep physiology in children with 15q11.2-13.1 duplication (Dup15q) syndrome

Saravanapandian, V., Nadkarni, D., Hsu, S.-H., Hussain, S. A., Maski, K. P., Golshani, P., Colwell, C. S., Balasubramanian, S., Dixon, A., Geschwind, D. H., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15102742

Additional file 3 of Abnormal sleep physiology in children with 15q11.2-13.1 duplication (Dup15q) syndrome

Saravanapandian, V., Nadkarni, D., Hsu, S.-H., Hussain, S. A., Maski, K. P., Golshani, P., Colwell, C. S., Balasubramanian, S., Dixon, A., Geschwind, D. H., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15102748

Additional file 2 of Abnormal sleep physiology in children with 15q11.2-13.1 duplication (Dup15q) syndrome

Saravanapandian, V., Nadkarni, D., Hsu, S.-H., Hussain, S. A., Maski, K. P., Golshani, P., Colwell, C. S., Balasubramanian, S., Dixon, A., Geschwind, D. H., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15102745

Comparison of the Utility of Amplitude–Spectral and Coherence Features of Psychotropic Drugs’ Action on ECoG Signal for Pharmaco-EEG Based Drug Screening in Rats

Sysoev, Y. I., Курмазов, Н. С., Shits, D. D., & Okovityi, S. V. (2026) · Methods and Protocols · doi:10.3390/mps9050123

BindingDB Entry 50009300: Subtype Selective γ-Aminobutyric Acid Type A Receptor (GABA

BindingDB (2021) · UC San Diego · doi:10.7270/q2vd72wn

BindingDB Entry 50002545: Progress in the discovery of small molecule modulators of the Cys-loop superfamily receptors.

BindingDB (2020) · UC San Diego · doi:10.7270/q2mc92nr

Pharmaco-EEG analysis of ligands varying in selectivity for α1 subunit-containing GABAA receptors during the active phase in rats

Reeves-Darby, J. A., Berro, L. F., Platt, D. M., Rüedi‐Bettschen, D., Shaffery, J. P., & Rowlett, J. K. (2023) · Psychopharmacology · doi:10.1007/s00213-023-06450-3 · Cited by 10 · see citing works

Human pharmacology of current and novel gaba(a)-ergic treatments for anxiety

Chen, X. (2017) · Data Archiving and Networked Services (DANS)

Biomarker-Based Pharmacological Characterization of ENX-102, a Novel α2/3/5 Subtype-Selective GABAA Receptor Positive Allo-Steric Modulator: Translational Insights from Rodent and Human Studies

Nettesheim, P., Vadodaria, K. C., Vanover, K. E., Borghans, L. G. J. M., Cirauqui, E. A., Brubaker, W., Cunningham, S., Parks, S., Serrats, J., Sudarsan, V., et al. (2025) · Cells · doi:10.3390/cells14201575

Attaining in vivo selectivity of positive modulation of α3βγ2 GABAA receptors in rats: A hard task!

Batinić, B., Stanković, T., Stephen, M. R., Kodali, R., Tiruveedhula, V. V. N. P. B., Li, G., Scholze, P., Marković, B. D., Obradović, A. L., Ernst, M. C., et al. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.05.014 · Cited by 7 · see citing works

A Pharmacogenetic ‘Restriction-of-Function’ Approach Reveals Evidence for Anxiolytic-Like Actions Mediated by α5-Containing GABAA Receptors in Mice

Behlke, L. M., Foster, R. A., Liu, J., Benke, D., Benham, R. S., Nathanson, A. J., Yee, B. K., Zeilhofer, H. U., Engin, E., & Rudolph, U. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.49 · Cited by 57 · see citing works