Dunaief, Joshua L.

DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration

Kaneko, H., Dridi, S., Tarallo, V., Gelfand, B. D., Fowler, B. J., Cho, W. G., Kleinman, M. E., Ponicsan, S. L., Hauswirth, W. W., Chiodo, V. A., et al. (2011) · Nature

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 601

DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88

Tarallo, V., Hirano, Y., Gelfand, B. D., Dridi, S., Kerur, N., Kim, Y., Cho, W. G., Kaneko, H., Fowler, B. J., Bogdanovich, S., et al. (2012) · Cell

Inflammasome and immune disordersRetinal Diseases and Treatments

Cited by 592

mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice

Zhao, C., Yasumura, D., Li, X., Matthes, M., Lloyd, M., Nielsen, G., Ahern, K., Snyder, M., Bok, D., Dunaief, J. L., et al. (2011) · Journal of Clinical Investigation

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 303

Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration

Hahn, P., Qian, Y., Dentchev, T., Chen, L., Beard, J., Harris, Z. L., & Dunaief, J. L. (2004) · Proceedings of the National Academy of Sciences

Iron Metabolism and DisordersRetinal Development and Disorders

Cited by 264

Iron homeostasis and toxicity in retinal degeneration

He, X., Hahn, P., Iacovelli, J., Wong, R., King, C., Bhisitkul, R., Massaro-Giordano, M., & Dunaief, J. L. (2007) · Progress in Retinal and Eye Research

Iron Metabolism and DisordersRetinal Development and Disorders

Cited by 260

Iron Induced Oxidative Damage As a Potential Factor in Age-Related Macular Degeneration: The Cogan Lecture

Dunaief, J. L. (2006) · Investigative Opthalmology & Visual Science

Retinal Diseases and TreatmentsIron Metabolism and Disorders

Cited by 154

GLP-1 Receptor Agonist NLY01 Reduces Retinal Inflammation and Neuron Death Secondary to Ocular Hypertension

Sterling, J. K., Adetunji, M. O., Guttha, S., Bargoud, A. R., Uyhazi, K. E., Ross, A. G., Dunaief, J. L., & Cui, Q. N. (2020) · Cell Reports

Glaucoma and retinal disordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 148

Receptor for advanced glycation end products and age-related macular degeneration

Howes, K. A., Liu, Y., Dunaief, J. L., Milam, A., Frederick, J. M., Marks, A., & Baehr, W. (2004) · Investigative Opthalmology & Visual Science

Advanced Glycation End Products researchRetinal Diseases and Treatments

Cited by 131

IRON TOXICITY AS A POTENTIAL FACTOR IN AMD

WONG, R. W., RICHA, D. C., HAHN, P., GREEN, W. R., & DUNAIEF, J. L. (2007) · Retina

Retinal Diseases and TreatmentsIron Metabolism and Disorders

Cited by 131

Deletion of autophagy inducer RB1CC1 results in degeneration of the retinal pigment epithelium

Yao, J., Jia, L., Khan, N., Lin, C., Mitter, S. K., Boulton, M. E., Dunaief, J. L., Klionsky, D. J., Guan, J.-L., Thompson, D. A., et al. (2015) · Autophagy

Retinal Diseases and TreatmentsAutophagy in Disease and Therapy

Cited by 130

Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD

Hadziahmetovic, M., Dentchev, T., Song, Y., Haddad, N., He, X., Hahn, P., Pratico, D., Wen, R., Harris, Z. L., Lambris, J. D., et al. (2008) · Investigative Opthalmology & Visual Science

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 121

Age-dependent and gender-specific changes in mouse tissue iron by strain

Hahn, P., Song, Y., Ying, G.-S., He, X., Beard, J., & Dunaief, J. L. (2009) · Experimental Gerontology

Iron Metabolism and DisordersTrace Elements in Health

Cited by 98

Systemic administration of the iron chelator deferiprone protects against light-induced photoreceptor degeneration in the mouse retina

Song, D., Song, Y., Hadziahmetovic, M., Zhong, Y., & Dunaief, J. L. (2012) · Free Radical Biology and Medicine

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 96

Iron levels in human retina: sex difference and increase with age

Hahn, P., Ying, G.-S., Beard, J., & Dunaief, J. L. (2006) · NeuroReport

Iron Metabolism and DisordersTrace Elements in Health

Cited by 90

Generation of Cre Transgenic Mice with Postnatal RPE-Specific Ocular Expression

Iacovelli, J., Zhao, C., Wolkow, N., Veldman, P., Gollomp, K., Ojha, P., Lukinova, N., King, A., Feiner, L., Esumi, N., et al. (2011) · Investigative Opthalmology & Visual Science

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 89

The Multicopper Ferroxidase Hephaestin Enhances Intestinal Iron Absorption in Mice

Fuqua, B. K., Lu, Y., Darshan, D., Frazer, D. M., Wilkins, S. J., Wolkow, N., Bell, A. G., Hsu, J., Yu, C. C., Chen, H., et al. (2014) · PLoS ONE

Iron Metabolism and DisordersTrace Elements in Health

Cited by 88

Neuroprotective effect of intravitreal triamcinolone acetonide against photoreceptor apoptosis in a rabbit model of subretinal hemorrhage

Bhisitkul, R. B., Winn, B. J., Lee, O.-T., Wong, J., Pereira, D. D. S., Porco, T. C., He, X., Hahn, P., & Dunaief, J. L. (2008) · Investigative Opthalmology & Visual Science

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 76

Glucagon-like peptide 1 receptor agonist use is associated with reduced risk for glaucoma

Sterling, J., Hua, P., Dunaief, J. L., Cui, Q. N., & VanderBeek, B. L. (2023) · British Journal of Ophthalmology

Glaucoma and retinal disordersDrug-Induced Ocular Toxicity

Cited by 75

Interleukin-6 triggers toxic neuronal iron sequestration in response to pathological α-synuclein

Sterling, J. K., Kam, T.-I., Guttha, S., Park, H., Baumann, B., Mehrabani-Tabari, A. A., Schultz, H., Anderson, B., Alnemri, A., Chou, S.-C., et al. (2022) · Cell Reports

Parkinson's Disease Mechanisms and TreatmentsNeurological diseases and metabolism

Cited by 58

Iron prochelator BSIH protects retinal pigment epithelial cells against cell death induced by hydrogen peroxide

Charkoudian, L. K., Dentchev, T., Lukinova, N., Wolkow, N., Dunaief, J. L., & Franz, K. J. (2008) · Journal of Inorganic Biochemistry

Iron Metabolism and DisordersMolecular Sensors and Ion Detection

Cited by 49

Mice with hepcidin‐resistant ferroportin accumulate iron in the retina

Theurl, M., Song, D., Clark, E., Sterling, J., Grieco, S., Altamura, S., Galy, B., Hentze, M., Muckenthaler, M. U., & Dunaief, J. L. (2016) · The FASEB Journal

Iron Metabolism and DisordersRetinal Development and Disorders

Cited by 36

Age- and Gene-Dosage–Dependent Cre-Induced Abnormalities in the Retinal Pigment Epithelium

He, L., Marioutina, M., Dunaief, J. L., & Marneros, A. G. (2014) · The American Journal of Pathology

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 26

A High Serum Iron Level Causes Mouse Retinal Iron Accumulation Despite an Intact Blood-Retinal Barrier

Zhao, L., Li, Y., Song, D., Song, Y., Theurl, M., Wang, C., Cwanger, A., Su, G., & Dunaief, J. L. (2014) · The American Journal of Pathology

Iron Metabolism and DisordersRetinal Development and Disorders

Cited by 25