Möbius, Wiebke

Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity

Fünfschilling, U., Supplie, L. M., Mahad, D., Boretius, S., Saab, A. S., Edgar, J., Brinkmann, B. G., Kassmann, C. M., Tzvetanova, I. D., Möbius, W., et al. (2012) · Nature

Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research Studies

Cited by 1,523

Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication

Frühbeis, C., Fröhlich, D., Kuo, W. P., Amphornrat, J., Thilemann, S., Saab, A. S., Kirchhoff, F., Möbius, W., Goebbels, S., Nave, K.-A., et al. (2013) · PLoS Biology

Extracellular vesicles in diseaseCellular transport and secretion

Cited by 902

High cholesterol level is essential for myelin membrane growth

Saher, G., Brügger, B., Lappe-Siefke, C., Möbius, W., Tozawa, R.-I., Wehr, M. C., Wieland, F., Ishibashi, S., & Nave, K.-A. (2005) · Nature Neuroscience

Neurogenesis and neuroplasticity mechanismsCholesterol and Lipid Metabolism

Cited by 799

Oligodendroglial NMDA receptors regulate glucose import and axonal energy metabolism

Saab, A. S., Tzvetavona, I. D., Trevisiol, A., Baltan, S., Dibaj, P., Kusch, K., Möbius, W., Goetze, B., Jahn, H. M., Huang, W., et al. (2016) · Neuron

Neuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

Cited by 590

Defective cholesterol clearance limits remyelination in the aged central nervous system

Cantuti-Castelvetri, L., Fitzner, D., Bosch-Queralt, M., Weil, M.-T., Su, M., Sen, P., Ruhwedel, T., Mitkovski, M., Trendelenburg, G., Lütjohann, D., et al. (2018) · Science

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Cited by 586

Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease

Depp, C., Sun, T., Sasmita, A. O., Spieth, L., Berghoff, S. A., Nazarenko, T., Overhoff, K., Steixner-Kumar, A. A., Subramanian, S., Arinrad, S., et al. (2023) · Nature

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 493

Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis

Berghoff, S. A., Spieth, L., Sun, T., Hosang, L., Schlaphoff, L., Depp, C., Düking, T., Winchenbach, J., Neuber, J., Ewers, D., et al. (2021) · Nature Neuroscience

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 307

The Axon-Myelin Unit in Development and Degenerative Disease

Stassart, R. M., Möbius, W., Nave, K.-A., & Edgar, J. M. (2018) · Frontiers in Neuroscience

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 246

Dietary cholesterol promotes repair of demyelinated lesions in the adult brain

Berghoff, S. A., Gerndt, N., Winchenbach, J., Stumpf, S. K., Hosang, L., Odoardi, F., Ruhwedel, T., Böhler, C., Barrette, B., Stassart, R., et al. (2017) · Nature Communications

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 151

Monitoring ATP dynamics in electrically active white matter tracts

Trevisiol, A., Saab, A. S., Winkler, U., Marx, G., Imamura, H., Möbius, W., Kusch, K., Nave, K.-A., & Hirrlinger, J. (2017) · eLife

Mitochondrial Function and PathologyAdvanced Fluorescence Microscopy Techniques

Cited by 151

Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases

Weil, M.-T., Möbius, W., Winkler, A., Ruhwedel, T., Wrzos, C., Romanelli, E., Bennett, J. L., Enz, L., Goebels, N., Nave, K.-A., et al. (2016) · Cell Reports

Multiple Sclerosis Research StudiesPeripheral Neuropathies and Disorders

Cited by 142

Myelin basic protein‐dependent plasma membrane reorganization in the formation of myelin

Fitzner, D., Schneider, A., Kippert, A., Möbius, W., Willig, K. I., Hell, S. W., Bunt, G., Gaus, K., & Simons, M. (2006) · The EMBO Journal

Lipid Membrane Structure and BehaviorNeurogenesis and neuroplasticity mechanisms

Cited by 135

Inhibition of CNS Remyelination by the Presence of Semaphorin 3A

Syed, Y. A., Hand, E., Möbius, W., Zhao, C., Hofer, M., Nave, K. A., & Kotter, M. R. (2011) · The Journal of Neuroscience

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 134

Oligodendroglial fatty acid metabolism as a central nervous system energy reserve

Asadollahi, E., Trevisiol, A., Saab, A. S., Looser, Z. J., Dibaj, P., Ebrahimi, R., Kusch, K., Ruhwedel, T., Möbius, W., Jahn, O., et al. (2024) · Nature Neuroscience

Lipid metabolism and biosynthesisNeurogenesis and neuroplasticity mechanisms

Cited by 130

Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer’s disease model mice

Sasmita, A. O., Depp, C., Nazarenko, T., Sun, T., Siems, S. B., Ong, E. C., Nkeh, Y. B., Böhler, C., Yu, X., Bues, B., et al. (2024) · Nature Neuroscience

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 125

Therapy of Pelizaeus-Merzbacher disease in mice by feeding a cholesterol-enriched diet

Saher, G., Rudolphi, F., Corthals, K., Ruhwedel, T., Schmidt, K.-F., Löwel, S., Dibaj, P., Barrette, B., Möbius, W., & Nave, K.-A. (2012) · Nature Medicine

Multiple Sclerosis Research StudiesLysosomal Storage Disorders Research

Cited by 123

Survival of adult neurons lacking cholesterol synthesis in vivo

Fünfschilling, U., Saher, G., Xiao, L., Möbius, W., & Nave, K.-A. (2007) · BMC Neuroscience

Cholesterol and Lipid MetabolismCancer, Lipids, and Metabolism

Cited by 120

White matter integrity in mice requires continuous myelin synthesis at the inner tongue

Meschkat, M., Steyer, A. M., Weil, M.-T., Kusch, K., Jahn, O., Piepkorn, L., Agüi-Gonzalez, P., Phan, N. T. N., Ruhwedel, T., Sadowski, B., et al. (2022) · Nature Communications

Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research Studies

Cited by 112

Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease

Schäffner, E., Bosch-Queralt, M., Edgar, J. M., Lehning, M., Strauß, J., Fleischer, N., Kungl, T., Wieghofer, P., Berghoff, S. A., Reinert, T., et al. (2023) · Nature Neuroscience

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 101

Blood-brain barrier hyperpermeability precedes demyelination in the cuprizone model

Berghoff, S. A., Düking, T., Spieth, L., Winchenbach, J., Stumpf, S. K., Gerndt, N., Kusch, K., Ruhwedel, T., Möbius, W., & Saher, G. (2017) · Acta Neuropathologica Communications

Barrier Structure and Function StudiesMultiple Sclerosis Research Studies

Cited by 100

Transport of the major myelin proteolipid protein is directed by VAMP3 and VAMP7

Feldmann, A., Amphornrat, J., Schönherr, M., Winterstein, C., Möbius, W., Ruhwedel, T., Danglot, L., Nave, K.-A., Galli, T., Bruns, D., et al. (2011) · The Journal of Neuroscience

Cellular transport and secretionNeurogenesis and neuroplasticity mechanisms

Cited by 99

Anillin facilitates septin assembly to prevent pathological outfoldings of central nervous system myelin

Erwig, M. S., Patzig, J., Steyer, A. M., Dibaj, P., Heilmann, M., Heilmann, I., Jung, R. B., Kusch, K., Möbius, W., Jahn, O., et al. (2019) · eLife

Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research Studies

Cited by 79

β-Amyloid Peptide Variants in Brains and Cerebrospinal Fluid from Amyloid Precursor Protein (APP) Transgenic Mice

Schieb, H., Kratzin, H., Jahn, O., Möbius, W., Rabe, S., Staufenbiel, M., Wiltfang, J., & Klafki, H. W. (2011) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 65

A role for myelin-associated peroxisomes in maintaining paranodal loops and axonal integrity

Kassmann, C. M., Quintes, S., Rietdorf, J., Möbius, W., Sereda, M. W., Nientiedt, T., Saher, G., Baes, M., & Nave, K.-A. (2011) · FEBS Letters

Hereditary Neurological DisordersMultiple Sclerosis Research Studies

Cited by 52