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Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication

Frühbeis, Carsten, Fröhlich, Dominik, Kuo, Wen Ping, Amphornrat, Jesa, Thilemann, Sebastian, Saab, Aiman S., Kirchhoff, Frank, Möbius, Wiebke +7 more·2013·PLoS Biology
DOI 10.1371/journal.pbio.1001604PMC PMC3706306
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  • Exosomes released by Schwann cells and oligodendrocytes can be taken up by neuronal axons to increase neurite growth, enhance axonal regeneration and improve neuronal survival.

    “Exosomes released by Schwann cells and oligodendrocytes can be taken up by neuronal axons to increase neurite growth, enhance axonal regeneration and improve neuronal survival49,50.”

    From Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity (2017) · cites this paper as [49]

  • EV fusion allows direct retrieval of EV cargo in the cytosol of neurons, avoiding degradation in late endosome or lysosomes, where EVs may accumulate after endocytosis.

    “EV fusion allows direct retrieval of EV cargo in the cytosol of neurons, avoiding degradation in late endosome or lysosomes, where EVs may accumulate after endocytosis [13, 26, 28].”

    From Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations (2018) · cites this paper as [28]

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Authors
Frühbeis, C., Fröhlich, D., Kuo, W. P., Amphornrat, J., Thilemann, S., Saab, A. S., Kirchhoff, F., Möbius, W., Goebbels, S., Nave, K.-A., Schneider, A., Simons, M., Klugmann, M., Trotter, J., & Krämer-Albers, E.-M.
Venue
PLoS Biology
Publisher
Public Library of Science (PLoS)
Published
2013-07-09
Volume
11
Issue
7
Pages
e1001604
ISSN
1545-7885
DOI
10.1371/journal.pbio.1001604
PMC
PMC3706306
Cited by
812
References
9
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (unspecified)

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