Engineered CRISPR-Cas9 nuclease with expanded targeting space

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Molecular replacement with MOLREP

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Rationally engineered Cas9 nucleases with improved specificity

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GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

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Engineered CRISPR-Cas9 nucleases with altered PAM specificities

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Evolved Cas9 variants with broad PAM compatibility and high DNA specificity

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Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems

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Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage

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Engineered Cpf1 variants with altered PAM specificities

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Crystal Structure of Staphylococcus aureus Cas9

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Structural Basis for the Canonical and Non-canonical PAM Recognition by CRISPR-Cpf1

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Structural Plasticity of PAM Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9

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Structural basis for the altered PAM specificities of engineered CRISPR-cas9

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Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors

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Base editing: precision chemistry on the genome and transcriptome of living cells

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CRISPR/Cas Genome Editing and Precision Plant Breeding in Agriculture

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Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants

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Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity

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Applications of CRISPR–Cas in agriculture and plant biotechnology

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CRISPR/Cas9 therapeutics: progress and prospects

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Prime editing for precise and highly versatile genome manipulation

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Past, present, and future of CRISPR genome editing technologies

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CRISPR Gene Therapy: Applications, Limitations, and Implications for the Future

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CRISPR C-to-G base editors for inducing targeted DNA transversions in human cells

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CRISPR/Cas system: recent advances and future prospects for genome editing

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Directed evolution of adenine base editors with increased activity and therapeutic application

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CRISPR-Cas9 DNA Base-Editing and Prime-Editing

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Base editing: advances and therapeutic opportunities

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Evaluation and minimization of Cas9-independent off-target DNA editing by cytosine base editors

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Latest Developed Strategies to Minimize the Off-Target Effects in CRISPR-Cas-Mediated Genome Editing

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CRISPR in cancer biology and therapy

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PnB Designer: a web application to design prime and base editor guide RNAs for animals and plants

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CRISPR-Cas systems: Overview, innovations and applications in human disease research and gene therapy

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Targeted, random mutagenesis of plant genes with dual cytosine and adenine base editors

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The emerging and uncultivated potential of CRISPR technology in plant science

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CRISPR/Cas Systems in Genome Editing: Methodologies and Tools for sgRNA Design, Off‐Target Evaluation, and Strategies to Mitigate Off‐Target Effects

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Precise plant genome editing using base editors and prime editors

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CRISPR/Cas: A powerful tool for gene function study and crop improvement

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Continuous evolution of base editors with expanded target compatibility and improved activity

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Continuous evolution of SpCas9 variants compatible with non-G PAMs

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Gene editing in plants: progress and challenges

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CRISPR/Cas-Mediated Base Editing: Technical Considerations and Practical Applications

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CRISPR DNA base editors with reduced RNA off-target and self-editing activities

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Massively parallel assessment of human variants with base editor screens

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Determinants of Base Editing Outcomes from Target Library Analysis and Machine Learning

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CRISPR technologies and the search for the PAM-free nuclease

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Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors

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Predicting the efficiency of prime editing guide RNAs in human cells

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Precision genome editing in plants: state-of-the-art in CRISPR/Cas9-based genome engineering

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Dual base editor catalyzes both cytosine and adenine base conversions in human cells

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CRISPR technologies for genome, epigenome and transcriptome editing

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Application of the CRISPR/Cas9-based gene editing technique in basic research, diagnosis, and therapy of cancer

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Precise correction of Duchenne muscular dystrophy exon deletion mutations by base and prime editing

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Genome Editing with mRNA Encoding ZFN, TALEN, and Cas9

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Functional interrogation of DNA damage response variants with base editing screens

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Base editing in crops: current advances, limitations and future implications

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CRISPR-Based Adenine Editors Correct Nonsense Mutations in a Cystic Fibrosis Organoid Biobank

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Engineering crops of the future: CRISPR approaches to develop climate-resilient and disease-resistant plants

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Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning

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Recent advances in the CRISPR genome editing tool set

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Design and analysis of CRISPR–Cas experiments

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CRISPR–Act3.0 for highly efficient multiplexed gene activation in plants

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Efficient in vivo genome editing prevents hypertrophic cardiomyopathy in mice

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Prime editing: advances and therapeutic applications

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Prediction of the sequence-specific cleavage activity of Cas9 variants

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Web-based design and analysis tools for CRISPR base editing

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Improving Plant Genome Editing with High-Fidelity xCas9 and Non-canonical PAM-Targeting Cas9-NG

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CRISPR-Cas Tools and Their Application in Genetic Engineering of Human Stem Cells and Organoids

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Engineering of high-precision base editors for site-specific single nucleotide replacement

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CRISPR/Cas: a Nobel Prize award-winning precise genome editing technology for gene therapy and crop improvement

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Base editing correction of hypertrophic cardiomyopathy in human cardiomyocytes and humanized mice

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Genome editing in plants by engineered CRISPR–Cas9 recognizing NG PAM

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Development of CRISPR-Cas systems for genome editing and beyond

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Application of prime editing to the correction of mutations and phenotypes in adult mice with liver and eye diseases

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Mimicking natural polymorphism in eIF 4E by CRISPR ‐Cas9 base editing is associated with resistance to potyviruses

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CRISPR/Cas gene therapy

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In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness

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CRISPR–Cas: a tool for cancer research and therapeutics

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Precision genome editing using cytosine and adenine base editors in mammalian cells

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