Hünig, Thomas

The storm has cleared: lessons from the CD28 superagonist TGN1412 trial

Hünig, T. (2012) · Nature Reviews Immunology

Monoclonal and Polyclonal Antibodies ResearchImmunotoxicology and immune responses

Cited by 194

Efficient expansion of regulatory T cells in vitro and in vivo with a CD28 superagonist

Lin, C., & Hünig, T. (2003) · European Journal of Immunology

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 184

Crystal structure of a soluble CD28-Fab complex

Evans, E. J., Esnouf, R. M., Manso-Sancho, R., Gilbert, R. J. C., James, J. R., Yu, C., Fennelly, J. A., Vowles, C., Hanke, T., Walse, B., et al. (2005) · Nature Immunology

T-cell and B-cell ImmunologyReceptor Mechanisms and Signaling

Cited by 180

CD28‐mediated induction of proliferation in resting T cells in vitro and in vivo without engagement of the T cell receptor: Evidence for functionally distinct forms of CD28

Tacke, M., Hanke, G., Hanke, T., & Hünig, T. (1997) · European Journal of Immunology

T-cell and B-cell ImmunologyMonoclonal and Polyclonal Antibodies Research

Cited by 163

Preculture of PBMCs at high cell density increases sensitivity of T-cell responses, revealing cytokine release by CD28 superagonist TGN1412

Römer, P. S., Berr, S., Avota, E., Na, S.-Y., Battaglia, M., ten Berge, I., Einsele, H., & Hünig, T. (2011) · Blood

T-cell and B-cell ImmunologyImmunotherapy and Immune Responses

Cited by 153

Rapid Regulatory T-Cell Response Prevents Cytokine Storm in CD28 Superagonist Treated Mice

Gogishvili, T., Langenhorst, D., Lühder, F., Elias, F., Elflein, K., Dennehy, K. M., Gold, R., & Hünig, T. (2009) · PLoS ONE

T-cell and B-cell ImmunologyImmunotoxicology and immune responses

Cited by 79

Treatment and prevention of experimental autoimmune neuritis with superagonistic CD28-specific monoclonal antibodies

Schmidt, J., Elflein, K., Stienekemeier, M., Rodriguez-Palmero, M., Schneider, C., Toyka, K. V., Gold, R., & Hünig, T. (2003) · Journal of Neuroimmunology

Multiple Sclerosis Research StudiesPeripheral Neuropathies and Disorders

Cited by 59

Manipulation of regulatory T-cell number and function with CD28-specific monoclonal antibodies

Hünig, T. (2007) · Advances in Immunology

T-cell and B-cell ImmunologyImmunotherapy and Immune Responses

Cited by 57

Type 1 Diabetes in BioBreeding Rats Is Critically Linked to an Imbalance between Th17 and Regulatory T Cells and an Altered TCR Repertoire

van den Brandt, J., Fischer, H. J., Walter, L., Hünig, T., Klöting, I., & Reichardt, H. M. (2010) · The Journal of Immunology

Diabetes and associated disordersT-cell and B-cell Immunology

Cited by 54

The rise and fall of the CD 28 superagonist TGN 1412 and its return as TAB 08: a personal account

Hünig, T. (2016) · The FEBS Journal

T-cell and B-cell ImmunologyMonoclonal and Polyclonal Antibodies Research

Cited by 47

Cell Contact–Dependent Priming and Fc Interaction with CD32+ Immune Cells Contribute to the TGN1412-Triggered Cytokine Response

Bartholomaeus, P., Semmler, L. Y., Bukur, T., Boisguerin, V., Römer, P. S., Tabares, P., Chuvpilo, S., Tyrsin, D. Y., Matskevich, A., Hengel, H., et al. (2014) · The Journal of Immunology

Monoclonal and Polyclonal Antibodies ResearchT-cell and B-cell Immunology

Cited by 40