Efficient expansion of regulatory T cells in vitro and in vivo with a CD28 superagonist

CD4 + CD25 + T cells play a central role in the suppression of autoimmunity and inflammation, making their in vivo expansion a highly attractive therapeutic target. By phenotyping with a novel rat CTL antigen‐4 (CTLA‐4)‐specific monoclonal antibody (mAb) and functional in vitro assays, we here fi…