Heinrich, Peter C.

Principles of interleukin (IL)-6-type cytokine signalling and its regulation

HEINRICH, P. C., BEHRMANN, I., HAAN, S., HERMANNS, H. M., MÜLLER-NEWEN, G., & SCHAPER, F. (2003) · Biochemical Journal

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 3,272

Interleukin-6 and the acute phase response

Heinrich, P. C., Castell, J. V., & Andus, T. (1990) · Biochemical Journal

Cytokine Signaling Pathways and InteractionsAdipokines, Inflammation, and Metabolic Diseases

Cited by 2,734

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

HEINRICH, P. C., BEHRMANN, I., MÜLLER-NEWEN, G., SCHAPER, F., & GRAEVE, L. (1998) · Biochemical Journal

Cytokine Signaling Pathways and InteractionsReceptor Mechanisms and Signaling

Cited by 2,130

Interleukin‐6 is the major regulator of acute phase protein synthesis in adult human hepatocytes

Castell, J. V., Gómez-Lechón, M. J., David, M., Andus, T., Geiger, T., Trullenque, R., Fabra, R., & Heinrich, P. C. (1989) · FEBS Letters

Cytokine Signaling Pathways and InteractionsBiomarkers in Disease Mechanisms

Cited by 893

Association of Transcription Factor APRF and Protein Kinase Jak1 with the Interleukin-6 Signal Transducer gp130

Lütticken, C., Wegenka, U. M., Yuan, J., Buschmann, J., Schindler, C., Ziemiecki, A., Harpur, A. G., Wilks, A. F., Yasukawa, K., Taga, T., et al. (1994) · Science

Cytokine Signaling Pathways and InteractionsNF-κB Signaling Pathways

Cited by 814

SOCS3 Exerts Its Inhibitory Function on Interleukin-6 Signal Transduction through the SHP2 Recruitment Site of gp130

Schmitz, J., Weissenbach, M., Haan, S., Heinrich, P. C., & Schaper, F. (2000) · Journal of Biological Chemistry

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 388

Hepatic acute phase proteins – Regulation by IL-6- and IL-1-type cytokines involving STAT3 and its crosstalk with NF-κB-dependent signaling

Bode, J. G., Albrecht, U., Häussinger, D., Heinrich, P. C., & Schaper, F. (2012) · European Journal of Cell Biology

Cytokine Signaling Pathways and InteractionsNF-κB Signaling Pathways

Cited by 379

Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3

Niemand, C., Nimmesgern, A., Haan, S., Fischer, P., Schaper, F., Rossaint, R., Heinrich, P. C., & Müller-Newen, G. (2003) · The Journal of Immunology

Cytokine Signaling Pathways and InteractionsPsoriasis: Treatment and Pathogenesis

Cited by 357

SHP2 and SOCS3 Contribute to Tyr-759-dependent Attenuation of Interleukin-6 Signaling through gp130

Lehmann, U., Schmitz, J., Weissenbach, M., Sobota, R. M., Hörtner, M., Friederichs, K., Behrmann, I., Tsiaris, W., Sasaki, A., Schneider-Mergener, J., et al. (2003) · Journal of Biological Chemistry

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 236

LPS and TNFα induce SOCS3 mRNA and inhibit IL‐6‐induced activation of STAT3 in macrophages

Bode, J. G., Nimmesgern, A., Schmitz, J., Schaper, F., Schmitt, M., Frisch, W., Häussinger, D., Heinrich, P. C., & Graeve, L. (1999) · FEBS Letters

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 196

Regulation of synthesis and secretion of major rat acute‐phase proteins by recombinant human interleukin‐6 (BSF‐2/1L‐6) in hepatocyte primary cultures

ANDUS, T., GEIGER, T., HIRANO, T., KISHIMOTO, T., TRAN‐THI, T., DECKER, K., & HEINRICH, P. C. (1988) · European Journal of Biochemistry

Cytokine Signaling Pathways and InteractionsLiver physiology and pathology

Cited by 188

Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression

SCHAPER, F., GENDO, C., ECK, M., SCHMITZ, J., GRIMM, C., ANHUF, D., KERR, I. M., & HEINRICH, P. C. (1998) · Biochemical Journal

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 178

A Di-leucine Motif and an Upstream Serine in the Interleukin-6 (IL-6) Signal Transducer gp130 Mediate Ligand-induced Endocytosis and Down-regulation of the IL-6 Receptor

Dittrich, E., Haft, C. R., Muys, L., Heinrich, P. C., & Graeve, L. (1996) · Journal of Biological Chemistry

Cytokine Signaling Pathways and InteractionsCellular transport and secretion

Cited by 160

Soluble interleukin-6 (IL-6) receptor augments central effects of IL-6 in vivo.

Schöbitz, B., Pezeshki, G., Pohl, T., Hemmann, U., Heinrich, P. C., Holsboer, F., & Reul, J. M. H. M. (1995) · The FASEB Journal

Cytokine Signaling Pathways and InteractionsRegulation of Appetite and Obesity

Cited by 159

Expression of suppressors of cytokine signaling during liver regeneration

Campbell, J. S., Prichard, L., Schaper, F., Schmitz, J., Stephenson-Famy, A., Rosenfeld, M. E., Argast, G. M., Heinrich, P. C., & Fausto, N. (2001) · Journal of Clinical Investigation

Cytokine Signaling Pathways and InteractionsLiver physiology and pathology

Cited by 156

Real time analysis of STAT3 nucleocytoplasmic shuttling

Pranada, A. L., Metz, S., Herrmann, A., Heinrich, P. C., & Müller-Newen, G. (2004) · Journal of Biological Chemistry

Cytokine Signaling Pathways and InteractionsAdvanced Fluorescence Microscopy Techniques

Cited by 140

Different protein turnover of interleukin‐6‐type cytokine signalling components

Siewert, E., Müller‐Esterl, W., Starr, R., Heinrich, P. C., & Schaper, F. (1999) · European Journal of Biochemistry

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 121

Mutational analysis of acute-phase response factor/Stat3 activation and dimerization

Sasse, J., Hemmann, U., Schwartz, C., Schniertshauer, U., Heesel, B., Landgraf, C., Schneider-Mergener, J., Heinrich, P. C., & Horn, F. (1997) · Molecular and Cellular Biology

Cytokine Signaling Pathways and InteractionsNF-κB Signaling Pathways

Cited by 120

Nucleocytoplasmic shuttling of persistently activated STAT3

Herrmann, A., Vogt, M., Mönnigmann, M., Clahsen, T., Sommer, U., Haan, S., Poli, V., Heinrich, P. C., & Müller-Newen, G. (2007) · Journal of Cell Science

Cytokine Signaling Pathways and InteractionsNF-κB Signaling Pathways

Cited by 94

The cytoplasmic tyrosine motifs in full-length glycoprotein 130 have different roles in IL-6 signal transduction

Schmitz, J., Dahmen, H., Grimm, C., Gendo, C., Müller-Newen, G., Heinrich, P. C., & Schaper, F. (2000) · The Journal of Immunology

Cytokine Signaling Pathways and InteractionsReceptor Mechanisms and Signaling

Cited by 92

Activation of the Janus kinase/signal transducer and activator of transcription pathway by osmotic shock

Gatsios, P., Terstegen, L., Schliess, F., Häussinger, D., Kerr, I. M., Heinrich, P. C., & Graeve, L. (1998) · Journal of Biological Chemistry

Cytokine Signaling Pathways and InteractionsNF-κB Signaling Pathways

Cited by 85

The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling

FISCHER, P., LEHMANN, U., SOBOTA, R. M., SCHMITZ, J., NIEMAND, C., LINNEMANN, S., HAAN, S., BEHRMANN, I., YOSHIMURA, A., JOHNSTON, J. A., et al. (2004) · Biochemical Journal

Cytokine Signaling Pathways and InteractionsProtein Tyrosine Phosphatases

Cited by 72

Contributions of Leukemia Inhibitory Factor Receptor and Oncostatin M Receptor to Signal Transduction in Heterodimeric Complexes with Glycoprotein 130

Hermanns, H. M., Radtke, S., Haan, C., Schmitz-Van de Leur, H., Tavernier, J., Heinrich, P. C., & Behrmann, I. (1999) · The Journal of Immunology

Cytokine Signaling Pathways and InteractionsReceptor Mechanisms and Signaling

Cited by 71

ME3738 protects from concanavalin A‐induced liver failure via an IL‐6‐dependent mechanism

Klein, C., Wüstefeld, T., Heinrich, P. C., Streetz, K. L., Manns, M. P., & Trautwein, C. (2003) · European Journal of Immunology

Drug-Induced Hepatotoxicity and ProtectionLiver physiology and pathology

Cited by 27