LPS and TNFα induce SOCS3 mRNA and inhibit IL‐6‐induced activation of STAT3 in macrophages

Bode, Johannes G.; Nimmesgern, Ariane; Schmitz, Jochen; Schaper, Fred; Schmitt, Marcus; Frisch, Wiltrud; Häussinger, Dieter; Heinrich, Peter C.; Graeve, Lutz

doi:10.1016/s0014-5793(99)01662-2

Cited by 196Cytokine Signaling Pathways and InteractionsProtein Tyrosine PhosphatasesNF-κB Signaling Pathways

LPS and TNFα induce SOCS3 mRNA and inhibit IL‐6‐induced activation of STAT3 in macrophages

Bode, Johannes G., Nimmesgern, Ariane, Schmitz, Jochen, Schaper, Fred, Schmitt, Marcus, Frisch, Wiltrud, Häussinger, Dieter, Heinrich, Peter C. +1 more·1999·FEBS Letters

DOI 10.1016/s0014-5793(99)01662-2

Open this paper in CoChat — free account

Abstract

Recent findings indicate that cytokine signaling can be modulated by other mediators of simultaneously activated signal transduction pathways. In this study we show that LPS and TNFα are potent inhibitors of IL‐6‐mediated STAT3 activation in human monocyte derived macrophages, rat liver macrophages and RAW 264.7 mouse macrophages but not in human hepatoma cells (HepG2) or in rat hepatocytes. Accordingly, LPS and TNFα were found to induce the expression of SOCS3 mRNA in each of the investigated type of macrophages but not in HepG2 cells. Using a specific inhibitor, evidence is presented that the p38 MAP kinase might be involved, especially for the inhibitory effect of TNFα.

Integrity signals

Registry

Crossref · 10.1016/s0014-5793(99)01662-2

Cites

24 of 31 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Both hepatocytes in vivo and in culture respond to IL-6 treatment in a similar manner, with only STAT-3 homodimers (SIF A) found.
“Moreover, both hepatocytes in vivo and in culture respond to IL-6 treatment in a similar manner; that is, only STAT-3 homodimers (SIF A) are found (unpublished observations and ref. 30).”
From Expression of suppressors of cytokine signaling during liver regeneration (2001) · cites this paper as [30]
In the human hepatoma cell line HepG2, SIF A, B (STAT-3:STAT-1), and C (STAT-1:STAT-1) DNA complexes are all detected after IL-6 treatment.
“One notable exception is the human hepatoma cell line, HepG2 (Figure 1c), where SIF A, B (STAT-3:STAT-1), and C (STAT-1:STAT-1) DNA complexes are all detected after IL-6 treatment (30).”
From Expression of suppressors of cytokine signaling during liver regeneration (2001) · cites this paper as [30]

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
Lee, J. C., Laydon, J. T., McDonnell, P., Gallagher, T. F., Kumar, S., Green, D., McNulty, D. E., Blumenthal, M. J., Keys, J., vatter, S. W. L., et al. (1994) · Nature · doi:10.1038/372739a0 · Cited by 3,266 · see citing works
Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human
Widmann, C., Gibson, S. B., Jarpe, M. B., & Johnson, G. L. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.143 · Cited by 2,707 · see citing works
A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells
Han, J., Lee, J. D., Bibbs, L., & Ulevitch, R. J. (1994) · Science · doi:10.1126/science.7914033 · Cited by 2,647 · see citing works
A rapid micrqpreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells
Andrews, N. C., & Faller, D. V. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.9.2499 · Cited by 2,337 · see citing works
Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine
Raingeaud, J., Gupta, S., Rogers, J. S., Dickens, M., Han, J., Ulevitch, R. J., & Davis, R. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.13.7420 · Cited by 2,244 · see citing works
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
HEINRICH, P. C., BEHRMANN, I., MÜLLER-NEWEN, G., SCHAPER, F., & GRAEVE, L. (1998) · Biochemical Journal · doi:10.1042/bj3340297 · Cited by 2,130 · see citing works
Self-citation
A family of cytokine-inducible inhibitors of signalling
Starr, R., Willson, T. A., Viney, E. M., Murray, L. J. L., Rayner, J. R., Jenkins, B. J., Gonda, T. J., Alexander, W. S., Metcalf, D., Nicola, N. A., et al. (1997) · Nature · doi:10.1038/43206 · Cited by 2,066 · see citing works
The SIF binding element confers sis/PDGF inducibility onto the c‐fos promoter.
Wagner, B. J., Hayes, T. E., Hoban, C. J., & Cochran, B. H. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07898.x · Cited by 592 · see citing works
IL-6 inhibits lipopolysaccharide-induced tumor necrosis factor production in cultured human monocytes, U937 cells, and in mice.
Aderka, D., Le, J., & Vilček, J. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.143.11.3517 · Cited by 577 · see citing works
Acute-Phase Response Factor, a Nuclear Factor Binding to Acute-Phase Response Elements, is Rapidly Activated by Interleukin-6 at the Posttranslational Level
Wegenka, U. M., Buschmann, J., Lütticken, C., Heinrich, P. C., & Horn, F. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.1.276 · Cited by 553 · see citing works
Self-citation
Interleukin-10 Inhibits Expression of Both Interferon – and Interferon γ– Induced Genes by Suppressing Tyrosine Phosphorylation of STAT1
Ito, S., Ansari, P., Sakatsume, M., Dickensheets, H. L., Vazquez, N., Donnelly, R. P., Larner, A. C., & Finbloom, D. S. (1999) · Blood · doi:10.1182/blood.v93.5.1456 · Cited by 389 · see citing works
Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogen-activated protein kinases.
Sengupta, T. K., Talbot, E. S., Scherle, P., & Ivashkiv, L. (1998) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.95.19.11107 · Cited by 245 · see citing works
Stat1 combines signals derived from IFN‐γ and LPS receptors during macrophage activation
Kovarik, P., Stoiber, D., Novy, M., & Decker, T. (1998) · The EMBO Journal · doi:10.1093/emboj/17.13.3660 · Cited by 243 · see citing works
Lipopolysaccharide induces in macrophages the synthesis of the suppressor of cytokine signaling 3 and suppresses signal transduction in response to the activating factor IFN-gamma.
Stoiber, D., Kovarik, P., Cohney, S. J., Johnston, J. A., Steinlein, P., & Decker, T. (1999) · PubMed · Cited by 240 · see citing works
Lipopolysaccharide Induces in Macrophages the Synthesis of the Suppressor of Cytokine Signaling 3 and Suppresses Signal Transduction in Response to the Activating Factor IFN-γ
Stoiber, D., Kovarik, P., Cohney, S. J., Johnston, J. A., Steinlein, P., & Decker, T. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.5.2640 · Cited by 204 · see citing works
Role of anion translocation across the mitochondrial membrane in the regulation of urea synthesis from ammonia by isolated rat hepatocytes.
Meijer, A. J., Gimpel, J. A., Deleeuw, G., Tager, J. M., & WILLIAMSON, J. (1975) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)40876-4 · Cited by 189 · see citing works
Endotoxin-induced cytokine gene expression in vivo. III. IL-6 mRNA and serum protein expression and the in vivo hematologic effects of IL-6
Ulich, T. R., Guo, K., Remick, D. G., del Castillo, J., & Yin, S. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.146.7.2316 · Cited by 150 · see citing works
Rat hepatic sinusoidal endothelial cells in monolayer culture
Eyhorn, S., Schlayer, H. ‐., Henninger, H., Dieter, P., Hermann, R., Woort-Menker, M., Becker, H., Schaefer, H. E., & Decker, K. (1988) · Journal of Hepatology · doi:10.1016/s0168-8278(88)80459-8 · Cited by 144 · see citing works
Single‐step purification and structural characterization of human interleukin‐6 produced in Esherichia coli From a T7 RNA polymerase expression vector
Arcone, R., Pucci, P., Zappacosta, F., Fontaine, V., Malorni, A., Marino, G., & Ciliberto, G. (1991) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1991.tb16048.x · Cited by 136 · see citing works
Inhibition of cytokines and JAK-STAT activation by distinct signaling pathways.
Sengupta, T. K., Schmitt, E. M., & Ivashkiv, L. B. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9499 · Cited by 132 · see citing works
TGF-beta inhibits IL-2-induced tyrosine phosphorylation and activation of Jak-1 and Stat 5 in T lymphocytes
Bright, J. J., Kerr, L. D., & Sriram, S. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.1.175 · Cited by 129 · see citing works
Apoptosis of Neutrophils and Their Elimination by Kupffer Cells in Rat Liver
Shi, J., Fujieda, H., Kokubo, Y., & Wake, K. (1996) · Hepatology · doi:10.1002/hep.510240545 · Cited by 99 · see citing works
Interleukin-6 inhibits the proliferation of B-chronic lymphocytic leukemia cells that is induced by tumor necrosis factor-alpha or -beta
Aderka, D., Maor‬‏, ‪., Novick, D., Engelmann, H., Kahn, Y., Levo, Y., Wallach, D., & Revel, M. (1993) · Blood · doi:10.1182/blood.v81.8.2076.2076 · Cited by 80 · see citing works
Activation of Protein Kinase A Inhibits Interferon Induction of the Jak/Stat Pathway in U266 Cells
David, M., Petricoin, E. F., & Larner, A. C. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.9.4585 · Cited by 74 · see citing works
Mechanism of inhibition of eosinophil activation by transforming growth factor-β. Inhibition of Lyn, MAP, Jak2 kinases and STAT1 nuclear factor
Pazdrak, K., Justement, L. B., & Alam, R. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.9.4454 · Cited by 68 · see citing works
Inhibition of Alpha Interferon but Not Gamma Interferon Signal Transduction by Phorbol Esters Is Mediated by a Tyrosine Phosphatase
Petricoin, E. F., David, M., Igarashi, K., Benjamin, C. D., Ling, L. E., Goelz, S. E., Finbloom, D. S., & Larner, A. C. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.4.1419 · Cited by 44 · see citing works
ATP Depletion Affects the Phosphorylation State, Ligand Binding, and Nuclear Transport of the 4 S Polycyclic Aromatic Hydrocarbon-binding Protein in Rat Hepatoma Cells
Bhat, R., Weaver, J. A., Wagner, C., Bodwell, J. E., & Bresnick, E. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.51.32551 · Cited by 34 · see citing works
Angiotensin II Interferes with Interleukin 6-induced Stat3 Signaling by a Pathway Involving Mitogen-activated Protein Kinase Kinase 1
Bhat, G. J., Abraham, S. T., & Baker, K. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.37.22447 · Cited by 33 · see citing works
Lipopolysaccharide stimulates HepG2 human hepatoma cells in the presence of lipopolysaccharide‐binding protein via CD14
Nanbo, A., Nishimura, H., Muta, T., & Nagasawa, S. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00141.x · Cited by 29 · see citing works
Inhibitory role of interleukin-6 in macrophage proliferation
Riedy, M. C., & Stewart, C. (1992) · Journal of Leukocyte Biology · doi:10.1002/jlb.52.1.125 · Cited by 27 · see citing works
The art and practice of structure-based drug design: A molecular modeling perspective
(1996) · doi:10.1002/(sici)1098-1128(199601)16:1

Flagged first, then by citations

Sorted by citations

Principles of interleukin (IL)-6-type cytokine signalling and its regulation
HEINRICH, P. C., BEHRMANN, I., HAAN, S., HERMANNS, H. M., MÜLLER-NEWEN, G., & SCHAPER, F. (2003) · Biochemical Journal · doi:10.1042/bj20030407 · Cited by 3,272 · see citing works
Self-citation
Role of interleukin-6 in cancer progression and therapeutic resistance
Kumari, N., Dwarakanath, B. S. R., Das, A., & Bhatt, A. N. (2016) · Tumor Biology · doi:10.1007/s13277-016-5098-7 · Cited by 1,096 · see citing works
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages
Yasukawa, H., Ohishi, M., Mori, H., Murakami, M., Chinen, T., Aki, D., Hanada, T., Takeda, K., Akira, S., Hoshijima, M., et al. (2003) · Nature Immunology · doi:10.1038/ni938 · Cited by 771 · see citing works
Regulation of cytokine signaling and inflammation
Hanada, T., & Yoshimura, A. (2002) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(02)00026-6 · Cited by 748 · see citing works
Suppressors of cytokine signaling and immunity
Kubo, M., Hanada, T., & Yoshimura, A. (2003) · Nature Immunology · doi:10.1038/ni1012 · Cited by 614 · see citing works
Biology and significance of the JAK/STAT signalling pathways
Kiu, H., & Nicholson, S. E. (2012) · Growth Factors · doi:10.3109/08977194.2012.660936 · Cited by 470 · see citing works
SOCS3 regulates the plasticity of gp130 signaling
Lang, R., Pauleau, A.-L., Parganas, E., Takahashi, Y., Mages, J., Ihle, J. N., Rutschman, R., & Murray, P. J. (2003) · Nature Immunology · doi:10.1038/ni932 · Cited by 439 · see citing works
Plasticity and cross-talk of Interleukin 6-type cytokines
Garbers, C., Hermanns, H. M., Schaper, F., Müller‐Newen, G., Grötzinger, J., Rose‐John, S., & Scheller, J. (2012) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2012.04.001 · Cited by 401 · see citing works
Self-citation
The macrophage response towards LPS and its control through the p38MAPK–STAT3 axis
Bode, J. G., Ehlting, C., & Häussinger, D. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.01.018 · Cited by 392 · see citing works
Self-citation
Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis
Shouda, T., Yoshida, T., Hanada, T., Wakioka, T., Oishi, M., Miyoshi, K., Komiya, S., Kosai, K.-I., Hanakawa, Y., Hashimoto, K., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13568 · Cited by 394 · see citing works
Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3
Niemand, C., Nimmesgern, A., Haan, S., Fischer, P., Schaper, F., Rossaint, R., Heinrich, P. C., & Müller-Newen, G. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.6.3263 · Cited by 357 · see citing works
Self-citation
Disease-related expression of the IL6/STAT3/SOCS3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis
Li, Y., de Haar, C., Chen, M., Deuring, J., Gerrits, M. M., Smits, R., Xia, B., Kuipers, E. J., & van der Woude, C. J. (2010) · Gut · doi:10.1136/gut.2009.184176 · Cited by 339 · see citing works
IL-6 as a major regulator of MDSC activity and possible target for cancer immunotherapy
Weber, R., Groth, C., Lasser, S., Arkhypov, I., Petrova, V., Altevogt, P., Utikal, J. S., & Umansky, V. (2020) · Cellular Immunology · doi:10.1016/j.cellimm.2020.104254 · Cited by 310 · see citing works
Suppressor of Cytokine Signaling (SOCS) Proteins Indirectly Regulate Toll-like Receptor Signaling in Innate Immune Cells
Baetz, A., Frey, M., Heeg, K. M., & Dalpke, A. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410992200 · Cited by 270 · see citing works
Involvement of Suppressor of Cytokine Signaling-3 as a Mediator of the Inhibitory Effects of IL-10 on Lipopolysaccharide-Induced Macrophage Activation
Berlato, C., Cassatella, M. A., Kinjyo, I., Gatto, L., Yoshimura, A., & Bazzoni, F. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.12.6404 · Cited by 267 · see citing works
Interleukin‐10 targets p38 MAPK to modulate ARE‐dependent TNF mRNA translation and limit intestinal pathology
Kontoyiannis, D. L., Kotlyarov, A., Carballo, E., Alexopoulou, L., Blackshear, P. J., Gaestel, M., Davis, R. J., Flavell, R. A., & Kollias, G. A. (2001) · The EMBO Journal · doi:10.1093/emboj/20.14.3760 · Cited by 255 · see citing works
Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-β1 production
Ogata, H., Chinen, T., Yoshida, T., Kinjyo, I., Takaesu, G., Shiraishi, H., Iida, M., Kobayashi, T., & Yoshimura, A. (2006) · Oncogene · doi:10.1038/sj.onc.1209281 · Cited by 246 · see citing works
Suppressors of Cytokine Signaling (SOCS)-1 and SOCS-3 Are Induced by CpG-DNA and Modulate Cytokine Responses in APCs
Dalpke, A. H., Opper, S., Zimmermann, S., & Heeg, K. M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.12.7082 · Cited by 240 · see citing works
SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis
Wong, P. K. K. (2006) · Journal of Clinical Investigation · doi:10.1172/jci25660 · Cited by 215 · see citing works
Regulation of innate immunity by suppressor of cytokine signaling (SOCS) proteins
Dalpke, A. H., Heeg, K. M., Bartz, H., & Baetz, A. (2007) · Immunobiology · doi:10.1016/j.imbio.2007.10.008 · Cited by 184 · see citing works
SOCS Proteins in Immunity, Inflammatory Diseases, and Immune-Related Cancer
Sobah, M. L., Liongue, C., & Ward, A. C. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.727987 · Cited by 171 · see citing works
Molecular Mechanism of Lipopolysaccharide-Induced SOCS-3 Gene Expression in Macrophages and Microglia
Qin, H., Roberts, K. L., Niyongere, S., Cong, Y., Elson, C. O., & Benveniste, E. N. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.9.5966 · Cited by 168 · see citing works
Negative regulation of cytokine signaling and immune responses by SOCS proteins.
Yoshimura, A., Nishinakamura, H., Matsumura, Y., & Hanada, T. (2005) · Arthritis Research · doi:10.1186/ar1741 · Cited by 162 · see citing works
Expression of suppressors of cytokine signaling during liver regeneration
Campbell, J. S., Prichard, L., Schaper, F., Schmitz, J., Stephenson-Famy, A., Rosenfeld, M. E., Argast, G. M., Heinrich, P. C., & Fausto, N. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11867 · Cited by 156 · see citing works
Self-citation
Neuroinflammatory response to lipopolysaccharide is exacerbated in mice genetically deficient in cyclooxygenase-2
Aïd, S., Langenbach, R. I., & Bosetti, F. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-17 · Cited by 149 · see citing works
Inhibition of IL-6 and IL-10 Signaling and Stat Activation by Inflammatory and Stress Pathways
Ahmed, S. T., & Ivashkiv, L. B. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.9.5227 · Cited by 141 · see citing works
Indirect Inhibition of Toll-like Receptor and Type I Interferon Responses by ITAM-Coupled Receptors and Integrins
Wang, L., Gordon, R. A., Huynh, L., Su, X., Min, K.-H. P., Han, J., Arthur, J. S. C., Kalliolias, G. D., & Ivashkiv, L. B. (2010) · Immunity · doi:10.1016/j.immuni.2010.03.014 · Cited by 140 · see citing works
The roles of SOCS 3 and STAT 3 in bacterial infection and inflammatory diseases
Gao, Y., Zhao, H., Wang, P., Wang, J., & Zou, L. (2018) · Scandinavian Journal of Immunology · doi:10.1111/sji.12727 · Cited by 142 · see citing works
Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-β
Hirotani, T., Yamamoto, M., Kumagai, Y., Uematsu, S., Kawase, I., Takeuchi, O., & Akira, S. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.12.184 · Cited by 135 · see citing works
Interleukin 1 Activates STAT3/Nuclear Factor-κB Cross-talk via a Unique TRAF6- and p65-dependent Mechanism
Yoshida, Y., Kumar, A., Koyama, Y., Peng, H., Arman, A., Boch, J. A., & Auron, P. E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311498200 · Cited by 133 · see citing works
The Contribution of Immune Infiltrates to Ototoxicity and Cochlear Hair Cell Loss
Wood, M. B., & Zuo, J. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00106 · Cited by 127 · see citing works
Regulation of the immune system by SOCS family adaptor proteins
Ilangumaran, S., Ramanathan, S., & Rottapel, R. K. (2004) · Seminars in Immunology · doi:10.1016/j.smim.2004.08.015 · Cited by 127 · see citing works
Hepatitis C Virus Core Protein Induces Cell Proliferation and Activates ERK, JNK, and p38 MAP Kinases Together with the MAP Kinase Phosphatase MKP-1 in a HepG2 Tet-Off Cell Line
Erhardt, A., Hassan, M., Heintges, T., & Häussinger, D. (2002) · Virology · doi:10.1006/viro.2001.1227 · Cited by 121 · see citing works
Self-citation
Interleukins in chronic liver disease: lessons learned from experimental mouse models
Tacke, F., & Hammerich, L. (2014) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s43737 · Cited by 120 · see citing works
Acute-phase protein synthesis: a key feature of innate immune functions of the liver
Ehlting, C., Wolf, S. D., & Bode, J. G. (2021) · Biological Chemistry · doi:10.1515/hsz-2021-0209 · Cited by 115 · see citing works
Self-citation
Cutting Edge: T Cells Respond to Lipopolysaccharide Innately via TLR4 Signaling
Zanin‐Zhorov, A., Tal, G., Cahalon, L., Cohen-Sfady, M., Pevsner‐Fischer, M., Lider, O., & Cohen, I. R. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.1.41 · Cited by 114 · see citing works
Cross-Talk Between IL-1 and IL-6 Signaling Pathways in Rheumatoid Arthritis Synovial Fibroblasts
Deon, D., Ahmed, S. T., Tai, K. W., Scaletta, N., Herrero, C., Lee, I.-H., Krause, A., & Ivashkiv, L. B. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.9.5395 · Cited by 113 · see citing works
Regulation of Suppressor of Cytokine Signaling 3 (SOCS3) mRNA Stability by TNF-α Involves Activation of the MKK6/p38MAPK/MK2 Cascade
Ehlting, C., Lai, W. S., Schaper, F., Brenndörfer, E. D., Matthes, R.-J., Heinrich, P. C., Ludwig, S., Blackshear, P. J., Gaestel, M., Häussinger, D., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.5.2813 · Cited by 112 · see citing works
Self-citation
Cholinergic agonists regulate JAK2/STAT3 signaling to suppress endothelial cell activation
Chatterjee, P. K., Al‐Abed, Y., Sherry, B. A., & Metz, C. N. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00160.2009 · Cited by 111 · see citing works
STAT1 as a novel therapeutical target in pro-atherogenic signal integration of IFNγ, TLR4 and IL-6 in vascular disease
Sikorski, K., Czerwoniec, A., Bujnicki, J. M., Wesoły, J., & Bluyssen, H. A. R. (2011) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2011.06.003 · Cited by 107 · see citing works
Stat3 Activation in Acute Lung Injury
Gao, H., Guo, R., Speyer, C. L., Reuben, J. S., Neff, T. A., Hoesel, L. M., Riedemann, N. C., McClintock, S. D., Sarma, J. V., van Rooijen, N., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.12.7703 · Cited by 106 · see citing works
Inhibition of IL-10 Receptor Function in Alveolar Macrophages by Toll-Like Receptor Agonists
Fernandez, S., Jose, P., Avdiushko, M. G., Kaplan, A. M., & Cohen, D. A. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.4.2613 · Cited by 103 · see citing works
Indirect induction of suppressor of cytokine signalling-1 in macrophages stimulated with bacterial lipopolysaccharide: partial role of autocrine/paracrine interferon-α/β
Crespo, A., Filla, M. B., Russell, S. W., & MURPHY, W. J. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3490099 · Cited by 103 · see citing works
Cross-regulation of cytokine signalling: pro-inflammatory cytokines restrict IL-6 signalling through receptor internalisation and degradation
Radtke, S., Wüller, S., Yang, X., Lippok, B. E., Mütze, B., Mais, C., de Leur, H. S.-V., Bode, J. G., Gaestel, M., Heinrich, P. C., et al. (2010) · Journal of Cell Science · doi:10.1242/jcs.065326 · Cited by 97 · see citing works
Self-citation
The expression of SOCS is altered in rheumatoid arthritis
Isomäki, P., Alanärä, T., Isohanni, P., Lagerstedt, A., Korpela, M. M., Moilanen, T. P. S., Visakorpi, T., & Silvennoinen, O. (2007) · Lara D. Veeken · doi:10.1093/rheumatology/kem198 · Cited by 97 · see citing works
Listeria monocytogenes Modulates Macrophage Cytokine Responses Through STAT Serine Phosphorylation and the Induction of Suppressor of Cytokine Signaling 3
Stoiber, D., Stockinger, S., Steinlein, P., Kovařík, J., & Decker, T. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.1.466 · Cited by 96 · see citing works
Integration of cytokine and heterologous receptor signaling pathways
Bezbradica, J. S., & Medzhitov, R. M. (2009) · Nature Immunology · doi:10.1038/ni.1713 · Cited by 96 · see citing works
Lack of gp130 expression in hepatocytes promotes liver injury1 1K.L.S. and T.W. contributed equally to this work.
StreetZ, K. L., Wüstefeld, T., Klein, C., Kallen, K.-J., Tronche, F., Betz, U. A. K., Schütz, G., Manns, M. P., Müller, W., & Trautwein, C. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00901-6 · Cited by 94 · see citing works
IL-1β and TNFα Differentially Influence NF-κB Activity and FasL-Induced Apoptosis in Primary Murine Hepatocytes During LPS-Induced Inflammation
Rex, J., Lutz, A., Faletti, L., Albrecht, U., Thomas, M., Bode, J., Borner, C., Sawodny, O., & Merfort, I. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00117 · Cited by 84 · see citing works
Self-citation
SOCS Proteins Participate in the Regulation of Innate Immune Response Caused by Viruses
Huang, S., Liu, K., Cheng, A., Wang, M., Cui, M., Huang, J., Zhu, D., Chen, S., Liu, M., Zhao, X., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.558341 · Cited by 87 · see citing works
Hematopoietic progenitor kinase 1 is a critical component of prostaglandin E2-mediated suppression of the anti-tumor immune response
Alzabin, S., Pyarajan, S., Yee, H. T., Kiefer, F., Suzuki, A., Burakoff, S. J., & Sawasdikosol, S. (2009) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-009-0761-0 · Cited by 84 · see citing works
JAK–STAT Targeting Offers Novel Therapeutic Opportunities in Sepsis
Clère-Jehl, R., Mariotte, A., Meziani, F., Bahram, S., Georgel, P., & Helms, J. (2020) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.06.007 · Cited by 84 · see citing works
The Inhibition of Interleukin-6-dependent STAT Activation by Mitogen-activated Protein Kinases Depends on Tyrosine 759 in the Cytoplasmic Tail of Glycoprotein 130
Terstegen, L., Gatsios, P., Bode, J. G., Schaper, F., Heinrich, P. C., & Graeve, L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m904148199 · Cited by 74 · see citing works
Self-citation
Mycobacterium bovis bacillus Calmette-Guérin infection promotes SOCS induction and inhibits IFN-γ-stimulated JAK/STAT signaling in J774 macrophages
Imai, K., Kurita‐Ochiai, T., & Ochiai, K. (2003) · FEMS Immunology & Medical Microbiology · doi:10.1016/s0928-8244(03)00231-1 · Cited by 73 · see citing works
Suppressor of Cytokine Signaling 2 Is a Feedback Inhibitor of TLR-Induced Activation in Human Monocyte-Derived Dendritic Cells
Posselt, G., Schwarz, H., Duschl, A., & Horejs‐Hoeck, J. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003348 · Cited by 71 · see citing works
Inflammatory transcription factors as activation markers and functional readouts in immune-to-brain communication
Rummel, C. D. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.09.003 · Cited by 70 · see citing works
Distinct Functions of the Mitogen-activated Protein Kinase-activated Protein (MAPKAP) Kinases MK2 and MK3
Ehlting, C., Ronkina, N., Böhmer, O., Albrecht, U., Bode, K. A., Lang, K. S., Kotlyarov, A., Radzioch, D., Gaestel, M., Häussinger, D., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.235275 · Cited by 70 · see citing works
Self-citation
The MKK6/p38 Mitogen-Activated Protein Kinase Pathway Is Capable of Inducing SOCS3 Gene Expression and Inhibits IL-6-Induced Transcription
Bode, J. G., Ludwig, S., Freitas, C. A. C., Schaper, F., Ruhl, M., Melmed, S. K., Heinrich, P. C., & Häussinger, D. (2001) · Biological Chemistry · doi:10.1515/bc.2001.178 · Cited by 68 · see citing works
Self-citation
Selective contribution of interleukin‐6 and leptin to brain inflammatory signals induced by systemic LPS injection in mice
Rummel, C. D., Inoue, W., Sachot, C., Poole, S., Hübschle, T., & Luheshi, G. N. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21850 · Cited by 66 · see citing works
IFNγ-dependent SOCS3 expression inhibits IL-6-induced STAT3 phosphorylation and differentially affects IL-6 mediated transcriptional responses in endothelial cells
Bluyssen, H. A. R., Rastmanesh, M. M., Tilburgs, C., Jie, K. E., Wesseling, S., Goumans, M., de Boer, P., Joles, J. A., & Braam, B. G. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00513.2009 · Cited by 66 · see citing works
Cutting Edge: IL-4 Induces Suppressor of Cytokine Signaling-3 Expression in B Cells by a Mechanism Dependent on Activation of p38 MAPK
Canfield, S. M., Lee, Y., Schröder, A., & Rothman, P. B. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.5.2494 · Cited by 66 · see citing works
SOCS3 in immune regulation of inflammatory bowel disease and inflammatory bowel disease-related cancer
Li, Y., de Haar, C. G., Peppelenbosch, M. P., & van der Woude, C. J. (2012) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2012.04.005 · Cited by 63 · see citing works
Regulation of TLR signaling and inflammation by SOCS family proteins
Yoshimura, A., Ohishi, H. M. M., Aki, D., & Hanada, T. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0403194 · Cited by 63 · see citing works
Molecular aspects of medicine: from experimental to clinical hepatology
Häussinger, D. (2004) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2004.02.001 · Cited by 62 · see citing works
Self-citation
Involvement of suppressors of cytokine signaling in toll-like receptor–mediated block of dendritic cell differentiation
Bartz, H., Avalos, N. M., Baetz, A., Heeg, K. M., & Dalpke, A. H. (2006) · Blood · doi:10.1182/blood-2006-03-008946 · Cited by 62 · see citing works
Regulation of scavenger receptor class B type I in hamster liver and Hep3B cells by endotoxin and cytokines
Khovidhunkit, W., Moser, A. H., Shigenaga, J. K., Grünfeld, C., & Feingold, K. R. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32218-5 · Cited by 62 · see citing works
Potentiation of Growth Hormone-Induced Liver Suppressors of Cytokine Signaling Messenger Ribonucleic Acid by Cytokines1
Colson, A., Cam, A. L., Maiter, D. M., Edery, M., & Thissen, J. (2000) · Endocrinology · doi:10.1210/endo.141.10.7724 · Cited by 62 · see citing works
Triggering of Toll‐like receptors modulates IFN‐γ signaling: involvement of serine 727 STAT1 phosphorylation and suppressors of cytokine signaling
Dalpke, A. H., Eckerle, S., Frey, M., & Heeg, K. M. (2003) · European Journal of Immunology · doi:10.1002/eji.200323621 · Cited by 61 · see citing works
Exhaustive exercise modifies different gene expression profiles and pathways in LPS-stimulated and un-stimulated whole blood cultures
Abbasi, A., Hauth, M., Walter, M. J., Hudemann, J., Wank, V., Niess, A. M., & Northoff, H. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.10.023 · Cited by 60 · see citing works
Interleukin-10 Anti-Inflammatory Response toBorrelia burgdorferi, the Agent of Lyme Disease: a Possible Role for Suppressors of Cytokine Signaling 1 and 3
Dennis, V. A., Jefferson, A., Singh, S. R., Ganapamo, F., & Philipp, M. T. (2006) · Infection and Immunity · doi:10.1128/iai.00678-06 · Cited by 60 · see citing works
Human immunodeficiency virus type 1 (HIV-1) Nef activates STAT3 in primary human monocyte/macrophages through the release of soluble factors: involvement of Nef domains interacting with the cell endocytotic machinery
Percario, Z. A., Olivetta, E., Fiorucci, G., Mangino, G., Peretti, S., Romeo, G., Affabris, E., & Federico, M. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0403161 · Cited by 59 · see citing works
Dendritic cell quiescence during systemic inflammation driven by LPS stimulation of radioresistant cells in vivo
Nolte, M. A., LeibundGut‐Landmann, S., Joffre, O. P., & Sousa, C. R. E. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070325 · Cited by 59 · see citing works
Suppressor of cytokine signaling 3 inhibits head kidney macrophage activation and cytokine expression in Scophthalmus maximus
Zhang, M., Xiao, Z., & Sun, L. (2010) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2010.09.006 · Cited by 57 · see citing works
In vitro Immunogenicity of Silicon-Based Micro- and Nanostructured Surfaces
Ainslie, K. M., Tao, S. L., Popat, K. C., & Desai, T. A. (2008) · ACS Nano · doi:10.1021/nn800071k · Cited by 57 · see citing works
Signal Transduction of IL-6, Leukemia-Inhibitory Factor, and Oncostatin M: Structural Receptor Requirements for Signal Attenuation
Anhuf, D., Weißenbach, M., Schmitz, J., Sobota, R. M., Hermanns, H. M., Radtke, S., Linnemann, S., Behrmann, I., Heinrich, P. C., & Schaper, F. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.5.2535 · Cited by 57 · see citing works
Self-citation
Distinct mechanisms of induction of hepatic growth hormone resistance by endogenous IL-6, TNF-α, and IL-1β
Zhao, Y., Xiao, X., Frank, S. J., Lin, H. Y., & Xia, Y. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00652.2013 · Cited by 56 · see citing works
CD14 Signaling Restrains Chronic Inflammation through Induction of p38-MAPK/SOCS-Dependent Tolerance
Sahay, B., Patsey, R. L., Eggers, C. H., Salazar, J. C., Radolf, J. D., & Sellati, T. J. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000687 · Cited by 56 · see citing works
SOCS3 promotor hypermethylation and STAT3-NF-κB interaction downregulate SOCS3 expression in human coronary artery smooth muscle cells
Dhar, K., Rakesh, K., Pankajakshan, D., & Agrawal, D. K. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00570.2012 · Cited by 55 · see citing works
Adiponectin Enhances Antibacterial Activity of Hematopoietic Cells by Suppressing Bone Marrow Inflammation
Masamoto, Y., Arai, S., Sato, T., Yoshimi, A., Kubota, N., Takamoto, I., Iwakura, Y., Yoshimura, A., Kadowaki, T., & Kurokawa, M. (2016) · Immunity · doi:10.1016/j.immuni.2016.05.010 · Cited by 53 · see citing works
Expression of REG family genes in human inflammatory bowel diseases and its regulation
Tsuchida, C., Sakuramoto‐Tsuchida, S., Taked, M., Itaya‐Hironaka, A., Yamauchi, A., Misu, M., Shobatake, R., Uchiyama, T., Makino, M., Pujol‐Autonell, I., et al. (2017) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2017.10.003 · Cited by 51 · see citing works
The Inhibitory Effect of IL-1β on IL-6-Induced α2-Macroglobulin Expression Is Due to Activation of NF-κB
Bode, J. G., Fischer, R., Häussinger, D., Graeve, L., Heinrich, P. C., & Schaper, F. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.3.1469 · Cited by 51 · see citing works
Self-citation
TNF-α Induces Tyrosine Phosphorylation and Recruitment of the Src Homology Protein-Tyrosine Phosphatase 2 to the gp130 Signal-Transducing Subunit of the IL-6 Receptor Complex
Bode, J. G., Schweigart, J., Kehrmann, J., Ehlting, C., Schaper, F., Heinrich, P. C., & Häussinger, D. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.1.257 · Cited by 49 · see citing works
Self-citation
TLR8 and NOD signaling synergistically induce the production of IL-1β and IL-23 in monocyte-derived DCs and enhance the expression of the feedback inhibitor SOCS2
Schwarz, H., Posselt, G., Wurm, P., Ulbing, M., Duschl, A., & Horejs‐Hoeck, J. (2012) · Immunobiology · doi:10.1016/j.imbio.2012.06.007 · Cited by 47 · see citing works
Podocytes Regulate Neutrophil Recruitment by Glomerular Endothelial Cells via IL-6–Mediated Crosstalk
Kuravi, S. J., McGettrick, H. M., Satchell, S. C., Saleem, M. A., Harper, L., Williams, J. M., Rainger, G. E., & Savage, C. O. S. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1300229 · Cited by 48 · see citing works
Negative cross-talk between interleukin-3 and interleukin-11 is mediated by suppressor of cytokine signalling-3 (SOCS-3)
Magrangeas, F., Boisteau, O., DENIS, S., Jacques, Y., & Minvielle, S. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3530223 · Cited by 48 · see citing works
Negative Regulation of Cytokine Signaling
Yoshimura, A. (2005) · Clinical Reviews in Allergy & Immunology · doi:10.1385/criai:28:3:205 · Cited by 47 · see citing works
Dectin-1 Stimulation Induces Suppressor of Cytokine Signaling 1, Thereby Modulating TLR Signaling and T Cell Responses
Eberle, M.-E., & Dalpke, A. H. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103068 · Cited by 47 · see citing works
Suppressor of cytokine signaling proteins as regulators of innate immune signaling
Strebovsky, J. (2011) · Frontiers in bioscience · doi:10.2741/4008 · Cited by 46 · see citing works
Platelet factor 4 induces cell apoptosis by inhibition of STAT3 via up-regulation of SOCS3 expression in multiple myeloma
Liang, P., Cheng, S. H., Cheng, C. K., Lau, K., Lin, S.-L., Chow, E. Y. D., Chan, N. P. H., Ip, R. K. L., Wong, R. S. M., & Ng, M. H. L. (2012) · Haematologica · doi:10.3324/haematol.2012.065607 · Cited by 46 · see citing works
Early Growth Response-1 Regulates Lipopolysaccharide-induced Suppressor of Cytokine Signaling-1 Transcription
Mostecki, J. W., Showalter, B. M., & Rothman, P. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408938200 · Cited by 46 · see citing works
Suppression of IL-6 production and proliferation by blocking STAT3 activation in malignant soft tissue tumor cells
Shouda, T., Hiraoka, K., Komiya, S., Hamada, T., Zenmyo, M., Iwasaki, H., Isayama, T., Fukushima, N., Nagata, K., & Yoshimura, A. (2005) · Cancer Letters · doi:10.1016/j.canlet.2005.01.042 · Cited by 44 · see citing works
Statins induce suppressor of cytokine signaling‐3 in macrophages
Huang, K., Chen, C.-W., Chen, J.-C., & Lin, W. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)01297-3 · Cited by 44 · see citing works
Sp3 is involved in the regulation of SOCS3 gene expression
Ehlting, C., Häussinger, D., & Bode, J. G. (2005) · Biochemical Journal · doi:10.1042/bj20041101 · Cited by 44 · see citing works
Self-citation
Negative regulation of cytokine signaling and inflammatory diseases
Inagaki-Ohara, K. (2003) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(03)00070-5 · Cited by 41 · see citing works
Negative regulation of cytokine signaling by CIS/SOCS family proteins and their roles in inflammatory diseases
Hanada, T., Kinjyo, I., Inagaki-Ohara, K., & Yoshimura, A. (2003) · Springer eBooks · doi:10.1007/s10254-003-0015-z · Cited by 43 · see citing works
The Chemoattractants, IL-8 and Formyl-Methionyl-Leucyl-Phenylalanine, Regulate Granulocyte Colony-Stimulating Factor Signaling by Inducing Suppressor of Cytokine Signaling-1 Expression
Stevenson, N. J., Haan, S., McClurg, A. E., McGrattan, M. J., Armstrong, M. A., Heinrich, P. C., & Johnston, J. A. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.5.3243 · Cited by 42 · see citing works
Self-citation
Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cells
Verkaik, N. S., Esveldt, R. E., van Heemst, D., Brüggenwirth, H. T., Hoeijmakers, J. H. J., Zdzienicka, M. Z., & van Gent, D. C. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(200203)32:3 · Cited by 189 · see citing works
Interleukin-6 plays a crucial role in the hepatic expression of SOCS3 during acute inflammatory processes in vivo
Yang, X., Schaper, F., Teubner, A., Lammert, F., Heinrich, P. C., Matern, S., & Siewert, E. (2005) · Journal of Hepatology · doi:10.1016/j.jhep.2005.02.048 · Cited by 41 · see citing works
Self-citation
Suppressor of Cytokine Signaling 3 Inhibits LPS-induced IL-6 Expression in Osteoblasts by Suppressing CCAAT/Enhancer-binding Protein β Activity
Yan, C., Cao, J., Wu, M., Zhang, W., Jiang, T., Yoshimura, A., & Gao, H. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.132084 · Cited by 40 · see citing works
Induction of suppressor of cytokine signaling 3 via HSF-1-HSP70-TLR4 axis attenuates neuroinflammation and ameliorates postoperative pain
Fan, Y., Cheng, Q., Liu, B., Wang, C., Liu, H., Pan, X.-X., Teng, P., Hu, L., Zhang, G., Han, Y., et al. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.10.006 · Cited by 40 · see citing works

LPS and TNFα induce SOCS3 mRNA and inhibit STAT3activation by IL-6 in macrophages
Nimmesgern, A., Bode, J. G., Schmitz, J., Schaper, F., Heinrich, P. C., & Graeve, L. (2000) · RWTH Publications (RWTH Aachen)
Self-citation
LPS and TNFá induce SOCS3 mRNA and inhibit IL-6-induced activation of STAT3 in macrophages
Nimmesgern, A., Bode, J. G., Schmitz, J., Schaper, F., Heinrich, P. C., & Graeve, L. (2000) · RWTH Publications (RWTH Aachen)
Self-citation
Involvement of Suppressor of Cytokine Signaling-3 as a Mediator of the Inhibitory Effects of IL-10 on Lipopolysaccharide-Induced Macrophage Activation
Berlato, C., Cassatella, M. A., Kinjyo, I., Gatto, L., Yoshimura, A., & Bazzoni, F. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.12.6404 · Cited by 267 · see citing works
Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3
Niemand, C., Nimmesgern, A., Haan, S., Fischer, P., Schaper, F., Rossaint, R., Heinrich, P. C., & Müller-Newen, G. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.6.3263 · Cited by 357 · see citing works
Self-citation
Divergent mechanisms utilized by SOCS3 to mediate IL-10 inhibition of TNF-a and nitric oxide production by macrophages
Qasimi, P. (2009) · cIRcle (University of British Columbia) · doi:10.14288/1.0091997

Authors: Bode, J. G., Nimmesgern, A., Schmitz, J., Schaper, F., Schmitt, M., Frisch, W., Häussinger, D., Heinrich, P. C., & Graeve, L.
Affiliations: Universitätsklinikum Aachen (DE)
RWTH Aachen University (DE)
Düsseldorf University Hospital (DE)
ORCID: Bode, Johannes G.
Schaper, Fred
Graeve, Lutz
Venue: FEBS Letters
Publisher: Wiley
Published: 1999-12-17
Volume: 463
Issue: 3
Pages: 365-370
ISSN: 0014-5793 (ISSN-L)
1873-3468
DOI: 10.1016/s0014-5793(99)01662-2
OpenAlex: W2000974116
Semantic Scholar: 7c9e34a7b209b7772b86c66230245c02502400ce
Cited by: 196
References: 31
Citations by year: 2024: 6 · 2023: 2 · 2021: 3 · 2020: 8 · 2019: 5 · 2018: 2 · 2017: 7 · 2016: 6 · 2015: 5 · 2014: 10 · 2013: 6 · 2012: 13
FWCI: 3.58
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 32 d)
Locations: FEBS Letters (publishedVersion)
PubMed (publishedVersion)
RWTH Publications (RWTH Aachen) (submittedVersion)
Topics: Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords: SOCS3, STAT3 activation, IL-6 signaling, lipopolysaccharide, TNF-α, macrophages, p38 MAPK, hepatic macrophages, hepatocytes
MeSH terms: Interleukin-6 Inhibitors, Animals, Cell Line, DNA-Binding Proteins, Gene Expression Regulation, Humans, Kupffer Cells, Lipopolysaccharides, Liver, Macrophages, Male, Tumor Cells, Cultured, Tumor Necrosis Factor-alpha, Signal Transduction, Trans-Activators, Genes, Suppressor, Rats, Wistar, Mitogen-Activated Protein Kinases, p38 Mitogen-Activated Protein Kinases, STAT3 Transcription Factor, Mice, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

LPS and TNFα induce SOCS3 mRNA and inhibit IL‐6‐induced activation of STAT3 in macrophages

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks