Kuo, Sheng-Chu

YC-1 [3-(5′-Hydroxymethyl-2′-furyl)-1-benzyl Indazole] Inhibits Neointima Formation in Balloon-Injured Rat Carotid through Suppression of Expressions and Activities of Matrix Metalloproteinases 2 and 9

Liu, Y.-N., Pan, S.-L., Peng, C.-Y., Guh, J.-H., Huang, D.-M., Chang, Y.-L., Lin, C.-H., Pai, H.-C., Kuo, S.-C., Lee, F.-Y., et al. (2006) · The Journal of Pharmacology and Experimental Therapeutics

Protease and Inhibitor MechanismsRenin-Angiotensin System Studies

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1-Benzyl-3-(5‘-hydroxymethyl-2‘-furyl)indazole (YC-1) Derivatives as Novel Inhibitors Against Sodium Nitroprusside-Induced Apoptosis

Lien, J.-C., Lee, F.-Y., Huang, L.-J., Pan, S.-L., Guh, J.-H., Teng, C.-M., & Kuo, S.-C. (2002) · Journal of Medicinal Chemistry

Heterocyclic Compound Synthesis and BioactivityChemical synthesis and pharmacological studies

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Inhibition of extracellular Ca 2+ entry by YC-1, an activator of soluble guanylyl cyclase, through a cyclic GMP-independent pathway in rat neutrophils 1 1Abbreviations: CO, carbon monoxide; CPA, cyclopiazonic acid; fMLP, formyl-methionyl-leucyl-phenylalanine; HBSS, Hanks’ balanced salt solution; IP3, inositol 1,4,5-trisphosphate; NO, nitric oxide; PKC, protein kinase C; PKG, cyclic GMP-dependent protein kinase; PLC, phospholipase C; PMA, phorbol 12-myristate 13-acetate; Rp-8-pCPT-cGMPS, 8-(4-chlorophenylthio)guanosine-3′,5′-monophosphorothioate, Rp-isomer; sGC, soluble guanylyl cyclase; and SNP, sodium nitroprusside.

Wang, J.-P., Chang, L.-C., Huang, L.-J., & Kuo, S.-C. (2001) · Biochemical Pharmacology

Phosphodiesterase function and regulationCalcium signaling and nucleotide metabolism

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