The DOI matches its OpenAlex record; 90 of the 90 references it cites were found in a registry or an index.
The Cytokine Network in Psoriasis
Abstract
After more than a century of benign neglect, the epidermal keratinocyte is finally being recognized for its potential to initiate and propagate inflammatory/immunological skin diseases. In psoriasis, the keratinocyte, on activation, actively participates in a multicellular, multimolecular network coordinated by cytokines. This new appreciation and recognition of the central importance of epidermal keratinocytes, with its distinctive immunobiological capabilities apart from surrounding non-epithelial cell types, has occurred by using molecular biological techniques and refined morphological analysis to dissect each compartment (epidermis vs dermis) into their respective cellular constituents. By reassembling gene transcriptional and protein assessments with temporal-spatial interrelationships, and known functional properties of cytokines, chemotactic peptides, growth factors, and adhesion molecules, a coherent, biologically fascinating, mosaic view of the skin can be synthesized. In this review, the ramifications of these new discoveries in psoriasis are explored. The contemporary molecular view of the psoriatic skin microenvironment is dominated by an elevated and specific transcriptional activity on the part of hyperkinetic epidermal keratinocytes. The
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Cites
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Cited by
Kabat-Zinn, J., Wheeler, E., Light, T., Skillings, A., Scharf, M. J., Cropley, T. G., Hosmer, D., & Bernhard, J. D. (1998) · Psychosomatic Medicine · doi:10.1097/00006842-199809000-00020 · Cited by 826
Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities
Nickoloff, B. J., & Nestle, F. O. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200422147 · Cited by 544
Self-citationRyman-Rasmussen, J. P., Riviere, J. E., & Monteiro-Riviere, N. A. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700508 · Cited by 357
The Immunology of Psoriasis-Current Concepts in Pathogenesis
Sieminska, I., Pieniawska, M., & Grzywa, T. M. (2024) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-024-08991-7 · Cited by 346
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Metadata
- Authors
- Nickoloff, B. J.
- Venue
- Archives of Dermatology
- Publisher
- American Medical Association
- Published
- 1991-06-01
- Volume
- 127
- Issue
- 6
- Pages
- 871-871
- ISSN
- 0003-987X (ISSN-L)
- OpenAlex
- W2065406335
- Cited by
- 344
- References
- 90
- FWCI
- 9.67
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nickoloff, B. J. (1991). The Cytokine Network in Psoriasis. Archives of Dermatology. https://doi.org/10.1001/archderm.127.6.871
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
