Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53
Abstract
Human papillomavirus type 16 (HPV-16) is a DNA tumor virus that is associated with human anogenital cancers and encodes two transforming proteins, E6 and E7. The E7 protein has been shown to bind to the retinoblastoma tumor suppressor gene product, pRB. This study shows that the E6 protein of HPV-16 is capable of binding to the cellular p53 protein. The ability of the E6 proteins from different human papillomaviruses to form complexes with p53 was assayed and found to correlate with the in vivo clinical behavior and the in vitro transforming activity of these different papillomaviruses. The wild-type p53 protein has tumor suppressor properties and has also been found in association with large T antigen and the E1B 55-kilodalton protein in cells transformed by SV40 and by adenovirus type 5, respectively, providing further evidence that the human papillomaviruses, the adenoviruses, and SV40 may effect similar cellular pathways in transformation.
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Human papillomavirus protein E6 induces interactions between TP53 and E6-associated protein (E6-AP).
“Studying the human papillomavirus protein E6, they discovered that E6 induces interactions between two host proteins: TP53, involved in viral surveillance, and one that they named E6-associated protein (E6-AP).”
From Chasing molecular glue degraders: screening approaches (2022) · cites this paper as [94]
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- Authors
- Werness, B. A., Levine, A. J., & Howley, P. M.
- Affiliations
- National Institutes of Health (US)
- Princeton University (US)
- Venue
- Science
- Published
- 1990-04-06
- Volume
- 248
- Issue
- 4951
- Pages
- 76-79
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2060786724
- Cited by
- 2,562
- References
- 48
- Citations by year
- 2026: 14 · 2025: 22 · 2024: 27 · 2023: 32 · 2022: 30 · 2021: 39 · 2020: 46 · 2019: 43 · 2018: 47 · 2017: 55 · 2016: 41 · 2015: 61 · 2014: 60 · 2013: 42 · 2012: 77
- FWCI
- 118.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
- Keywords
- HPV16, HPV 18, E6 oncoprotein, p53, protein-protein interaction, viral oncogenesis, tumor suppressor proteins, retinoblastoma protein, E7 oncoprotein, anogenital cancer, viral transformation, large T antigen, adenovirus type 5, simian virus 40
- MeSH terms
- Amino Acid Sequence, Antigens, Polyomavirus Transforming, Base Sequence, Cell Transformation, Neoplastic, Cell Transformation, Viral, Cloning, Molecular, DNA-Binding Proteins, Humans, Immunosorbent Techniques, Molecular Sequence Data, Mutation, Oncogene Proteins, Viral, Phosphoproteins, Protein Binding, Simian virus 40, Oncogene Proteins, Polymerase Chain Reaction, Tumor Suppressor Protein p53, Adenovirus Early Proteins, Papillomaviridae
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