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The Photodynamic Properties of a Particular Hematoporphyrin Derivative

LIPSON, RICHARD L.·1960·Archives of Dermatology

Abstract

In 1898 Oscar Raab, while a student in Tappeiner's laboratory, recognized that paramecia were sensitized to light by the aniline dye, acridine. This finding led to extensive studies by Tappeiner and Jodlbauer and their associates,9,19,-21and to the introduction of the term "photodynamic action," used by Tappeiner in 1904. The use of hematoporphyrin in the study of photodynamics came soon after the original studies by Raab. The first study was by Hausmann in 1908. He reported destruction of paramecia and red blood cells and described in detail the symptoms of sensitized mice on exposure to light.6-8Pfeiffer found the same thing in guinea pigs, and in 1913 Meyer-Betz sensitized himself and reported similar symptoms which lasted two months. During subsequent years, many studies1-4were carried out using hematoporphyrin hydrochloride prepared according to the classic method of Nencki and Zaleski. However, Schwartz and associates16,17have found that

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Metadata

Authors
LIPSON, R. L.
Venue
Archives of Dermatology
Published
1960-10-01
Volume
82
Issue
4
Pages
508
ISSN
0003-987X (ISSN-L)
OpenAlex
W2053155947
Cited by
365
References
0
FWCI
4.42
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: The Photodynamic Properties of a Particular Hematoporphyrin Derivative. https://app.cochat.ai/papers/10.1001/archderm.1960.01580040026005
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LIPSON, R. L. (1960). The Photodynamic Properties of a Particular Hematoporphyrin Derivative. Archives of Dermatology. https://doi.org/10.1001/archderm.1960.01580040026005

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