Cited by 72Photodynamic Therapy Research StudiesNonmelanoma Skin Cancer StudiesSkin Protection and Aging

Photodynamic therapy: A hot topic in dermato-oncology (Review)

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Tampa, Mircea, Sarbu, Maria-Isabela, Matei, Clara, Mitran, Cristina-Iulia, Mitran, Madalina-Irina, Caruntu, Constantin, Constantin, Carolina, Neagu, Monica +1 more·2019·Oncology Letters

Abstract

Photodynamic therapy (PDT) is a modern, non-invasive therapeutic method used for the destruction of various cells and tissues. It requires the simultaneous presence of three components: a photosensitizer (PS), a light source and oxygen. Precancerous skin lesions are conditions associated with a high likelihood of malignant transformation to squamous cell carcinoma. Data available so far indicate that PDT is a promising treatment method which can be successfully employed in several medical fields including dermatology, urology, ophthalmology, pneumology, cardiology, dentistry and immunology. Numerous authors therefore have studied this technique in order to improve its efficacy. As a result, significant advancement has been achieved with regard to PSs and drug delivery systems. Substantial progress was also obtained with respect to PDT for the treatment of precancerous skin lesions, several authors focusing their efforts on the study of daylight-PDT and on identifying methods of decreasing technique-related pain. This review reports on the most recent findings in PDT, with emphasis on cutaneous precancerous lesions.

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Research works printed but not linked: 4

  1. Soyer HP, Rigel DS and Wurm EMT: Actinic keratosis, basal cell carcinoma and squamous cell carcinoma. In: Dermatology. 3rd edition. Elsevier, Philadelphia, pp1773-1793, 2012.
  2. Sterry W and Stockfleth E: Malignant epithelial tumors: In: Braun-Falco's Dermatology. 3rd edition. Springer-Verlag, Berlin, Heidelberg, pp1357-1376, 2009.
  3. Denis TG and Hamblin MR: History and fundamentals of photo- dynamic therapy. In: Handbook of Photomedicine. 1st edition. CRC Press, Boca Raton, USA, pp35-42, 2014.
  4. Sterry W, Paus R, Burgdorf W and Holtermann H: Carcinoma in situ: In: Thieme Clinical Companions Dermatology. Stuttgart, New York, pp417-419, 2006.

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Authors
Tampa, M., Sarbu, M.-I., Matei, C., Mitran, C.-I., Mitran, M.-I., Caruntu, C., Constantin, C., Neagu, M., & Georgescu, S.-R.
Affiliations
  • Carol Davila University of Medicine and Pharmacy (RO)
  • Department of Dermatology, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania
  • Department of Dermatology, ‘Victor Babes’ Hospital, 030303 Bucharest, Romania
  • Department of of Physiology, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania
  • Institutul National Victor Babes (RO)
Venue
Oncology Letters
Published
2019-01-16
Volume
17
Issue
5
Pages
4085-4093
ISSN
  • 1792-1074 (ISSN-L)
  • 1792-1082
OpenAlex
W2908577291
Cited by
72
References
110
Citations by year
2026: 2 · 2024: 1 · 2023: 12 · 2022: 10 · 2021: 16 · 2020: 26 · 2019: 5
FWCI
2.40
Type
journal article
Language
en
Open access
Locations
  • Oncology Letters (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
  • Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Keywords
photodynamic therapy, photosensitizers, precancerous skin lesions, squamous cell carcinoma, daylight photodynamic therapy, drug delivery systems, treatment-related pain, non-invasive cancer treatment

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