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Some New Aspects of the Langerhans Cell
Abstract
Electron microscopic examination showed varying numbers of typical Langerhans cells in the dermis in normal human skin, pityriasis rosea, reticulum cell sarcoma, and Letterer-Siwe disease as well as among the stromal and parenchymal cells of several benign appendage tumors. Langerhans cells were observed crossing the basement membrane and an epidermal Langerhans cell in mitosis was seen. These findings suggest that Langerhans cells are not directly related to epidermal melanocytes and may constitute a self-perpetuating "intraepidermal phagocytic system" to which histiocytes from the dermis are added from time to time.
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Cited by
Valladeau, J., Ravel, O., Dezutter-Dambuyant, C., Moore, K., Kleijmeer, M., Liu, Y., Duvert-Frances, V., Vincent, C., Schmitt, D., Davoust, J., et al. (2000) · Immunity · doi:10.1016/s1074-7613(00)80160-0 · Cited by 962
Fetal monocytes and the origins of tissue-resident macrophages
Hoeffel, G., & Ginhoux, F. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.01.001 · Cited by 401
Ontogeny of Tissue-Resident Macrophages
Hoeffel, G., & Ginhoux, F. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00486 · Cited by 364
Silberberg, I., Baer, R. L., & Rosenthal, S. A. (1976) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12482139 · Cited by 296
The differentiation of the dermis in the laboratory mouse
Van Exan, R. J., & Hardy, M. H. (1984) · American Journal of Anatomy · doi:10.1002/aja.1001690204 · Cited by 24
Metadata
- Authors
- Hashimoto, K.
- Venue
- Archives of Dermatology
- Publisher
- American Medical Association (AMA)
- Published
- 1968-04-01
- Volume
- 97
- Issue
- 4
- Pages
- 450
- ISSN
- 0003-987X (ISSN-L)
- OpenAlex
- W2056195777
- Cited by
- 181
- References
- 0
- FWCI
- 21.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hashimoto, K. (1968). Some New Aspects of the Langerhans Cell. Archives of Dermatology. https://doi.org/10.1001/archderm.1968.01610100090015
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
