Ontogeny of Tissue-Resident Macrophages
Open accessAbstract
The origin of tissue-resident macrophages, crucial for homeostasis and immunity, has remained controversial until recently. Originally described as part of the mononuclear phagocyte system, macrophages were long thought to derive solely from adult blood circulating monocytes. However, accumulating evidence now shows that certain macrophage populations are in fact independent from monocyte and even from adult bone marrow hematopoiesis. These tissue-resident macrophages derive from sequential seeding of tissues by two precursors during embryonic development. Primitive macrophages generated in the yolk sac (YS) from early erythro-myeloid progenitors (EMPs), independently of the transcription factor c-Myb and bypassing monocytic intermediates, first give rise to microglia. Later, fetal monocytes, generated from c-Myb(+) EMPs that initially seed the fetal liver (FL), then give rise to the majority of other adult macrophages. Thus, hematopoietic stem cell-independent embryonic precursors transiently present in the YS and the FL give rise to long-lasting self-renewing macrophage populations.
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These markers have been identified in mouse as markers of early yolk sac myelogenesis before definitive hematopoiesis or embryonic circulation.
“which have been identified in mouse as markers of early yolk sac myelogenesis before definitive hematopoiesis or the establishment of embryonic circulation (<E8.5) 19.”
From Efficient derivation of microglia-like cells from human pluripotent stem cells (2016) · cites this paper as [19]
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Tissue-Resident Macrophage Ontogeny and Homeostasis
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Self-citationMicroglia in physiology and disease
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Monocyte differentiation and antigen-presenting functions
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Efficient derivation of microglia-like cells from human pluripotent stem cells
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Control of innate immune response by biomaterial surface topography, energy, and stiffness
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The endocytic pathway in microglia during health, aging and Alzheimer’s disease
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Microglia and Sensitive Periods in Brain Development
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Tumor-associated macrophages: Prognostic and therapeutic targets for cancer in humans and dogs
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- Authors
- Hoeffel, G., & Ginhoux, F.
- Affiliations
- Agency for Science, Technology and Research (SG)
- Corresponding author
- Hoeffel, Guillaume
- Ginhoux, Florent
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2015-09-22
- Volume
- 6
- Pages
- 486-486
- ISSN
- 1664-3224 (ISSN-L)
- PMC
- PMC4585135
- OpenAlex
- W1859780204
- Cited by
- 364
- References
- 116
- Citations by year
- 2026: 18 · 2025: 28 · 2024: 34 · 2023: 24 · 2022: 40 · 2021: 35 · 2020: 41 · 2019: 38 · 2018: 32 · 2017: 33 · 2016: 23 · 2015: 4 · 2014: 1 · 2012: 1
- FWCI
- 2.89
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Immunology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Singapore Immunology Network (SIgN) Core Grant
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Keywords
- tissue-resident macrophages, macrophage ontogeny, yolk sac macrophages, erythro-myeloid progenitors, MYB, microglia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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