Cited by 182Treatment of Major DepressionNeurotransmitter Receptor Influence on BehaviorTryptophan and brain disorders

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Brain Monoamine Oxidase A Binding in Major Depressive Disorder: Relationship to Selective Serotonin Reuptake Inhibitor Treatment, Recovery, and Recurrence

Meyer, Jeffrey H., Wilson, Alan A., Sagrati, Sandra, Miler, Laura, Rusjan, Pablo, Bloomfield, Peter M., Clark, Michael, Sacher, Julia, Voineskos, Aristotle N., Houle, Sylvain·2009·Archives of General Psychiatry

DOI 10.1001/archgenpsychiatry.2009.156

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Abstract

CONTEXT: Highly significant elevations in regional brain monoamine oxidase A (MAO-A) binding were recently reported during major depressive episodes (MDEs) of major depressive disorder (MDD). The relationship between MAO-A levels and selective serotonin reuptake inhibitor (SSRI) treatment, recovery, and recurrence in MDD is unknown. OBJECTIVES: To determine whether brain MAO-A binding changes after SSRI treatment, whether brain MAO-A binding normalizes in subjects with MDD in recovery, and whether there is a relationship between prefrontal and anterior cingulate cortex MAO-A binding in recovery and subsequent recurrence of MDE. DESIGN: Case-control study. SETTING: Tertiary care psychiatric hospital. PARTICIPANTS: Twenty-eight healthy subjects, 16 subjects with an MDE secondary to MDD, and 18 subjects with MDD in recovery underwent carbon 11-labeled harmine positron emission tomography scans. Subjects with MDE were scanned before and after 6 weeks of SSRI treatment. All were otherwise healthy, nonsmoking, and medication free. Subjects with MDD in recovery were followed up for 6 months after MAO-A binding measurement. MAIN OUTCOME MEASURE: Monoamine oxidase A V(T), an index of MAO-A density, was measured in the prefrontal cortex, anterior cingulate cortex, posterior cingulate cortex, dorsal putamen, ventral striatum, thalamus, anterior temporal cortex, midbrain, and hippocampus. RESULTS: Monoamine oxidase A V(T) was significantly elevated in each brain region both during MDE and after SSRI treatment as compared with healthy controls. During recovery, MAO-A V(T) was significantly elevated in each brain region; however, those who went on to recurrence had significantly higher MAO-A V(T) in the prefrontal and anterior cingulate cortex than those who did not. CONCLUSIONS: Elevated MAO-A binding after SSRI treatment indicates persistence of a monoamine-lowering process not present in health. This provides a strong conceptual rationale for continuing SSRI treatment during early remission. Greater MAO-A binding in the prefrontal and anterior cingulate cortex in subjects with MDD in recovery and its association with subsequent recurrence argue that deficient monoamine neuromodulation may persist into recovery and contribute to recurrence.

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Authors: Meyer, J. H., Wilson, A. A., Sagrati, S., Miler, L., Rusjan, P., Bloomfield, P. M., Clark, M., Sacher, J., Voineskos, A. N., & Houle, S.
Affiliations: Centre for Addiction and Mental Health (CA)
Corresponding author: Meyer, Jeffrey H.
ORCID: Meyer, Jeffrey H.
Rusjan, Pablo
Bloomfield, Peter M.
Sacher, Julia
Voineskos, Aristotle N.
Houle, Sylvain
Venue: Archives of General Psychiatry
Publisher: American Medical Association (AMA)
Published: 2009-12-01
Volume: 66
Issue: 12
Pages: 1304
ISSN: 0003-990X (ISSN-L)
DOI: 10.1001/archgenpsychiatry.2009.156
OpenAlex: W2152918255
Cited by: 182
References: 69
Citations by year: 2026: 4 · 2024: 5 · 2023: 6 · 2022: 11 · 2021: 10 · 2020: 12 · 2019: 9 · 2018: 12 · 2017: 14 · 2016: 10 · 2015: 21 · 2014: 12 · 2013: 17 · 2012: 24
FWCI: 9.10
Type: journal article
Language: en
Open access: closed
Locations: Archives of General Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: Bristol-Myers Squibb
Eli Lilly and Company
GlaxoSmithKline
H. Lundbeck A/S
Canadian Institutes of Health Research
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: major depressive disorder, monoamine oxidase A, selective serotonin reuptake inhibitors, depression remission, depression recurrence, prefrontal cortex, anterior cingulate cortex, monoamine depletion
MeSH terms: Adult, Brain, Brain Mapping, Carbon Radioisotopes, Major Depressive Disorder, Female, Gyrus Cinguli, Harmine, Humans, Male, Monoamine Oxidase, Recurrence, Severity of Illness Index, Tissue Distribution, Treatment Outcome, Selective Serotonin Reuptake Inhibitors, Prefrontal Cortex, Positron-Emission Tomography

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Brain Monoamine Oxidase A Binding in Major Depressive Disorder: Relationship to Selective Serotonin Reuptake Inhibitor Treatment, Recovery, and Recurrence

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