The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Neurocognitive Endophenotypes for Bipolar Disorder Identified in Multiplex Multigenerational Families
Open accessAbstract
CONTEXT: Although genetic influences on bipolar disorder are well established, localization of genes that predispose to the illness has proven difficult. Given that genes predisposing to bipolar disorder may be transmitted without expression of the categorical clinical phenotype, a strategy for identifying risk genes is to identify and map quantitative intermediate phenotypes or endophenotypes. OBJECTIVE: To adjudicate neurocognitive endophenotypes for bipolar disorder. DESIGN: All participants underwent diagnostic interviews and comprehensive neurocognitive evaluations. Neurocognitive measures found to be heritable were entered into analyses designed to determine which test results are impaired in affected individuals, are sensitive to the genetic liability for the illness, and are genetically correlated with affection status. SETTING: Central valley of Costa Rica; Mexico City, Mexico; and San Antonio, Texas. PARTICIPANTS: Seven hundred nine Latino individuals participated in the study. Of these, 660 were members of extended pedigrees with at least 2 siblings diagnosed as having bipolar disorder (n = 230). The remaining subjects were community control subjects drawn from each site who did not have a personal or family history of bipolar disorder or schizophrenia. MAIN OUTCOME MEASURE: Neurocognitive test performance. RESULTS: Two of the 22 neurocognitive variables were not significantly heritable and were excluded from subsequent analyses. Patients with bipolar disorder were impaired on 6 cognitive measures compared with nonrelated healthy controls. Nonbipolar first-degree relatives were impaired on 5 of these, and the following 3 tests were genetically correlated with affection status: Digit Symbol Coding Task, Object Delayed Response Task, and immediate facial memory. CONCLUSION: This large-scale extended pedigree study of cognitive functioning in bipolar disorder identifies measures of processing speed, working memory, and declarative (facial) memory as candidate endophenotypes for bipolar disorder.
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Cites
The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions
Gottesman, I. I., & Gould, T. D. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.4.636 · Cited by 5,615
Wellcome Trust Case Control Consortium, Ferreira, M. A. R., O'Donovan, M. C., Meng, Y. A., Jones, I. R., Ruderfer, D. M., Jones, L., Fan, J., Kirov, G., Perlis, R. H., et al. (2008) · Nature Genetics · doi:10.1038/ng.209 · Cited by 1,237
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“Although processing speed measures such as the Digit Symbol Coding Task may be negatively influenced by psychotropic medications, a recent meta-analysis in schizophrenia suggested that medication status had little effect on patient performance.(39) Furthermore, at least 2 previous studies have reported poor Digit Symb…”
Relationships among processing speed, working memory, and fluid intelligence in children
Fry, A. F., & Hale, S. (2000) · Biological Psychology · doi:10.1016/s0301-0511(00)00051-x · Cited by 606
Genes for Schizophrenia and Bipolar Disorder? Implications for Psychiatric Nosology
Craddock, N. (2005) · Schizophrenia Bulletin · doi:10.1093/schbul/sbj033 · Cited by 496
Devlin, B., Daniels, M., & Roeder, K. (1997) · Nature · doi:10.1038/41319 · Cited by 478
The endophenotype concept in psychiatric genetics
FLINT, J., & MUNAFÒ, M. R. (2007) · Psychological Medicine · doi:10.1017/s0033291706008750 · Cited by 477
Toward constructing an endophenotype strategy for bipolar disorders
Hasler, G., Drevets, W. C., Gould, T. D., Gottesman, I. I., & Manji, H. K. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.11.006 · Cited by 423
Neuropsychological performance of monozygotic twins discordant for bipolar disorder
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Future of genetics of mood disorders research
Merikangas, K. R., Chakravarti, A., Moldin, S. O., Araj, H., Blangero, J., Burmeister, M., Crabbe, J. C., Depaulo, J. R., Foulks, E., Freimer, N. B., et al. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01471-3 · Cited by 128
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Nosarti, C., Reichenberg, A., Murray, R. M., Cnattingius, S., Lambe, M. P., Yin, L., MacCabe, J., Rifkin, L., & Hultman, C. M. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.1374 · Cited by 477
Biomarkers and clinical staging in psychiatry
McGorry, P., Keshavan, M., Goldstone, S., Amminger, P., Allott, K., Berk, M., Lavoie, S., Pantelis, C., Yung, A., Wood, S., et al. (2014) · World Psychiatry · doi:10.1002/wps.20144 · Cited by 306
Cellular Circadian Clocks in Mood Disorders
McCarthy, M. J., & Welsh, D. K. (2012) · Journal of Biological Rhythms · doi:10.1177/0748730412456367 · Cited by 203
Intolerance of uncertainty as a vulnerability factor for excessive and inflexible avoidance behavior
Flores, A., López, F. J., Vervliet, B., & Cobos, P. L. (2018) · Behaviour Research and Therapy · doi:10.1016/j.brat.2018.02.008 · Cited by 155
Kulak, A., Steullet, P., Cabungcal, J.-H., Werge, T., Ingason, A., Cuenod, M., & Do, K. Q. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4858 · Cited by 124
Metadata
- Authors
- Glahn, D. C., Almasy, L., Barguil, M., Hare, E., Peralta, J. M., Kent, J. W., Dassori, A., Contreras, J., Pacheco, A., Lanzagorta, N., Nicolini, H., Raventós, H., & Escamilla, M. A.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2010-02-01
- Volume
- 67
- Issue
- 2
- Pages
- 168
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2023202278
- Cited by
- 205
- References
- 11
- FWCI
- 12.56
- Type
- journal article
- Language
- en
- Open access
- green
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- Glahn, D. C., Almasy, L., Barguil, M., Hare, E., Peralta, J. M., Kent, J. W., Dassori, A., Contreras, J., Pacheco, A., Lanzagorta, N., Nicolini, H., Raventós, H., & Escamilla, M. A. (2010). Neurocognitive Endophenotypes for Bipolar Disorder Identified in Multiplex Multigenerational Families. Archives of General Psychiatry. https://doi.org/10.1001/archgenpsychiatry.2009.184
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