Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder
Open accessAbstract
To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 x 10(-9)) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 x 10(-8), rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
An intronic SNP of CACNA1C (rs1006737) appears in multiple neuropsychiatric disorders, including ASD.
“This effort has begun for an intronic SNP of CACNA1C (rs1006737) that crops up in multiple neuropsychiatric disorders (Ferreira et al., 2008; Green et al., 2010; Moskvina et al., 2009; Nyegaard et al., 2010), including ASD (Li et al., 2015).”
From Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops (2016) · cites this paper as Ferreira et al., 2008
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
PLINK: a tool set for whole-genome association and population-based linkage analyses.
Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M. A. R., Bender, D., Maller, J., Sklar, P., de Bakker, P. I. W., Daly, M. J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/519795 · Cited by 34,089 · see citing works
Self-citationGenome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442 · see citing works
Self-citationA haplotype map of the human genome
The International HapMap Consortium (2005) · Nature · doi:10.1038/nature04226 · Cited by 5,858 · see citing works
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
Saxena, R., Voight, B. F., Lyssenko, V., Burtt, N. P., de Bakker, P. I. W., Chen, H., Roix, J. J., Kathiresan, S., Hirschhorn, J. N., Daly, M. J., et al. (2007) · Science · doi:10.1126/science.1142358 · Cited by 2,843 · see citing works
Self-citationThe Wellcome Trust Case Control Consortium, U.K.
Mossman, K. (2008) · Scientific American · doi:10.1038/scientificamerican0108-42a · Cited by 2,714 · see citing works
Rioux, J. D., Xavier, R. J., Taylor, K. D., Silverberg, M. S., Goyette, P., Huett, A., Green, T., Kuballa, P., Barmada, M. M., Datta, L. W., et al. (2007) · Nature Genetics · doi:10.1038/ng2032 · Cited by 1,769 · see citing works
Self-citationGenome-wide strategies for detecting multiple loci that influence complex diseases
Marchini, J., Donnelly, P., & Cardon, L. R. (2005) · Nature Genetics · doi:10.1038/ng1537 · Cited by 894 · see citing works
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24
Guðmundsson, J., Sulem, P., Manolescu, A. R., Amundadottir, L. T., Gudbjartsson, D. F., Helgason, A., Rafnar, Þ., Bergþorsson, J. Þ., Agnarsson, B. A., Baker, A., et al. (2007) · Nature Genetics · doi:10.1038/ng1999 · Cited by 856 · see citing works
Baum, A. E., Akula, N., Cabanero, M., Cardona, I., Corona, W., Klemens, B., Schulze, T. G., Cichon, S., Rietschel, M., Nöthen, M. M., et al. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002012 · Cited by 700 · see citing works
Whole-genome association study of bipolar disorder
Sklar, P. B., Smoller, J. W., Fan, J., Ferreira, M. A. R., Perlis, R. H., Chambert, K., Nimgaonkar, V. L., McQueen, M. B., Faraone, S. V., Kirby, A. W., et al. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002151 · Cited by 691 · see citing works
Self-citationThe local differentiation of myelinated axons at nodes of Ranvier
Poliak, S., & Peles, E. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1253 · Cited by 673 · see citing works
Kordeli, E., Lambert, S., & Bennett, V. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.5.2352 · Cited by 489 · see citing works
Two-Stage Two-Locus Models in Genome-Wide Association
Evans, D. M., Marchini, J., Morris, A. P., & Cardon, L. R. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020157 · Cited by 229 · see citing works
McQuillin, A., Rizig, M., & Gurling, H. (2007) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e328011b5b2 · Cited by 159 · see citing works
Self-citationIon Channel Functional Candidate Genes in Multigenic Neuropsychiatric Disease
Gargus, J. J. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.12.008 · Cited by 102 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Biological insights from 108 schizophrenia-associated genetic loci
Schizophrenia Working Group of the Psychiatric Genomics Consortium (2014) · Nature · doi:10.1038/nature13595 · Cited by 7,577 · see citing works
Self-citation(2013) · The Lancet · doi:10.1016/s0140-6736(12)62129-1 · Cited by 3,010 · see citing works
Genome-wide association study identifies five new schizophrenia loci
The Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium (2011) · Nature Genetics · doi:10.1038/ng.940 · Cited by 1,919 · see citing works
Self-citationGenome-wide association study identifies 30 loci associated with bipolar disorder
eQTLGen Consortium, Stahl, E. A., BIOS Consortium, the Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Breen, G., Forstner, A. J., McQuillin, A., Ripke, S., Trubetskoy, V., Mattheisen, M., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0397-8 · Cited by 1,519 · see citing works
Self-citationMullins, N., Forstner, A. J., O’Connell, K. S., Coombes, B., Coleman, J. R. I., Qiao, Z., Als, T. D., Bigdeli, T. B., Børte, S., Bryois, J., et al. (2021) · Nature Genetics · doi:10.1038/s41588-021-00857-4 · Cited by 1,517 · see citing works
Self-citationGenome-wide association analysis identifies 13 new risk loci for schizophrenia
Multicenter Genetic Studies of Schizophrenia Consortium, Ripke, S., Psychosis Endophenotypes International Consortium, Wellcome Trust Case Control Consortium 2, O'Dushlaine, C., Chambert, K., Moran, J. L., Kähler, A. K., Akterin, S., Bergen, S. E., et al. (2013) · Nature Genetics · doi:10.1038/ng.2742 · Cited by 1,496 · see citing works
Self-citationPsychiatric GWAS Consortium Bipolar Disorder Working Group, Sklar, P., Ripke, S., Scott, L. J., Andreassen, O. A., Cichon, S., Craddock, N., Edenberg, H. J., Nurnberger, J. I., Rietschel, M., et al. (2011) · Nature Genetics · doi:10.1038/ng.943 · Cited by 1,344 · see citing works
Self-citationGenomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak
Gire, S., Goba, A., Andersen, K. G., Sealfon, R. S. G., Park, D. J., Kanneh, L., Jalloh, S. C., Momoh, M., Fullah, M., Dudas, G., et al. (2014) · Science · doi:10.1126/science.1259657 · Cited by 1,218 · see citing works
Genetic architectures of psychiatric disorders: the emerging picture and its implications
Sullivan, P. F., Daly, M. J., & O'Donovan, M. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3240 · Cited by 1,177 · see citing works
Self-citationPleiotropy in complex traits: challenges and strategies
Solovieff, N., Cotsapas, C., Lee, P. H., Purcell, S. M., & Smoller, J. W. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3461 · Cited by 1,085 · see citing works
Self-citationThe Diagnosis of Mental Disorders: The Problem of Reification
Hyman, S. E. (2010) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.3.022806.091532 · Cited by 1,052 · see citing works
Li, Y., Willer, C., Sanna, S., & Abecasis, G. (2009) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.9.081307.164242 · Cited by 990 · see citing works
Common genetic variants on 5p14.1 associate with autism spectrum disorders
Wang, K., Zhang, H., Ma, D., Bucan, M., Glessner, J. T., Abrahams, B. S., Salyakina, D., Imielinski, M., Bradfield, J. P., Sleiman, P. M. A., et al. (2009) · Nature · doi:10.1038/nature07999 · Cited by 989 · see citing works
Craddock, N. J., & Sklar, P. B. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60855-7 · Cited by 635 · see citing works
Self-citationThe Kraepelinian dichotomy – going, going … but still not gone
Craddock, N., & Owen, M. J. (2010) · British Journal of Psychiatry · doi:10.1192/bjp.bp.109.073429 · Cited by 587 · see citing works
Self-citationTalkowski, M. E., Rosenfeld, J. A., Blumenthal, I., Pillalamarri, V., Chiang, C., Heilbut, A., Ernst, C., Hanscom, C., Rossin, E., Lindgren, A. M., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.028 · Cited by 577 · see citing works
Self-citationPractical aspects of imputation-driven meta-analysis of genome-wide association studies
de Bakker, P. I. W., Ferreira, M. A. R., Jia, X., Neale, B. M., Raychaudhuri, S., & Voight, B. F. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn288 · Cited by 531 · see citing works
Self-citationWellcome Trust Case Control Consortium, Green, E. K., Grozeva, D., Jones, I., Jones, L., Kirov, G., Caesar, S., Gordon-Smith, K., Fraser, C., Forty, L., et al. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.49 · Cited by 526 · see citing works
Self-citationGoldstein, B. I., Carnethon, M. R., Matthews, K. A., McIntyre, R. S., Miller, G. E., Raghuveer, G., Stoney, C. M., Wasiak, H., & McCrindle, B. W. (2015) · Circulation · doi:10.1161/cir.0000000000000229 · Cited by 519 · see citing works
Genomewide Association Studies: History, Rationale, and Prospects for Psychiatric Disorders
Psychiatric GWAS Consortium Coordinating Committee (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.08091354 · Cited by 450 · see citing works
Wray, N. R., Pergadia, M. L., Blackwood, D. H. R., Penninx, B. W. J. H., Gordon, S. D., Nyholt, D. R., Ripke, S., MacIntyre, D. J., McGhee, K. A., Maclean, A. W., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2010.109 · Cited by 444 · see citing works
Self-citationThe axon initial segment and the maintenance of neuronal polarity
Rasband, M. N. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2852 · Cited by 442 · see citing works
Genome-wide association studies in ADHD
Franke, B., Neale, B., & Faraone, S. (2009) · Human Genetics · doi:10.1007/s00439-009-0663-4 · Cited by 462 · see citing works
Andreassen, O. A., Thompson, W. K., Schork, A. J., Ripke, S., Mattingsdal, M., Kelsoe, J. R., Kendler, K. S., O’Donovan, M. C., Rujescu, D., Werge, T. M., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003455 · Cited by 402 · see citing works
Self-citationThe genetics of bipolar disorder
Barnett, J. H., & Smoller, J. W. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.03.080 · Cited by 407 · see citing works
Self-citationSullivan, P. F., de Geus, E. J. C., Willemsen, G. A. H. M., James, M. R., Smit, J. H., Zandbelt, T., Arolt, V., Baune, B., Blackwood, D., Cichon, S., et al. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.125 · Cited by 399 · see citing works
Self-citationGenome-wide Association Study of Alcohol Dependence
Treutlein, J., Cichon, S., Ridinger, M., Wodarz, N., Soyka, M., Zill, P., Maier, W., Moessner, R., Gäebel, W., Dahmen, N., et al. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.83 · Cited by 380 · see citing works
The CRF system, stress, depression and anxiety—insights from human genetic studies
Binder, E. B., & Nemeroff, C. B. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.141 · Cited by 379 · see citing works
Gene Ontology Analysis of GWA Study Data Sets Provides Insights into the Biology of Bipolar Disorder
Holmans, P., Green, E. K., Pahwa, J. S., Ferreira, M. A. R., Purcell, S. M., Sklar, P., Owen, M. J., O'Donovan, M. C., & Craddock, N. (2009) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2009.05.011 · Cited by 378 · see citing works
Self-citationTargeting voltage-gated calcium channels in neurological and psychiatric diseases
Zamponi, G. W. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2015.5 · Cited by 371 · see citing works
Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia
Ruderfer, D. M., Fanous, A. H., Ripke, S., McQuillin, A., Amdur, R. L., Schizophrenia Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Cross-Disorder Working Group of the Psychiatric Genomics Consortium, Gejman, P. V., O'Donovan, M. C., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.138 · Cited by 364 · see citing works
Self-citationMoskvina, V, Craddock, N., Holmans, P., Nikolov, I., Pahwa, J. S., Green, E., Wellcome Trust Case Control Consortium, Owen, M. J., & O'Donovan, M. C. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.133 · Cited by 363 · see citing works
Self-citationSmith, E. N., Bloss, C. S., Badner, J. A., Barrett, T., Belmonte, P. L., Berrettini, W., Byerley, W., Coryell, W., Craig, D., Edenberg, H. J., et al. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.43 · Cited by 363 · see citing works
Soria, V., Martínez‐Amorós, È., Escaramís, G., Valero, J., Pérez‐Egea, R., García, C. B., Gutiérrez‐Zotes, A., Puigdemont, D., Bayés, M., Crespo, J. M., et al. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.230 · Cited by 352 · see citing works
Genome-wide association study reveals two new risk loci for bipolar disorder
Mühleisen, T. W., Leber, M., Schulze, T. G., Strohmaier, J., Degenhardt, F., Treutlein, J., Mattheisen, M., Forstner, A. J., Schumacher, J., Breuer, R., et al. (2014) · Nature Communications · doi:10.1038/ncomms4339 · Cited by 346 · see citing works
L-type CaV1.2 calcium channels: from in vitro findings to in vivo function.
Hofmann, F., Flockerzi, V., Kahl, S., & Wegener, J. (2014) · Physiological Reviews · doi:10.1152/physrev.00016.2013 · Cited by 330 · see citing works
Genetic overlap between autism, schizophrenia and bipolar disorder
Carroll, L. S., & Owen, M. J. (2009) · Genome Medicine · doi:10.1186/gm102 · Cited by 326 · see citing works
Self-citationHigh frequencies of de novo CNVs in bipolar disorder and schizophrenia
Malhotra, D., McCarthy, S., Michaelson, J. J., Vacic, V., Burdick, K. E., Yoon, S., Cichon, S., Corvin, A., Gary, S., Gershon, E. S., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.11.007 · Cited by 325 · see citing works
“Early studies implicated a few common variants with modest effects (Baum et al., 2008; Ferreira et al., 2008).”
Self-citationThe impact of environmental factors in severe psychiatric disorders
Schmitt, A., Malchow, B., Hasan, A., & Falkai, P. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00019 · Cited by 322 · see citing works
Genetic Variation in CACNA1C Affects Brain Circuitries Related to Mental Illness
Bigos, K. L., Mattay, V. S., Callicott, J. H., Straub, R. E., Vakkalanka, R., Kolachana, B. S., Hyde, T. M., Lipska, B. K., Kleinman, J. E., & Weinberger, D. R. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.96 · Cited by 317 · see citing works
From maps to mechanisms through neuroimaging of schizophrenia
Meyer‐Lindenberg, A. (2010) · Nature · doi:10.1038/nature09569 · Cited by 314 · see citing works
Lithium in the treatment of bipolar disorder: pharmacology and pharmacogenetics
Alda, M. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.4 · Cited by 317 · see citing works
Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry
Scott, L. J., Muglia, P., Kong, X., Guan, W., Flickinger, M., Upmanyu, R., Tozzi, F., Li, J. Z., Burmeister, M., Absher, D., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813386106 · Cited by 314 · see citing works
Self-citationThe prevalence of psychosis in epilepsy; a systematic review and meta-analysis
Clancy, M., Clarke, M. C., Connor, D., Cannon, M. D., & Cotter, D. (2014) · BMC Psychiatry · doi:10.1186/1471-244x-14-75 · Cited by 314 · see citing works
Panagiotou, O. A., Ioannidis, J. P. A., & for the Genome-Wide Significance Project (2012) · International Journal of Epidemiology · doi:10.1093/ije/dyr178 · Cited by 286 · see citing works
Cichon, S., Mühleisen, T. W., Degenhardt, F. A., Mattheisen, M., Miró, X., Strohmaier, J., Steffens, M., Meesters, C., Herms, S., Weingarten, M., et al. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.01.017 · Cited by 286 · see citing works
Self-citationGenetic Relationships Between Schizophrenia, Bipolar Disorder, and Schizoaffective Disorder
Cardno, A. G., & Owen, M. J. (2014) · Schizophrenia Bulletin · doi:10.1093/schbul/sbu016 · Cited by 275 · see citing works
Self-citationWilliams, H. J., Norton, N., Dwyer, S., Moskvina, V., Nikolov, I., Carroll, L. S., Georgieva, L., Williams, N. M., Morris, D. W., Quinn, E. M., et al. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.36 · Cited by 279 · see citing works
Self-citationγCaMKII Shuttles Ca2+/CaM to the Nucleus to Trigger CREB Phosphorylation and Gene Expression
Ma, H., Groth, R. D., Cohen, S. M., Emery, J. F., Li, B., Hoedt, E., Zhang, G., Neubert, T. A., & Tsien, R. W. (2014) · Cell · doi:10.1016/j.cell.2014.09.019 · Cited by 278 · see citing works
Shyn, S. I., Shi, J., Kraft, J. B., Potash, J. B., Knowles, J. A., Weissman, M. M., Garriock, H. A., Yokoyama, J. S., McGrath, P. J., Peters, E. J., et al. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.125 · Cited by 270 · see citing works
Self-citationCACNA1C (Cav1.2) in the pathophysiology of psychiatric disease
Bhat, S., Dao, D. T., Terrillion, C. E., Arad, M., Smith, R. J., Soldatov, N. M., & Gould, T. D. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.06.001 · Cited by 271 · see citing works
Genome-wide association study of recurrent early-onset major depressive disorder
Shi, J., Potash, J. B., Knowles, J. A., Weissman, M. M., Coryell, W. H., Scheftner, W. A., Lawson, W. B., DePaulo, J. R., Gejman, P. V., Sanders, A. R., et al. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.124 · Cited by 267 · see citing works
Self-citationMuglia, P., Tozzi, F., Galwey, N. W., Francks, C., Upmanyu, R., Kong, X., Antoniades, A., Domenici, E., Perry, J., Rothen, S., et al. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.131 · Cited by 265 · see citing works
Personalized medicine in psychiatry: problems and promises
Ozomaro, U., Wahlestedt, C., & Nemeroff, C. B. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-132 · Cited by 237 · see citing works
The genetics of bipolar disorder
Gordovez, F. J. A., & McMahon, F. J. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0634-7 · Cited by 268 · see citing works
Common variants in TMPRSS6 are associated with iron status and erythrocyte volume
Benyamin, B., Ferreira, M. A. R., Willemsen, G. A. H. M., Gordon, S. D., Middelberg, R. P. S., McEvoy, B. P., Hottenga, J., Henders, A. K., Campbell, M. J., Wallace, L. M., et al. (2009) · Nature Genetics · doi:10.1038/ng.456 · Cited by 254 · see citing works
Self-citationGenetic Background Limits Generalizability of Genotype-Phenotype Relationships
Sittig, L. J., Carbonetto, P. S., Engel, K. A., Krauss, K. S., Barrios-Camacho, C. M., & Palmer, A. A. (2016) · Neuron · doi:10.1016/j.neuron.2016.08.013 · Cited by 247 · see citing works
A Role for Noncoding Variation in Schizophrenia
Roussos, P., Mitchell, A. C., Voloudakis, G., Fullard, J. F., Pothula, V. M., Tsang, J., Stahl, E. A., Georgakopoulos, A., Ruderfer, D. M., Charney, A., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.10.015 · Cited by 251 · see citing works
Self-citationTalkowski, M. E., Mullegama, S. V., Rosenfeld, J. A., van Bon, B. W. M., Shen, Y., Repnikova, E. A., Gastier-Foster, J., Thrush, D. L., Kathiresan, S., Ruderfer, D. M., et al. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.09.011 · Cited by 249 · see citing works
Self-citationCopy number variation in schizophrenia in Sweden
Szatkiewicz, J., O'Dushlaine, C., Chen, G., Chambert, K., Moran, J. L., Neale, B. M., Fromer, M., Ruderfer, D. M., Akterin, S., Bergen, S. E., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.40 · Cited by 240 · see citing works
Self-citationHamshere, M. L., Walters, J., Smith, R. L., Richards, A. L., Green, E., Grozeva, D., Jones, I. R., Forty, L., Jones, L. A., Gordon‐Smith, K., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.67 · Cited by 245 · see citing works
Self-citationGENDEP Investigators, MARS Investigators, STAR*D Investigators, Uher, R., Tansey, K. E., Henigsberg, N., Wolfgang, M. C., Mors, O. N., Hauser, J., Placentino, A., et al. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.12020237 · Cited by 241 · see citing works
Self-citationBergen, S. E., O'Dushlaine, C. T., Ripke, S., Lee, P. H., Ruderfer, D. M., Akterin, S., Moran, J. L., Chambert, K. D., Handsaker, R. E., Backlund, L., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.73 · Cited by 239 · see citing works
Self-citationA βIV-spectrin/CaMKII signaling complex is essential for membrane excitability in mice
Hund, T. J., Koval, O. M., Li, J., Wright, P. J., Qian, L., Snyder, J. S., Gudmundsson, H., Kline, C. F., Davidson, N. P., Cardona, N., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci43621 · Cited by 242 · see citing works
Goldstein, B. I., Birmaher, B. B., Carlson, G. A., DelBello, M. P., Findling, R. L., Fristad, M. A., Kowatch, R. A., Miklowitz, D. J., Nery, F. G., Algorta, G. P., et al. (2017) · Bipolar Disorders · doi:10.1111/bdi.12556 · Cited by 245 · see citing works
Genetic disruption of voltage-gated calcium channels in psychiatric and neurological disorders
Heyes, S., Pratt, W. S., Rees, E., Dahimène, S., Ferron, L., Owen, M. J., & DOLPHIN, A. C. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.09.002 · Cited by 234 · see citing works
Self-citationPhenomics: the systematic study of phenotypes on a genome-wide scale
Bilder, R. M., Sabb, F. W., Cannon, T. D., London, E. D., Jentsch, J. D., Parker, D. S., Poldrack, R. A., Evans, C. J., & Freimer, N. B. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.01.027 · Cited by 234 · see citing works
Frey, B. N., Andreazza, A. C., Houenou, J., Jamain, S., Goldstein, B. I., Frye, M. A., Leboyer, M., Berk, M., Malhi, G. S., Lopez-Jaramillo, C., et al. (2013) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867413478217 · Cited by 234 · see citing works
Identification of Pathways for Bipolar Disorder: A Meta-analysis
Nurnberger, J. I., Koller, D. L., Jung, J., Edenberg, H. J., Foroud, T., Guella, I., Vawter, M. P., & Kelsoe, J. R. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.176 · Cited by 234 · see citing works
Strong synaptic transmission impact by copy number variations in schizophrenia
Glessner, J., Reilly, M. P., Kim, C., Takahashi, N., Albano, A., Hou, C., Bradfield, J. P., Zhang, H., Abou‐Sleiman, P. M., Flory, J. H., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000274107 · Cited by 231 · see citing works
Doherty, J. L., & Owen, M. J. (2014) · Genome Medicine · doi:10.1186/gm546 · Cited by 228 · see citing works
Self-citationSchork, A. J., Won, H., Appadurai, V., Nudel, R., Gandal, M., Delaneau, O., Revsbech Christiansen, M., Hougaard, D. M., Bækved-Hansen, M., Bybjerg-Grauholm, J., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0320-0 · Cited by 223 · see citing works
Self-citationDisruption of the Axon Initial Segment Cytoskeleton Is a New Mechanism for Neuronal Injury
Schafer, D. P., Jha, S., Liu, F., Akella, T., McCullough, L. D., & Rasband, M. N. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3376-09.2009 · Cited by 222 · see citing works
Craddock, N., O'Donovan, M. C., & Owen, M. J. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp020 · Cited by 216 · see citing works
Self-citationGenetics of psychosis; insights from views across the genome
O’Donovan, M. C., Craddock, N. J., & Owen, M. J. (2009) · Human Genetics · doi:10.1007/s00439-009-0703-0 · Cited by 213 · see citing works
Self-citationGee, S., Ellwood, I., Patel, T., Luongo, F., Deisseroth, K., & Sohal, V. S. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5835-11.2012 · Cited by 214 · see citing works
Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression
Huang, J., Perlis, R. H., Lee, P. H., Rush, A. J., Fava, M., Sachs, G. S., Lieberman, J., Hamilton, S. P., Sullivan, P., Sklar, P., et al. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09091335 · Cited by 213 · see citing works
Self-citationAthanasiu, L., Mattingsdal, M., Kähler, A. K., Brown, A. A., Gústafsson, Ó., Agartz, I., Giegling, I., Muglia, P., Cichon, S., Rietschel, M., et al. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.02.002 · Cited by 210 · see citing works
Self-citationChen, D. T., Jiang, X., Akula, N., Shugart, Y. Y., Wendland, J. R., Steele, C. J. M., Kassem, L., Park, J.-H., Chatterjee, N., Jamain, S., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.157 · Cited by 208 · see citing works
Hou, L., Bergen, S. E., Akula, N., Song, J., Hultman, C. M., Landén, M., Adli, M., Alda, M., Ardau, R., Arias, B., et al. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw181 · Cited by 209 · see citing works
Glahn, D. C., Almasy, L. A., Barguil, M., Hare, E., Peralta, J. M., Kent, J. W., Dassori, A. M., Contreras, J., Pacheco, A., Lanzagorta, N., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.184 · Cited by 202 · see citing works
Manchia, M., Cullis, J., Turecki, G., Rouleau, G. A., Uher, R., & Alda, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076295 · Cited by 198 · see citing works
Grozeva, D. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.25 · Cited by 192 · see citing works
Self-citationWilliams, H. J., Craddock, N. J., Russo, G., Hamshere, M. L., Moskvina, V., Dwyer, S., Smith, R., Green, E., Grozeva, D., Holmans, P., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq471 · Cited by 189 · see citing works
Self-citationThe role of genetic variation in the causation of mental illness: an evolution-informed framework
Uher, R. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.85 · Cited by 189 · see citing works
Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder
Liu, Y., Blackwood, D., Caesar, S., de Geus, E. J. C., FARMER, A. E., Ferreira, M. A. R., Ferrier, I. N., Fraser, C., Gordon‐Smith, K., Green, E., et al. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.107 · Cited by 188 · see citing works
Self-citationTwo variants in Ankyrin 3 (ANK3) are independent genetic risk factors for bipolar disorder
Schulze, T. G., Detera‐Wadleigh, S. D., Akula, N., Gupta, A. K., Kassem, L., Steele, J., Pearl, J., Strohmaier, J., Breuer, R., Schwarz, M., et al. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.134 · Cited by 187 · see citing works
Electrophysiology and beyond: Multiple roles of Na+ channel β subunits in development and disease
Patiño, G. A., & Isom, L. L. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.06.050 · Cited by 183 · see citing works
CACNA1C (rs1006737) is associated with schizophrenia
Nyegaard, M., Demontis, D., Foldager, L., Hedemand, A., Flint, T. J., Sørensen, K. M., Andersen, P. S., Nordentoft, M., Werge, T., Pedersen, C. B., et al. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.69 · Cited by 182 · see citing works
Vitamin D and Depression: Cellular and Regulatory Mechanisms
Berridge, M. J. (2017) · Pharmacological Reviews · doi:10.1124/pr.116.013227 · Cited by 186 · see citing works
Calcium signalling and psychiatric disease: bipolar disorder and schizophrenia
Berridge, M. J. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1806-z · Cited by 181 · see citing works
Smith, K. R., Kopeikina, K. J., Fawcett‐Patel, J. M., Leaderbrand, K., Gao, R., Schürmann, B., Myczek, K., Radulović, J., Swanson, G. T., & Penzes, P. (2014) · Neuron · doi:10.1016/j.neuron.2014.10.010 · Cited by 177 · see citing works
MicroRNAs: Small molecules with big roles in neurodevelopment and diseases
Sun, E., & Shi, Y. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.08.005 · Cited by 178 · see citing works
MicroRNA dysregulation in psychiatric disease
Miller, B. H., & Wahlestedt, C. (2010) · Brain Research · doi:10.1016/j.brainres.2010.03.035 · Cited by 181 · see citing works
Association of Antihypertensive Drug Target Genes With Psychiatric Disorders
Chauquet, S., Zhu, Z., O’Donovan, M. C., Walters, J., Wray, N. R., & Shah, S. H. (2021) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2021.0005 · Cited by 176 · see citing works
Self-citationThe node of Ranvier in CNS pathology
Arancibia-Carcamo, I. L., & Attwell, D. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1305-z · Cited by 177 · see citing works
Rare variants in neuronal excitability genes influence risk for bipolar disorder
Ament, S. A., Szelinger, S., Glusman, G., Ashworth, J. R., Hou, L., Akula, N., Shekhtman, T., Badner, J. A., Brunkow, M. E., Mauldin, D. E., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1424958112 · Cited by 175 · see citing works
Brain Function in Carriers of a Genome-wide Supported Bipolar Disorder Variant
Erk, S., Meyer‐Lindenberg, A., Schnell, K., von Boberfeld, C. O., Esslinger, C., Kirsch, P., Grimm, O., Arnold, C., Haddad, L., Witt, S. H., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.94 · Cited by 175 · see citing works
Mitochondrial Oxidative Phosphorylation System (OXPHOS) Deficits in Schizophrenia
Bergman, O., & Ben‐Shachar, D. (2016) · The Canadian Journal of Psychiatry · doi:10.1177/0706743716648290 · Cited by 175 · see citing works
McCarthy, M. J., Nievergelt, C. M., Kelsoe, J. R., & Welsh, D. K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032091 · Cited by 172 · see citing works
- Authors
- Wellcome Trust Case Control Consortium, Ferreira, M. A. R., O'Donovan, M. C., Meng, Y. A., Jones, I. R., Ruderfer, D. M., Jones, L., Fan, J., Kirov, G., Perlis, R. H., Green, E. K., Smoller, J. W., Grozeva, D., Stone, J., Nikolov, I., Chambert, K., Hamshere, M. L., Nimgaonkar, V. L., Moskvina, V., Thase, M. E., Caesar, S., Sachs, G. S., Franklin, J., Gordon-Smith, K., Ardlie, K. G., Gabriel, S. B., Fraser, C., Blumenstiel, B., Defelice, M., Breen, G., Gill, M., Morris, D. W., Elkin, A., Muir, W. J., McGhee, K. A., Williamson, R., MacIntyre, D. J., MacLean, A. W., St Clair, D., Robinson, M., Van Beck, M., Pereira, A. C. P., Kandaswamy, R., McQuillin, A., Collier, D. A., Bass, N. J., Young, A. H., Lawrence, J., Nicol Ferrier, I., Anjorin, A., Farmer, A., Curtis, D., Scolnick, E. M., McGuffin, P., Daly, M. J., Corvin, A. P., Holmans, P. A., Blackwood, D. H., Gurling, H. M., Owen, M. J., Purcell, S. M., Sklar, P., & Craddock, N.
- Affiliations
- Broad Institute (US)
- Cardiff University (GB)
- University of Birmingham (GB)
- University of Pittsburgh (US)
- University of Pittsburgh Medical Center (US)
- Harvard University (US)
- King's College London (GB)
- Trinity College Dublin (IE)
- Royal Edinburgh Hospital (GB)
- University College London (GB)
- University of British Columbia (CA)
- Corresponding author
- Sklar, Pamela
- Craddock, Nick
- ORCID
- Ferreira, Manuel A R
- Meng, Yan A
- Jones, Ian R
- Ruderfer, Douglas M
- Jones, Lisa
- Fan, Jinbo
- Kirov, George
- Perlis, Roy H
- Green, Elaine K
- Smoller, Jordan W
- Grozeva, Detelina
- Hamshere, Marian L
- Nimgaonkar, Vishwajit L
- Ardlie, Kristin G
- Gabriel, Stacey B
- Fraser, Christine
- Defelice, Matthew
- Breen, Gerome
- Gill, Michael
- Morris, Derek W
- MacIntyre, Donald J
- Pereira, Ana C P
- Kandaswamy, Radhika
- McQuillin, Andrew
- Collier, David A
- Bass, Nicholas J
- Young, Allan H
- Lawrence, Jacob
- Curtis, David
- Scolnick, Edward M
- McGuffin, Peter
- Daly, Mark J
- Corvin, Aiden P
- Holmans, Peter A
- Blackwood, Douglas H
- Owen, Michael J
- Purcell, Shaun M
- Sklar, Pamela
- Craddock, Nick
- Venue
- Nature Genetics
- Published
- 2008-08-17
- Volume
- 40
- Issue
- 9
- Pages
- 1056-1058
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- PMC
- PMC2703780
- OpenAlex
- W2127442418
- Cited by
- 1,237
- References
- 15
- Citations by year
- 2026: 26 · 2025: 36 · 2024: 33 · 2023: 27 · 2022: 40 · 2021: 49 · 2020: 53 · 2019: 47 · 2018: 54 · 2017: 70 · 2016: 75 · 2015: 82 · 2014: 116 · 2013: 105 · 2012: 101
- FWCI
- 75.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- UCL Discovery (University College London) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- Wellcome Trust (077011, 082371, 076113)
- Broad Institute
- Sylvan C. Herman Foundation
- Science Foundation Ireland
- National Institutes of Health (n01mh80001-12-0-0, 6u54rr020278-06)
- Medical Research Council (G0500791, G9623693N)
- National Institute of Mental Health (MH067288, N01-MH80001, MH063445, MH062137, R01MH067288, R01MH063445, R01MH063420, N01 MH080001, MH63420, R01MH062137)
- National Center for Research Resources (U54-RR020278)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- bipolar disorder, ANK3, CACNA1C, ankyrin-G, L-type calcium channels, genetic susceptibility loci, channelopathies, rs1006737, disease risk variants
- MeSH terms
- Bipolar Disorder, Chromosomes, Human, Pair 10, Chromosomes, Human, Pair 12, Chromosomes, Human, Pair 15, Humans, Logistic Models, Ankyrins, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Calcium Channels, L-Type, Genome-Wide Association Study
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
