The DOI matches its Crossref record, with a small difference in title or year; 66 of the 66 references it cites were found in a registry or an index.
Interaction Between <emph type="ital">FKBP5</emph> and Childhood Trauma and Risk of Aggressive Behavior
Open accessAbstract
CONTEXT: Childhood trauma may predispose individuals to aggressive behavior, and both childhood trauma and aggressive behavior are associated with hypothalamic-pituitary-adrenal axis dysregulation. OBJECTIVE: To determine whether there would be an interaction between genetic variation in FKBP5 and childhood trauma in predicting aggressive behavior. DESIGN: Cross-sectional study. Four FKBP5 single-nucleotide polymorphisms used in previous studies (rs3800373, rs9296158, rs1360780, and rs9470080) were genotyped. Three diplotypes were derived from 2 major putatively functional haplotypes regulating protein expression that were previously associated with glucocorticoid receptor sensitivity. SETTING: Penitentiary District of Abruzzo-Molise in central Italy. PARTICIPANTS: A population of 583 male Italian prisoners recruited between 2005 and 2008. MAIN OUTCOME MEASURES: A comprehensive analysis of aggression and impulsivity was undertaken using the Brown-Goodwin Lifetime History of Aggression (BGHA) questionnaire, the Buss-Durkee Hostility Inventory (BDHI), and the Barratt Impulsiveness Scale (BIS). A history of childhood trauma was investigated with the Childhood Trauma Questionnaire. The interaction between the FKBP5 diplotypes and childhood trauma on measures of aggression was analyzed. Analyses were replicated with a second behavioral measure of aggression: violent behavior in jail. Individual single-nucleotide polymorphism analysis was performed. RESULTS: Childhood trauma had a significant effect on BGHA and BDHI scores but not on BIS scores. We observed a significant influence of the FKBP5 high-expression diplotype on both a lifetime history of aggressive behavior (BGHA) (P = .012) and violent behavior in jail (P = .025) but only in individuals exposed to childhood trauma, in particular to physical abuse. No main effect of the FKBP5 diplotypes was observed. CONCLUSION: These data suggest that childhood trauma and variants in the FKBP5 gene may interact to increase the risk of overt aggressive behavior.
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“Further clinical studies confirm minor alleles of FKBP5 being particularly sensitive and interact with ELS/CT to increase aggressive behavior (387), suicide attempts (388), and depression (389).”
From Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation (2019) · cites this paper as [387]
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“Sexual abuse was the least represented of the childhood traumas, which is consistent with previous reports by sex.(51,60,61) The interaction between FKBP5 and physical abuse in particular was strongly associated with both BGHA and violent behavior in jail, indicating that this type of childhood trauma in males may be…”
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“Researchers have presented results indicating support for the FKBP5 in the diathesis stress and/or differential susceptibility theorem without performing statistical tests to evaluate the form of these interactions (Bevilacqua 2012; Scheuer et al.”
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“Such effects may play a critical role in predicting physiological and behavioral adaptations to stress including modulation of the HPA axis (Binder et al., 2008; Roy et al., 2010; Tatro et al., 2010; Zou et al., 2010; Supriyanto et al., 2011; Bevilacqua et al., 2012).”
BackgroundCîmpianu, M. E., Onișan, E., Sărac, V. M., Sărac, I., Ganea, M., Gligor, O., Bâlici, Ș., Nicula, G. Z., Domșa, E. M., Cîmpianu, T., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26168053 · Cited by 4
“…childhood trauma are associated with the dysregulation of the HPA axis, other researchers analyzed the four SNPs in prisoners with aggressive behaviors and found an overexpression of the FKBP5 gene in subjects exposed to childhood trauma, particularly in those with a history of physical abuse [55].”
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“The cut-off scores of Bevilacqua et al. (2012) were used to determine the dimensions of childhood trauma (≥15 for emotional neglect, ≥10 for emotional abuse and ≥ 8 for physical neglect, physical abuse and sexual abuse).”
Metadata
- Authors
- Bevilacqua, L.
- Affiliations
- University of Molise (IT)
- Corresponding author
- Bevilacqua, Laura
- ORCID
- Bevilacqua, Laura
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2012-01-01
- Volume
- 69
- Issue
- 1
- Pages
- 62
- ISSN
- 0003-990X (ISSN-L)
- PMC
- PMC3437943
- OpenAlex
- W2159672641
- Cited by
- 137
- References
- 66
- Citations by year
- 2025: 4 · 2024: 3 · 2023: 7 · 2022: 8 · 2021: 6 · 2020: 6 · 2019: 11 · 2018: 15 · 2017: 12 · 2016: 19 · 2015: 13 · 2014: 11 · 2013: 14 · 2012: 8
- FWCI
- 6.30
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Archives of General Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi del Molise (submittedVersion)
- Funders
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism (Z01AA000301)
- National Institute on Drug Abuse (R01DA010336, R01DA10336-02)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Keywords
- FKBP5, childhood trauma, aggression, impulsivity, gene-environment interaction, hypothalamic-pituitary-adrenal axis, glucocorticoid receptor sensitivity, physical abuse, prisoners, single nucleotide polymorphisms
- MeSH terms
- Tacrolimus Binding Protein 5, Adult, Aged, Aged, 80 and over, Aggression, Cross-Sectional Studies, Humans, Impulsive Behavior, Interview, Psychological, Italy, Male, Middle Aged, Prisoners, Risk Factors, Genetic Variation, Tacrolimus Binding Proteins, Adult Survivors of Child Abuse, Young Adult
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