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Cited by 416

The DOI matches its OpenAlex record; 1 of the 1 references it cites were found in a registry or an index.

Neuropsychologic Findings in Hypoxemic Chronic Obstructive Pulmonary Disease

Igor Grant·1982·Archives of Internal Medicine

Abstract

As part of a six-center clinical trial of the effectiveness of continuous v nocturnal oxygen in the management of hypoxemic chronic obstructive pulmonary disease (COPD), we performed detailed neuropsychologic assessments of these patients prior to their beginning treatment. The 203 patients (age, 65 years; Pao2, 51 mm Hg; forced expiratory volume in 1 s, 0.74 L) performed significantly worse than controls on virtually all neuropsychologic tests. Moderate to severe test impairment suggestive of cerebral dysfunction was found in 42% of the patients, as compared with 14% of controls. Higher cognitive functions (abstracting ability, complex perceptual-motor integration) were most severely affected, although half the patients also showed decrements in motor speed, strength, and coordination. Low-order significant inverse correlations were found between neuropsychologic impairment and Pao2, resting arterial oxygen saturation and hemoglobin levels and maximum work. It is concluded that cerebral disturbance is common in hypoxemic COPD and may be related in part to decreased availability of oxygen to the brain.

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Metadata

Authors
Grant, I.
Venue
Archives of Internal Medicine
Publisher
American Medical Association
Published
1982-08-01
Volume
142
Issue
8
Pages
1470-1470
ISSN
0003-9926 (ISSN-L)
OpenAlex
W2032346263
Cited by
416
References
1
FWCI
12.15
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Neuropsychologic Findings in Hypoxemic Chronic Obstructive Pulmonary Disease. https://app.cochat.ai/papers/10.1001/archinte.142.8.1470
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Grant, I. (1982). Neuropsychologic Findings in Hypoxemic Chronic Obstructive Pulmonary Disease. Archives of Internal Medicine. https://doi.org/10.1001/archinte.142.8.1470

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.