The DOI matches its OpenAlex record; 1 of the 1 references it cites were found in a registry or an index.
Neuropsychologic Findings in Hypoxemic Chronic Obstructive Pulmonary Disease
Abstract
As part of a six-center clinical trial of the effectiveness of continuous v nocturnal oxygen in the management of hypoxemic chronic obstructive pulmonary disease (COPD), we performed detailed neuropsychologic assessments of these patients prior to their beginning treatment. The 203 patients (age, 65 years; Pao2, 51 mm Hg; forced expiratory volume in 1 s, 0.74 L) performed significantly worse than controls on virtually all neuropsychologic tests. Moderate to severe test impairment suggestive of cerebral dysfunction was found in 42% of the patients, as compared with 14% of controls. Higher cognitive functions (abstracting ability, complex perceptual-motor integration) were most severely affected, although half the patients also showed decrements in motor speed, strength, and coordination. Low-order significant inverse correlations were found between neuropsychologic impairment and Pao2, resting arterial oxygen saturation and hemoglobin levels and maximum work. It is concluded that cerebral disturbance is common in hypoxemic COPD and may be related in part to decreased availability of oxygen to the brain.
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Citations
Cites
Life quality of patients with chronic obstructive pulmonary disease
McSweeny, A. J. (1982) · Archives of Internal Medicine · doi:10.1001/archinte.1982.00340160057014 · Cited by 490
Cited by
HOPKINS, R. O., WEAVER, L. K., POPE, D., ORME, J. F., BIGLER, E. D., & LARSON-LOHR, V. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.160.1.9708059 · Cited by 668
The HNRC 500-Neuropsychology of Hiv infection at different disease stages
Heaton, R. K., Grant, I., Butters, N., White, D. A., Kirson, D., Atkinson, J. H., McCutchan, J. A., Taylor, M. J., Kelly, M. D., Ellis, R. J., et al. (1995) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617700000230 · Cited by 631
Self-citationRies, A. L., Carlin, B. W., Carrieri-Kohlman, V., Casaburi, R., Celli, B. R., Emery, C. F., Hodgkin, J. E., Mahler, D. A., Make, B., & Skolnick, J. (1997) · Chest · doi:10.1378/chest.112.5.1363 · Cited by 502
Studying the clinician: judgment research and psychological assessment
(1999) · Choice Reviews Online · doi:10.5860/choice.36-3045 · Cited by 444
Dodd, J. W., Getov, S. V., & Jones, P. W. (2010) · European Respiratory Journal · doi:10.1183/09031936.00125109 · Cited by 426
Metadata
- Authors
- Grant, I.
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association
- Published
- 1982-08-01
- Volume
- 142
- Issue
- 8
- Pages
- 1470-1470
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W2032346263
- Cited by
- 416
- References
- 1
- FWCI
- 12.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- Grant, I. (1982). Neuropsychologic Findings in Hypoxemic Chronic Obstructive Pulmonary Disease. Archives of Internal Medicine. https://doi.org/10.1001/archinte.142.8.1470
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.