Neuropsychological sequelae and impaired health status in survivors of severe acute respiratory distress syndrome
Abstract
Acute respiratory distress syndrome (ARDS) is a disease of acute respiratory failure manifested by severe hypoxemia with a high mortality rate. Previous outcome studies of ARDS have assessed survival and/or pulmonary function as the primary outcome variables. Cognitive or psychological outcomes following ARDS have not been described, despite the possibility that ARDS patients are at risk for brain injury through hypoxemia or other mechanisms. In the current study 55 consecutive ARDS survivors completed a battery of neuropsychological tests and questionnaires regarding health status, cognitive and psychological outcomes at the time of hospital discharge and 1 yr after onset of ARDS. At hospital discharge, 100% (55 of 55) of survivors exhibited cognitive and affective impairments, as well as problems with health status which affected their quality of life. At 1 yr after ARDS, 17 of 55 (30%) patients still exhibited generalized cognitive decline. Forty-three of 55 (78%) patients had all or at least one of the following: impaired memory, attention, concentration and/or decreased mental processing speed. One year after ARDS a substantial portion of ARDS survivors exhibit impaired health status and cognitive sequelae which may be due to hypoxemia, emboli, inflammation, drug toxicity, and/or other etiologies.
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After recovery from SARS or MERS, more than 15% of patients showed deficits in memory, attention, concentration, or mental processing speed at follow-up periods of 6 weeks to 39 months.
“In SARS and MERS, after recovery from the infection, impairment of memory, attention, concentration, or mental processing speed were reported in more than 15% of patients at a follow-up period ranging between 6 weeks and 39 months (Hopkins et al., 1999, Sheng et al., 2005).”
From Persistent psychopathology and neurocognitive impairment in COVID-19 survivors: effect of inflammatory biomarkers at three-month follow-up (2021) · cites this paper as Hopkins et al., 1999
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- Authors
- HOPKINS, R. O., WEAVER, L. K., POPE, D., ORME, J. F., BIGLER, E. D., & LARSON-LOHR, V.
- Affiliations
- Brigham Young University (US)
- ORCID
- BIGLER, ERIN D.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-07-01
- Volume
- 160
- Issue
- 1
- Pages
- 50-56
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2071853044
- Cited by
- 668
- References
- 31
- Citations by year
- 2026: 15 · 2025: 17 · 2024: 23 · 2023: 33 · 2022: 33 · 2021: 56 · 2020: 34 · 2019: 30 · 2018: 23 · 2017: 14 · 2016: 30 · 2015: 14 · 2014: 14 · 2013: 29 · 2012: 30
- FWCI
- 11.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Respiratory and Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL-50513)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
- Keywords
- acute respiratory distress syndrome, ARDS survivors, neuropsychological sequelae, cognitive impairment, hypoxemia, brain injury, health status, quality of life, memory impairment, processing speed, affective impairment, long-term outcomes
- MeSH terms
- Adolescent, Adult, Aged, Brain Damage, Chronic, Hypoxia, Brain, Female, Follow-Up Studies, Health Status, Humans, Male, Middle Aged, Neuropsychological Tests, Quality of Life, Respiratory Distress Syndrome, Risk Factors, Utah, Survival Rate
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