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Thromboembolism in Patients With the 'Lupus'-Type Circulating Anticoagulant
Abstract
Thirty-five patients with the lupus anticoagulant (LA) were followed up between 1975 and 1982. The most prevalent clinical manifestation occurring in these patients was thrombosis. Nineteen patients (54.3%) had a single or recurrent thrombotic episode. Fifteen patients (42.8%) had venous thrombosis, and arterial thrombosis manifested by stroke or transient ischemic attacks occurred in six patients. Bleeding occurred in only five patients, four of whom had severe thrombocytopenia, while no excessive bleeding was noted during 18 operative procedures. Various therapeutic regimens, including corticosteriods, nonsteroidal anti-inflammatory drugs, cytotoxic or immunosuppressive agents, had no effect on the presence of the LA in these patients. Anticoagulants were successful in the treatment and prevention of thrombotic episodes.
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Cited by
Antiphospholipid thrombosis: clinical course after the first thrombotic event in 70 patients
Rosove, M. H., & Brewer, P. M. C. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-117-4-303 · Cited by 700
Obstetric Complications Associated with the Lupus Anticoagulant
Branch, D. W., Scott, J. R., Kochenour, N. K., & Hershgold, E. (1985) · New England Journal of Medicine · doi:10.1056/nejm198511213132104 · Cited by 560
Harris, E. N. (1986) · Archives of Internal Medicine · doi:10.1001/archinte.1986.00360230069012 · Cited by 543
Immunology and clinical importance of antiphospholipid antibodies
McNeil, H. P., Chesterman, C. N., & Krilis, S. A. (1991) · Advances in immunology · doi:10.1016/s0065-2776(08)60777-4 · Cited by 481
Blank, M., Cohen, J., Toder, V, & Shoenfeld, Y. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.8.3069 · Cited by 455
Metadata
- Authors
- Elias, M. S.
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association
- Published
- 1984-03-01
- Volume
- 144
- Issue
- 3
- Pages
- 510-510
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W1967602919
- Cited by
- 322
- References
- 0
- FWCI
- 29.43
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
