The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Induction of anti-phospholipid syndrome in naive mice with mouse lupus monoclonal and human polyclonal anti-cardiolipin antibodies.
Open accessAbstract
The primary anti-phospholipid syndrome is characterized by recurrent venous and arterial thromboembolic phenomena, recurrent fetal loss, thrombocytopenia, and serological evidence of anti-cardiolipin (aCL) antibodies or/and the presence of lupus anticoagulant (prolonged activated partial thromboplastin time). The exact role of aCL antibodies in pathogenesis is not clear and the mechanism by which the antibodies may induce the various manifestations is unknown. In the current study we evaluated the effect of passive transfer of aCL antibodies (to the tail vein of naive mice) on fecundity, fetal loss (fetal resorption), and the weight of embryos and placentae. Two types of aCL antibodies were employed: (i) mouse monoclonal aCL antibodies derived from a BALB/c mouse in which experimental systemic lupus erythematosus was induced by a pathogenic idiotype (idiotype 16/6) of anti-DNA antibodies and (ii) polyclonal IgG and IgM aCL antibodies derived from serum of a patient with primary anti-phospholipid syndrome. After infusion of either antibody (10 micrograms per mouse) we could demonstrate lower fecundity rate, increased resorption index of embryos (equivalent to recurrent fetal loss), lower number of embryos per pregnancy, and lower mean weights of embryos and placentae in comparison to mice infused with appropriate control immunoglobulins. We conclude that the aCL antibodies may have direct effects on fecundity and on the outcome of pregnancy.
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Cites
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The "primary" antiphospholipid syndrome: major clinical and serological features.
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Primary Antiphospholipid Syndrome
(2020) · Frontiers Research Topics · doi:10.3389/978-2-88966-108-4 · Cited by 346
Thromboembolism in Patients With the 'Lupus'-Type Circulating Anticoagulant
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Self-citationLupus anticoagulant: An analysis of the clinical and laboratory features of 219 cases
Gastineau, D. A., Kazmier, F. J., Nichols, W. L., & Bowie, E. J. W. (1985) · American Journal of Hematology · doi:10.1002/ajh.2830190308 · Cited by 257
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Immunologic and Coagulation Disorders in Chlorpromazine-Treated Patients
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Anticardiolipin response in acute infections
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Cited by
The biosynthesis and functional role of cardiolipin
Schlame, M., Rua, D., & Greenberg, M. L. (2000) · Progress in Lipid Research · doi:10.1016/s0163-7827(00)00005-9 · Cited by 810
Guidelines on the investigation and management of antiphospholipid syndrome
Keeling, D., Mackie, I., Moore, G. W., Greer, I. A., Greaves, M., & British Committee for Standards in Haematology (2012) · British Journal of Haematology · doi:10.1111/j.1365-2141.2012.09037.x · Cited by 740
Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome
Girardi, G., Berman, J., Redecha, P., Spruce, L., Thurman, J. M., Kraus, D., Hollmann, T. J., Casali, P., Caroll, M. C., Wetsel, R. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318817 · Cited by 594
Heart Valve Involvement (Libman-Sacks Endocarditis) in the Antiphospholipid Syndrome
Hojnik, M., George, J., Ziporen, L., & Shoenfeld, Y. (1996) · Circulation · doi:10.1161/01.cir.93.8.1579 · Cited by 443
Self-citationAğar, Ç., van Os, G. M. A., Mörgelin, M., Sprenger, R. R., Marquart, J. A., Urbanus, R. T., Derksen, R. H. W. M., Meijers, J. C. M., & de Groot, P. G. (2010) · Blood · doi:10.1182/blood-2009-12-260976 · Cited by 263
Metadata
- Authors
- Blank, M., Cohen, J., Toder, V, & Shoenfeld, Y.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-04-15
- Volume
- 88
- Issue
- 8
- Pages
- 3069-3073
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2074332508
- Cited by
- 455
- References
- 26
- FWCI
- 21.06
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Induction of anti-phospholipid syndrome in naive mice with mouse lupus monoclonal and human polyclonal anti-cardiolipin antibodies. https://app.cochat.ai/papers/10.1073/pnas.88.8.3069
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- Blank, M., Cohen, J., Toder, V, & Shoenfeld, Y. (1991). Induction of anti-phospholipid syndrome in naive mice with mouse lupus monoclonal and human polyclonal anti-cardiolipin antibodies. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.88.8.3069
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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