The DOI matches its OpenAlex record.
Alanine aminotransferase in clinical practice. A review
Abstract
Alanine aminotransferase is an enzyme produced mainly in the liver. When serum activity is measured, it provides a marker of hepatic disease. This review explores the biochemistry and laboratory analysis of alanine aminotransferase in terms of its significance in human health and disease. Cut-off levels that define abnormality are rather arbitrary and this decreases the specificity of the test in apparently healthy patients. A small, but important, group of patients with alanine aminotransferase abnormality have underlying liver disease that may be treatable. Most can be diagnosed based on history, physical examination, and biochemical-serological profiles. Liver biopsy can complement the diagnostic process in selected circumstances. Literature pertaining to this is critically reviewed.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Hyeon, C. K., Chung, M. N., Sun, H. J., Kwang, H. H., Kyu Oh, D., & Suh, I. (2004) · BMJ · doi:10.1136/bmj.38050.593634.63 · Cited by 600
Sawka, M. N., Leon, L. R., Montain, S. J., & Sonna, L. A. (2011) · Comprehensive Physiology · doi:10.1002/cphy.c100082 · Cited by 470
Alanine Aminotransferase-Old Biomarker and New Concept: A Review
Liu, Z., Que, S., Xu, J., & Peng, T. (2014) · International Journal of Medical Sciences · doi:10.7150/ijms.8951 · Cited by 266
Metadata
- Authors
- Sherman, K. E.
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association
- Published
- 1991-02-01
- Volume
- 151
- Issue
- 2
- Pages
- 260-265
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W4230141849
- Cited by
- 173
- References
- 0
- FWCI
- 2.09
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Alanine aminotransferase in clinical practice. A review. https://app.cochat.ai/papers/10.1001/archinte.151.2.260
- The paper
- Sherman, K. E. (1991). Alanine aminotransferase in clinical practice. A review. Archives of Internal Medicine. https://doi.org/10.1001/archinte.151.2.260
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
