The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Normal serum aminotransferase concentration and risk of mortality from liver diseases: prospective cohort study
Open accessAbstract
OBJECTIVE: To examine the relation between the normal range of serum aminotransferase concentration and mortality from liver disease. DESIGN: Prospective cohort study. SETTING: Korea Medical Insurance Corporation study with eight years' follow up. PARTICIPANTS: 94,533 men and 47,522 women aged 35-59 years. MAIN OUTCOME MEASURE: Mortality from liver diseases according to death certificate. RESULTS: There was a positive association between the aminotransferase concentration, even within normal range (35-40 IU/l), and mortality from liver disease. Compared with the concentration < 20 IU/l, the adjusted relative risks for an aspartate aminotransferase concentration of 20-29 IU/l and 30-39 IU/l were 2.5 (95% confidence interval 2.0 to 3.0) and 8.0 (6.6 to 9.8) in men and 3.3 (1.7 to 6.4) and 18.2 (8.1 to 40.4) in women, respectively, The corresponding risks for alanine aminotransferase were 2.9 (2.4 to 3.5) and 9.5 (7.9 to 11.5) in men and 3.8 (1.9 to 7.7) and 6.6 (1.5 to 25.6) in women, respectively. According to receiver operating characteristic curves the best cut-off values for the prediction of liver disease in men were 31 IU/l for aspartate aminotransferase and 30 IU/l for alanine aminotransferase. CONCLUSION: People with slightly increased aminotransferase activity, but still within the normal range, should be closely observed and further investigated for liver diseases.
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Chobanian, A. V. (2003) · JAMA · doi:10.1001/jama.289.19.2560 · Cited by 25,386
Chobanian, A. V., Bakris, G. L., Black, H. R., Cushman, W. C., Green, L. A., Izzo, J. L., Jones, D. W., Materson, B. J., Oparil, S., Wright, J. T., et al. (2003) · Hypertension · doi:10.1161/01.hyp.0000107251.49515.c2 · Cited by 13,271
(2004) · PsycEXTRA Dataset · doi:10.1037/e442802008-001 · Cited by 2,875
Updated definitions of healthy ranges for serum alanine aminotransferase levels
Prati, D., Taioli, E., Zanella, A., Torre, E. D., Butelli, S., Del Vecchio, E., Vianello, L., Zanuso, F., Mozzi, F., Milani, S., et al. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-137-1-200207020-00006 · Cited by 1,445
Evaluation of Abnormal Liver-Enzyme Results in Asymptomatic Patients
Pratt, D. S., & Kaplan, M. M. (2000) · New England Journal of Medicine · doi:10.1056/nejm200004273421707 · Cited by 1,203
Easton, D. F., Peto, J., & Babiker, A. G. A. G. (1991) · Statistics in Medicine · doi:10.1002/sim.4780100703 · Cited by 433
Piton, A., Poynard, T., Imbert-Bismut, F., Khalil, L., Delattre, J., Pelissier, E., Sansonetti, N., & Opolon, P. (1998) · Hepatology · doi:10.1002/hep.510270505 · Cited by 301
Hultcrantz, R., Glaumann, H., Lindberg, G., & H:son Nilsson, L. (1986) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365528609034632 · Cited by 261
Pradat, P. (2002) · Hepatology · doi:10.1016/s0270-9139(02)00105-2 · Cited by 211
Alanine aminotransferase in clinical practice. A review
Sherman, K. E. (1991) · Archives of Internal Medicine · doi:10.1001/archinte.151.2.260 · Cited by 173
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Mudaliar, S., Henry, R. R., Sanyal, A. J., Morrow, L., Marschall, H., Kipnes, M., Adorini, L., Sciacca, C. I., Clopton, P., Castelloe, E., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.05.042 · Cited by 931
Cell Death and Cell Death Responses in Liver Disease: Mechanisms and Clinical Relevance
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Yuen, M.-F., Yuan, H.-J., Wong, D. K.-H., Yuen, J. C.-H., Wong, W.-M., Chan, A. O.-O., Wong, B. C.-Y., Lai, K.-C., & Lai, C.-L. (2005) · Gut · doi:10.1136/gut.2005.065136 · Cited by 375
Metadata
- Authors
- Hyeon, C. K., Chung, M. N., Sun, H. J., Kwang, H. H., Kyu Oh, D., & Suh, I.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2004-03-17
- Volume
- 328
- Issue
- 7446
- Pages
- 983
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- OpenAlex
- W2167596859
- Cited by
- 600
- References
- 16
- FWCI
- 10.80
- Type
- journal article
- Language
- en
- Open access
- bronze
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