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Atrial fibrillation and stroke. Three new studies, three remaining questions
Abstract
Three new studies help clarify important clinical issues regarding antithrombotic therapy for stroke prevention in patients with atrial fibrillation. The European Atrial Fibrillation Trial compared the efficacy of oral anticoagulation, aspirin, and placebo for stroke prevention in patients with atrial fibrillation with a recent stroke or transient ischemic attack. The results of the Stroke Prevention in Atrial Fibrillation II trial, which compared the efficacy of warfarin and aspirin, provide new information regarding the risk of intracranial hemorrhage in elderly patients with atrial fibrillation. Finally, an analysis of pooled data from the first five randomized trials identified clinical features that are predictive of stroke risk in individual patients with atrial fibrillation. These studies address unanswered questions regarding atrial fibrillation and stroke and have significant implications for patient management.
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Citations
Cited by
Appendage obliteration to reduce stroke in cardiac surgical patients with atrial fibrillation
Blackshear, J. L., & Odell, J. A. (1996) · The Annals of Thoracic Surgery · doi:10.1016/0003-4975(95)00887-x · Cited by 1,686
The Effect of Warfarin and Intensity of Anticoagulation on Outcome of Intracerebral Hemorrhage
Rosand, J., Eckman, M. H., Knudsen, K. A., Singer, D. E., & Greenberg, S. M. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.8.880 · Cited by 616
Identification of a Genetic Locus for Familial Atrial Fibrillation
Brugada, R., Tapscott, T., Czernuszewicz, G. Z., Marian, A. J., Iglesias, A., Mont, L., Brugada, J., Girona, J., Domingo, A., Bachinski, L. L., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199703273361302 · Cited by 555
Hobbs, F., Fitzmaurice, D., Mant, J., Murray, E., Jowett, S., Bryan, S., Raftery, J., Davies, M., & Lip, G. (2005) · Health Technology Assessment · doi:10.3310/hta9400 · Cited by 437
Warfarin-associated hemorrhage and cerebral amyloid angiopathy: A genetic and pathologic study
Rosand, J., Hylek, E. M., O’Donnell, H. C., & Greenberg, S. M. (2000) · Neurology · doi:10.1212/wnl.55.7.947 · Cited by 305
Metadata
- Authors
- Albers, G. W.
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association
- Published
- 1994-07-11
- Volume
- 154
- Issue
- 13
- Pages
- 1443-1448
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W4233753717
- Cited by
- 182
- References
- 0
- FWCI
- 14.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Atrial fibrillation and stroke. Three new studies, three remaining questions. https://app.cochat.ai/papers/10.1001/archinte.154.13.1443
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- Albers, G. W. (1994). Atrial fibrillation and stroke. Three new studies, three remaining questions. Archives of Internal Medicine. https://doi.org/10.1001/archinte.154.13.1443
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
