The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The Andro Project: Physiological and Hormonal Influences of Androstenedione Supplementation in Men 35 to 65 Years Old Participating in a High-Intensity Resistance Training Program
Abstract
Background Since the passage of The Dietary Supplement Health and Education Act in 1994, there has been a flood of new "dietary" supplements promoting anti-aging benefits such as the enhancement of growth hormone or testosterone levels. Androstenediol and androstenedione are such products. This study's purpose was to elucidate the physiological and hormonal effects of 200 mg/d of oral androstenediol and androstenedione supplementation in men aged 35 to 65 years while participating in a 12-week high-intensity resistance training program. Methods Fifty men not consuming any androgenic-enhancing substances and with normal total testosterone levels, prostate-specific antigen, hemoglobin, and hematocrit, and with no sign of cardiovascular or metabolic diseases participated. Subjects were randomly assigned to a placebo, androstenediol (diol), or androstenedione (dione) group using a double-blind study design. Main outcomes included serum sex hormone profile, body composition assessment, muscular strength, and blood lipid profiles. Results During the 12 weeks of androstenedione or androstenediol use, a significant increase in the aromatization by-products estrone and estradiol was observed in both groups (P =.03). In the dione group, total testosterone levels significantly increased 16% after 1 month of use, but by the end of 12 weeks, they returned to pretreatment levels. This return to baseline levels resulted from increases in aromatization and down-regulation in endogenous testo…
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Neither androstenedione nor androstenediol supplementation improved muscular strength or body composition, and both worsened HDL cholesterol profiles and increased cardiovascular risk.
“Neither supplementation with androstenedione or androstenediol improved muscular strength or body composition in patients taking these supplements, and both resulted in worsened HDL cholesterol profiles and increased cardiovascular risk (37).”
From Non-testosterone management of male hypogonadism: an examination of the existing literature (2020) · cites this paper as [37]
Serum testosterone levels increase with oral androstenedione or androstenediol but return to pretreatment baseline after 12 weeks of use.
“Serum testosterone levels increase but return to the pretreatment baseline after 12 weeks of use (37).”
From Non-testosterone management of male hypogonadism: an examination of the existing literature (2020) · cites this paper as [37]
Oral androstenedione and androstenediol supplementation increases serum levels of androstenedione and estradiol (E2).
“Studies have shown that oral androstenedione and androstenediol supplementation increases serum levels of androstenedione and estradiol (E2) (36,37).”
From Non-testosterone management of male hypogonadism: an examination of the existing literature (2020) · cites this paper as [37]
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Hormonal Responses and Adaptations to Resistance Exercise and Training
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Self-citationNon-testosterone management of male hypogonadism: an examination of the existing literature
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“The authors hypothesize that this return to pretreatment baseline testosterone level is due to increased aromatization of peripheral androstenedione and testosterone with conversion to estrone and E2, respect ively (37) .”
BackgroundInfluential
Metadata
- Authors
- Broeder, C. E., Quindry, J., Brittingham, K., Panton, L., Thomson, J., Appakondu, S., Breuel, K., Byrd, R., Douglas, J., Earnest, C., Mitchell, C., Olson, M., Roy, T., & Yarlagadda, C.
- Affiliations
- East Tennessee State University (US)
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 2000-11-13
- Volume
- 160
- Issue
- 20
- Pages
- 3093
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W2136308113
- Cited by
- 109
- References
- 2
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 4 · 2015: 3 · 2014: 2 · 2013: 3 · 2012: 2
- FWCI
- 7.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Digital Commons - East Tennessee State University (East Tennessee State University) (submittedVersion)
- Funders
- East Tennessee State University
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Social Sciences › Sociology and Political Science › Doping in Sports
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Pharmacological Effects and Assays
- Keywords
- androstenediol, androstenedione, dietary supplements, testosterone, aromatization, estradiol, luteinizing hormone, resistance training, muscle strength, body composition, HDL cholesterol, LDL/HDL ratio, apolipoprotein(a), apolipoprotein B, coronary heart disease risk, men, anti-aging supplements, serum lipids
- MeSH terms
- Adult, Aged, Androstenedione, Body Composition, Diet, Estradiol, Humans, Lipids, Male, Middle Aged, Testosterone, Androstenediol, Exercise, Dietary Supplements
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