Cited by 288Clostridium difficile and Clostridium perfringens researchMicroscopic ColitisInfection Control in Healthcare

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The Spectrum of Pseudomembranous Enterocolitis and Antibiotic-Associated Diarrhea

Hurley, Brian W., Nguyen, Cuong C.·2002·Archives of Internal Medicine

DOI 10.1001/archinte.162.19.2177

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Abstract

Pseudomembranous (entero)colitis is primarily caused by Clostridium difficile infection. The most common predisposing factor is prior use of antibiotics, including vancomycin and metronidazole, which themselves are therapy for C difficile colitis. Other risk factors have also been described. The presence of C difficile in the gastrointestinal tract leads to a spectrum of manifestations from the asymptomatic carrier state to fulminant colitis. Successful treatment of C difficile colitis requires prompt treatment with appropriate antibiotics, withdrawal of the suspected predisposing antibiotics, and, in rare cases, total colectomy. Preventive measures of adequate infection control and judicious use of antibiotics are necessary means in attempting to control the spread of C difficile infection. Attempts at making an effective human vaccine are currently under way.

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Authors: Hurley, B. W., & Nguyen, C. C.
Affiliations: Mayo Clinic in Arizona (US)
ORCID: Nguyen, Cuong C.
Venue: Archives of Internal Medicine
Publisher: American Medical Association (AMA)
Published: 2002-10-28
Volume: 162
Issue: 19
Pages: 2177
ISSN: 0003-9926 (ISSN-L)
DOI: 10.1001/archinte.162.19.2177
OpenAlex: W2120700667
Cited by: 288
References: 32
Citations by year: 2026: 4 · 2025: 5 · 2024: 1 · 2023: 1 · 2022: 6 · 2021: 10 · 2020: 64 · 2019: 8 · 2018: 5 · 2017: 12 · 2016: 4 · 2015: 12 · 2014: 10 · 2013: 9 · 2012: 12
FWCI: 5.08
Type: journal article
Language: en
Open access: closed
Locations: Archives of Internal Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
Health Sciences › Medicine › Gastroenterology › Microscopic Colitis
Health Sciences › Medicine › Infectious Diseases › Infection Control in Healthcare
Keywords: pseudomembranous colitis, Clostridium difficile infection, antibiotic-associated diarrhea, vancomycin, metronidazole, asymptomatic carriage, fulminant colitis, colectomy, infection control, antibiotic stewardship
MeSH terms: Anti-Bacterial Agents, Clostridium Infections, Diarrhea, Enterocolitis, Pseudomembranous, Humans, Recurrence, Clostridioides difficile

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The Spectrum of Pseudomembranous Enterocolitis and Antibiotic-Associated Diarrhea

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