The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
The Spectrum of Pseudomembranous Enterocolitis and Antibiotic-Associated Diarrhea
Abstract
Pseudomembranous (entero)colitis is primarily caused by Clostridium difficile infection. The most common predisposing factor is prior use of antibiotics, including vancomycin and metronidazole, which themselves are therapy for C difficile colitis. Other risk factors have also been described. The presence of C difficile in the gastrointestinal tract leads to a spectrum of manifestations from the asymptomatic carrier state to fulminant colitis. Successful treatment of C difficile colitis requires prompt treatment with appropriate antibiotics, withdrawal of the suspected predisposing antibiotics, and, in rare cases, total colectomy. Preventive measures of adequate infection control and judicious use of antibiotics are necessary means in attempting to control the spread of C difficile infection. Attempts at making an effective human vaccine are currently under way.
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In the citing paper
“Faecal analysis indicates incidence of C. difficile in AAD to be 20%,22 or less.23”
From Probiotics for the prevention of antibiotic-associated diarrhoea: A systematic review and meta-analysis (2021) · cites this paper as [22]
In the citing paper
“Although C. difficile is the most common infectious organism isolated, in most cases of AAD no causative agent is found.”
From Probiotics for the prevention of antibiotic-associated diarrhoea: A systematic review and meta-analysis (2021) · cites this paper as [22]
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Metadata
- Authors
- Hurley, B. W., & Nguyen, C. C.
- Affiliations
- Mayo Clinic in Arizona (US)
- ORCID
- Nguyen, Cuong C.
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 2002-10-28
- Volume
- 162
- Issue
- 19
- Pages
- 2177
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W2120700667
- Cited by
- 288
- References
- 32
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 1 · 2023: 1 · 2022: 6 · 2021: 10 · 2020: 64 · 2019: 8 · 2018: 5 · 2017: 12 · 2016: 4 · 2015: 12 · 2014: 10 · 2013: 9 · 2012: 12
- FWCI
- 5.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Health Sciences › Medicine › Gastroenterology › Microscopic Colitis
- Health Sciences › Medicine › Infectious Diseases › Infection Control in Healthcare
- Keywords
- pseudomembranous colitis, Clostridium difficile infection, antibiotic-associated diarrhea, vancomycin, metronidazole, asymptomatic carriage, fulminant colitis, colectomy, infection control, antibiotic stewardship
- MeSH terms
- Anti-Bacterial Agents, Clostridium Infections, Diarrhea, Enterocolitis, Pseudomembranous, Humans, Recurrence, Clostridioides difficile
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