Respiratory Consequences of Rhinovirus Infection
Abstract
Rhinoviruses, a genus of the family Picornaviridae, are the cause of more than 50% of respiratory tract infections. Complications of rhinovirus infections, which include otitis media, sinusitis, exacerbations of asthma, and other pulmonary diseases, can be significant in certain populations. Reverse transcriptase-polymerase chain reaction has allowed the identification of rhinoviruses and led to a greater appreciation of the role of this pathogen in upper and lower respiratory tract disease. Furthermore, antiviral agents with broad activity against rhinoviruses have recently been developed, have undergone clinical trials, but have not been approved for clinical use. By altering the clinical course of picornavirus infections, it may be possible to minimize their potential adverse consequences.
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TLR3 responds to the presence of many respiratory viruses, including rhinoviruses, RSV, and influenza viruses.
“TLR3 responds to the presence of many respiratory viruses, including rhinoviruses (107, 137), RSV (89), and influenza viruses (90).”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [89]
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The airway epithelium: soldier in the fight against respiratory viruses
Vareille, M., Kieninger, E., Edwards, M. R., & Regamey, N. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00014-10 · Cited by 655 · see citing works
- Authors
- Greenberg, S. B.
- Affiliations
- Baylor College of Medicine (US)
- Corresponding author
- Greenberg, Stephen B.
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 2003-02-10
- Volume
- 163
- Issue
- 3
- Pages
- 278
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W2130226958
- Cited by
- 112
- References
- 57
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 4 · 2023: 12 · 2022: 4 · 2021: 6 · 2020: 3 · 2019: 3 · 2018: 6 · 2017: 2 · 2016: 5 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 5
- FWCI
- 4.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Health Sciences › Health Professions › Emergency Medical Services › Pediatric health and respiratory diseases
- Keywords
- rhinovirus infection, respiratory infections, otitis media, sinusitis, asthma exacerbations, pulmonary complications, antiviral agents, picornavirus
- MeSH terms
- Acute Disease, Asthma, Common Cold, Cystic Fibrosis, Humans, Otitis Media, Picornaviridae Infections, Recurrence, Respiratory Tract Diseases, Rhinitis, Rhinovirus, Sinusitis, Pulmonary Disease, Chronic Obstructive
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