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Cited by 285Thyroid Disorders and TreatmentsThyroid and Parathyroid SurgeryHormonal and reproductive studies

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Association Between Increased Mortality and Mild Thyroid Dysfunction in Cardiac Patients

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Iervasi, Giorgio·2007·Archives of Internal Medicine
DOI 10.1001/archinte.167.14.1526
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Abstract

BACKGROUND: The effects of subclinical thyroid dysfunction on cardiac outcome are not well defined. METHODS: To assess the relationship between mild thyroid dysfunction and the incidence of death in cardiac patients, we evaluated 3121 cardiac patients. Cardiac and overall deaths were considered. Four groups were defined: euthyroidism, subclinical hypothyroidism (SCH), subclinical hyperthyroidism (SCT), and low triiodothyronine syndrome (low T3). RESULTS: After mean follow-up of 32 months, there were 65 and 140 cardiac and overall deaths (3.4% and 7.3%), respectively, in euthyroidism, 15 and 27 (7.2% and 13.0%) in SCH, 8 and 9 (8.2% and 9.2%) in SCT, and 59 and 119 (6.5% and 13.1%) in low T3. Survival rates for cardiac death were lower in SCH, SCT, and low T3 than in euthyroidism (log-rank test; chi2 = 19.46; P < .001). Survival rates for overall death were lower in SCH and low T3 than in euthyroidism (log-rank test; chi2 = 26.67; P < .001). After adjustment for several risk factors, hazard ratios (HRs) for cardiac death were higher in SCH (HR, 2.40; 95% confidence interval [CI], 1.36-4.21; P = .02), SCT (HR, 2.32; 95% CI, 1.11-4.85; P = .02), and low T(3) (HR, 1.63; 95% CI, 1.14-2.33; P = .007) than in euthyroidism; HRs for overall death were higher in SCH (HR, 2.01; 95% CI, 1.33-3.04; P < .001) and low T3 (HR, 1.57; 95% CI, 1.22-2.01; P < .001) but not in SCT. CONCLUSION: A mildly altered thyroid status is associated with an increased risk of mortality in patients with cardiac disease.

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Metadata

Authors
Iervasi, G.
Affiliations
Istituto di Fisiologia Clinica (IT)
Corresponding author
Iervasi, Giorgio
ORCID
Iervasi, Giorgio
Venue
Archives of Internal Medicine
Publisher
American Medical Association (AMA)
Published
2007-07-23
Volume
167
Issue
14
Pages
1526
ISSN
0003-9926 (ISSN-L)
DOI
10.1001/archinte.167.14.1526
OpenAlex
W2110352248
Cited by
285
References
25
Citations by year
2026: 1 · 2025: 5 · 2024: 11 · 2023: 7 · 2022: 15 · 2021: 14 · 2020: 24 · 2019: 14 · 2018: 22 · 2017: 17 · 2016: 14 · 2015: 12 · 2014: 24 · 2013: 23 · 2012: 21
FWCI
10.23
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • Archives of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • CINECA IRIS Institutional Research Information System (Sant'Anna School of Advanced Studies) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
subclinical hypothyroidism, subclinical hyperthyroidism, low triiodothyronine syndrome, thyroid dysfunction, cardiac mortality, all-cause mortality, cardiac patients, survival, euthyroidism, cardiovascular risk factors, thyroid hormones, mortality risk factors, mortality prediction model, risk stratification
MeSH terms
Coronary Disease, Female, Follow-Up Studies, Humans, Hyperthyroidism, Hypothyroidism, Male, Middle Aged, Mortality, Triiodothyronine, Survival Rate, Proportional Hazards Models

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