Lipoprotein(a) Levels and Risk of Future Coronary Heart Disease<subtitle>Large-Scale Prospective Data</subtitle>
Abstract
BACKGROUND: Large-scale prospective data are needed to determine whether associations between lipoprotein(a) (Lp[a]) and coronary heart disease (CHD) risk are independent of established risk factors, to characterize the shape of this relationship, and to quantify associations in relevant subgroups. METHODS: Levels of Lp(a) were measured in samples obtained at baseline from 2047 patients who had first-ever nonfatal myocardial infarction or who died of CHD during the study and from 3921 control participants in the Reykjavik Study (n=18 569), as well as in paired samples obtained 12 years apart from 372 participants to quantify within-person fluctuations. RESULTS: Baseline Lp(a) levels had little or no correlation with known cardiovascular risk factors, such as age, sex, total cholesterol level, and blood pressure. The Lp(a) values were highly consistent from decade to decade, with a regression dilution ratio (calculated on the log scale) of 0.92 (95% confidence interval, 0.85-0.99). The odds ratio for CHD, unaltered after adjustment for several established risk factors (age, sex, smoking status, blood pressure, total cholesterol, triglycerides level, diabetes mellitus, and body mass index), was 1.60 (95% confidence interval, 1.38-1.85) in a comparison of extreme thirds of baseline Lp(a) levels. Odds ratios were progressively higher with increasing Lp(a) levels and did not vary materially by several individual- or study-level characteristics. CONCLUSIONS: There are independent, continuous associations between Lp(a) levels and risk of future CHD in a broad range of individuals. Levels of Lp(a) are highly stable within individuals across many years and are only weakly correlated with known risk factors. Further assessment of their possible role in CHD prevention is warranted.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Studies over the past decade have confirmed and more robustly demonstrated a risk factor role of Lp(a) for cardiovascular disease.
“Recently, interest in Lp(a) has increased because studies over the past decade have confirmed and more robustly demonstrated a risk factor role of Lp(a) for cardiovascular disease (43-46).”
From Evaluation and Treatment of Hypertriglyceridemia: An Endocrine Society Clinical Practice Guideline (2012) · cites this paper as [43]
Hyper-Lp(a)-lipoproteinemia is a risk factor for ASCVD.
“[Statement]Hyper-Lp(a)-lipoproteinemia is a risk factor for ASCVD. (Evidence level: E-1a)”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [224]
Lp(a) is an independent risk factor for CAD and stroke.
“Lp(a) is an independent risk factor for CAD and stroke.”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [224]
When the size of apolipoprotein (a) [apo(a)] is small, the concentration of Lp(a) is high, and there is a high risk of CVD.
“When the size of apolipoprotein (a) [apo(a)] is small, the concentration of Lp(a) is high, and there is a high risk of CVD.”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [224]
Cites
Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139 · see citing works
Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases
DEYO, R. (1992) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(92)90133-8 · Cited by 10,452 · see citing works
Danesh, J., Wheeler, J. G., Hirschfield, G. M., Eda, S., Eiriksdottir, G., Rumley, A., Lowe, G. D. O., Pepys, M. B., & Gudnason, V. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032804 · Cited by 2,953 · see citing works
Danesh, J., Collins, R., Appleby, P. N., & Peto, R. (1998) · JAMA · doi:10.1001/jama.279.18.1477 · Cited by 2,027 · see citing works
Sarwar, N., Danesh, J., Eiriksdottir, G., Sigurdsson, G., Wareham, N., Bingham, S., Boekholdt, S. M., Khaw, K.-T., & Gudnason, V. (2007) · Circulation · doi:10.1161/circulationaha.106.637793 · Cited by 1,408 · see citing works
Effectiveness of Atypical Antipsychotic Drugs in Patients with Alzheimer's Disease
Schneider, L. S., Tariot, P. N., Dagerman, K. S., Davis, S. M., Hsiao, J. K., Ismail, M. S., Lebowitz, B. D., Lyketsos, C. G., Ryan, J. M., Stroup, T. S., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa061240 · Cited by 1,206 · see citing works
Psychotropic Drug Use and the Risk of Hip Fracture
Ray, W. A., Griffin, M. R., Schaffner, W., Baugh, D. K., & Melton, L. J. (1987) · New England Journal of Medicine · doi:10.1056/nejm198702123160702 · Cited by 1,006 · see citing works
Risk of Death in Elderly Users of Conventional vs. Atypical Antipsychotic Medications
Wang, P. S., Schneeweiss, S., Avorn, J., Fischer, M. A., Mogun, H., Solomon, D. H., & Brookhart, M. A. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa052827 · Cited by 959 · see citing works
Boerwinkle, E., Leffert, C. C., Lin, J., Lackner, C., Chiesa, G., & Hobbs, H. H. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115855 · Cited by 958 · see citing works
Sharrett, A. R., Ballantyne, C. M., Coady, S., HEISS, G. M., Sorlie, P. D., Catellier, D., & Patsch, W. (2001) · Circulation · doi:10.1161/hc3501.095214 · Cited by 942 · see citing works
Lipoprotein(a) and Coronary Heart Disease
Danesh, J., Collins, R., & Peto, R. (2000) · Circulation · doi:10.1161/01.cir.102.10.1082 · Cited by 938 · see citing works
Schneider, L. S., Dagerman, K., & Insel, P. S. (2006) · The American Journal of Geriatric Psychiatry · doi:10.1097/01.jgp.0000200589.01396.6d · Cited by 903 · see citing works
Oxidized Phospholipids, Lp(a) Lipoprotein, and Coronary Artery Disease
Tsimikas, S., Brilakis, E. S., Miller, E. R., McConnell, J. P., Lennon, R. J., Kornman, K. S., Witztum, J. L., & Berger, P. B. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043175 · Cited by 782 · see citing works
ROSNER, B. A., Willett, W. C., & Spiegelman, D. L. (1989) · Statistics in Medicine · doi:10.1002/sim.4780080905 · Cited by 644 · see citing works
Antipsychotic Drug Use and Mortality in Older Adults with Dementia
Gill, S. S., Bronskill, S. E., Normand, S.-L. T., Anderson, G. M., Sykora, K., Lam, K., Bell, C. M., Lee, P. E., Fischer, H. D., Herrmann, N., et al. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-146-11-200706050-00006 · Cited by 624 · see citing works
Rosengren, A., Wilhelmsen, L., Eriksson, E., Risberg, B., & Wedel, H. (1990) · BMJ · doi:10.1136/bmj.301.6763.1248 · Cited by 538 · see citing works
The Exclusion of the Elderly and Women From Clinical Trials in Acute Myocardial Infarction
Gurwitz, J. H. (1992) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1992.03490110055029 · Cited by 532 · see citing works
Alfthan, G., Pekkanen, J., Jauhiainen, M., Pitkäniemi, J. M., Karvonen, M., Tuomilehto, J. O., Salonen, J. T., & Ehnholm, C. (1994) · Atherosclerosis · doi:10.1016/0021-9150(94)90078-7 · Cited by 525 · see citing works
A Prospective Study of Lipoprotein(a) and the Risk of Myocardial Infarction
Ridker, P. M. (1993) · JAMA · doi:10.1001/jama.1993.03510180065035 · Cited by 512 · see citing works
Schaefer, E. J. (1994) · JAMA · doi:10.1001/jama.1994.03510370051031 · Cited by 487 · see citing works
Assmann, G., Schulte, H., & von Eckardstein, A. (1996) · The American Journal of Cardiology · doi:10.1016/s0002-9149(96)00159-2 · Cited by 445 · see citing works
Easton, D. F., Peto, J., & Babiker, A. G. (1991) · Statistics in Medicine · doi:10.1002/sim.4780100703 · Cited by 434 · see citing works
The incidence of adverse drug events in two large academic long-term care facilities
Gurwitz, J. H., Field, T. S., Judge, J. O., Rochon, P. A., Harrold, L. R., Cadoret, C. A., Lee, M. M., White, K., LaPrino, J., Erramuspe‐Mainard, J., et al. (2005) · The American Journal of Medicine · doi:10.1016/j.amjmed.2004.09.018 · Cited by 403 · see citing works
Gill, S. S., Rochon, P. A., Herrmann, N., Lee, P. E., Sykora, K., Gunraj, N., Normand, S.-L. T., Gurwitz, J. H., Marras, C., Wodchis, W. P., et al. (2005) · BMJ · doi:10.1136/bmj.38330.470486.8f · Cited by 402 · see citing works
Elevated Plasma Lipoprotein(a) and Coronary Heart Disease in Men Aged 55 Years and Younger
Bostom, A. G. (1996) · JAMA · doi:10.1001/jama.1996.03540070040028 · Cited by 397 · see citing works
Liu, B., Anderson, G., Mittmann, N., To, T. M., Axcell, T., & Shear, N. H. (1998) · The Lancet · doi:10.1016/s0140-6736(97)09528-7 · Cited by 387 · see citing works
Marcovina, S. M., Albers, J. J., Gabel, B. R., Koschinsky, M. L., & Gaur, V. P. (1995) · Clinical Chemistry · doi:10.1093/clinchem/41.2.246 · Cited by 355 · see citing works
Jauhiainen, M., Koskinen, P., Ehnholm, C., Frick, M. H., Mänttäri, M., Manninen, V., & Huttunen, J. K. (1991) · Atherosclerosis · doi:10.1016/0021-9150(91)90007-p · Cited by 354 · see citing works
Marcovina, S. M., Albers, J. J., Scanu, A. M., Kennedy, H., Giaculli, F., Berg, K., Couderc, R., Dati, F., Rifai, N., Sakurabayashi, I., et al. (2000) · Clinical Chemistry · doi:10.1093/clinchem/46.12.1956 · Cited by 315 · see citing works
Cremer, P., Nagel, D., Labrot, B., Mann, H., Muche, R., Elster, H., & Seidel, D. (1994) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1994.tb02373.x · Cited by 298 · see citing works
Role of Lipoprotein(a) and Apolipoprotein(a) Phenotype in Atherogenesis
Kronenberg, F., Kronenberg, M. F., Kiechl, S. J., Trenkwalder, E., Santer, P., Oberhollenzer, F., Egger, G., Utermann, G., & Willeit, J. (1999) · Circulation · doi:10.1161/01.cir.100.11.1154 · Cited by 292 · see citing works
Lp(a) Lipoprotein, Vascular Disease, and Mortality in the Elderly
Ariyo, A. A., Thach, C. T., & Tracy, R. P. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa001066 · Cited by 289 · see citing works
Marcovina, S. M., Koschinsky, M. L., Albers, J. J., & Skarlatos, S. (2003) · Clinical Chemistry · doi:10.1373/clinchem.2003.023689 · Cited by 288 · see citing works
ROSNER, B. A., Spiegelman, D. L., & Willett, W. C. (1992) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116453 · Cited by 262 · see citing works
Bostom, A. G., GAGNON, D. R., Cupples, L. A., Wilson, P. W. F., Jenner, J. L., Ordovás, J. M., Schaefer, E. J., & Castelli, W. P. (1994) · Circulation · doi:10.1161/01.cir.90.4.1688 · Cited by 254 · see citing works
Apolipoproteins and ischaemic heart disease: implications for screening
Wald, N., Watt, H., Bailey, A., Johnson, M., Ledue, T. B., & Haddow, J. E. (1994) · The Lancet · doi:10.1016/s0140-6736(94)90814-1 · Cited by 241 · see citing works
Berglund, L., & Ramakrishnan, R. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000144010.55563.63 · Cited by 240 · see citing works
Differences in Lp[a] concentrations and apo[a] polymorphs between black and white Americans
Marcovina, S. M., Albers, J. J., Wijsman, E. M., ZHANG, Z., Chapman, N. H., & Kennedy, H. (1996) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37461-7 · Cited by 236 · see citing works
Lipoprotein (a) as a predictor of coronary heart disease: the PRIME Study
Luc, G., Bard, J., Arveiler, D., Ferrières, J., Evans, A., Amouyel, P., Fruchart, J., & Ducimetière, P. (2002) · Atherosclerosis · doi:10.1016/s0021-9150(02)00026-6 · Cited by 227 · see citing works
Lee, P. E., Gill, S. S., Freedman, M., Bronskill, S. E., Hillmer, M. P., & Rochon, P. A. (2004) · BMJ · doi:10.1136/bmj.38125.465579.55 · Cited by 225 · see citing works
Danik, J. S., Rifai, N., Buring, J. E., & Ridker, P. M. (2006) · JAMA · doi:10.1001/jama.296.11.1363 · Cited by 215 · see citing works
Wild, S. H., Fortmann, S. P., & Marcovina, S. M. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.2.239 · Cited by 194 · see citing works
Predictive value of apolipoproteins in a prospective survey of coronary artery disease in men
Sigurðsson, G., Baldursdóttir, Á., Sigvaldason, H., Agnarsson, U., Þorgeirsson, G., & Sigfússon, N. (1992) · The American Journal of Cardiology · doi:10.1016/0002-9149(92)91215-p · Cited by 187 · see citing works
The Emerging Risk Factors Collaboration (2007) · European Journal of Epidemiology · doi:10.1007/s10654-007-9165-7 · Cited by 186 · see citing works
Variation in Nursing Home Antipsychotic Prescribing Rates
Rochon, P. A. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.7.676 · Cited by 183 · see citing works
Lipoprotein(a) as a risk factor for coronary artery disease
Marcovina, S. M., & Koschinsky, M. L. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00954-0 · Cited by 178 · see citing works
Atypical Antipsychotics and Parkinsonism
Rochon, P. A., Stukel, T. A., Sykora, K., Gill, S. S., Garfinkel, S., Anderson, G., Normand, S. T., Mamdani, M., Lee, P. E., Li, P., et al. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.16.1882 · Cited by 168 · see citing works
Cantin, B., Gagnon, F., Moorjani, S., Després, J., Lamarche, B., Lupien, P. J., & Dagenais, G. R. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00528-7 · Cited by 155 · see citing works
McKenney, J. M., Jones, P. H., Bays, H. E., Knopp, R. H., Kashyap, M. L., Ruoff, G. E., & McGovern, M. E. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.11.037 · Cited by 150 · see citing works
Antipsychotics in the Treatment of Delirium
Seitz, D. P., Gill, S. S., & van Zyl, L. T. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0102 · Cited by 150 · see citing works
Lipoprotein(a)-Cholesterol and Coronary Heart Disease in the Framingham Heart Study
SEMAN, L. J., DeLuca, C., Jenner, J. L., Cupples, L. A., McNamara, J. R., Wilson, P. W. F., Castelli, W. P., Ordovás, J. M., & Schaefer, E. J. (1999) · Clinical Chemistry · doi:10.1093/clinchem/45.7.1039 · Cited by 138 · see citing works
Atypical Antipsychotic Medications and Risk of Falls in Residents of Aged Care Facilities
Hien, L. T. T., Cumming, R. G., Cameron, I. D., Chen, J. S., Lord, S. R., MARCH, L. M., Schwarz, J., Couteur, D. G. L., & Sambrook, P. N. (2005) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.53403.x · Cited by 134 · see citing works
Nguyen, T. T., Ellefson, R. D., Hodge, D. O., Bailey, K. R., Kottke, T. E., & Abu-Lebdeh, H. S. (1997) · Circulation · doi:10.1161/01.cir.96.5.1390 · Cited by 133 · see citing works
Jónsdóttir, L. S., Sigfússon, N., Gudnason, V. G., Sigvaldason, H., & Thorgeirsson, G. (2002) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1177/174182670200900201 · Cited by 123 · see citing works
Liperoti, R., Gambassi, G., Lapane, K. L., Chiang, C., Pedone, C., Mor, V., & Bernabei, R. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n0901 · Cited by 108 · see citing works
Cremer, P., Nagel, D., Mann, H., Labrot, B., Müller-Berninger, R., Elster, H., & Seidel, D. (1997) · Atherosclerosis · doi:10.1016/s0021-9150(96)06030-3 · Cited by 108 · see citing works
Bronskill, S. E., Anderson, G., Sykora, K., Wodchis, W. P., Gill, S. S., Shulman, K. I., & Rochon, P. A. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52212.x · Cited by 95 · see citing works
Conventional or Atypical Antipsychotics and the Risk of Femur Fracture Among Elderly Patients
Liperoti, R., Onder, G., Lapane, K. L., Mor, V., Friedman, J. H., Bernabei, R., & Gambassi, G. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0616 · Cited by 92 · see citing works
The Apo(a) Gene is the Major Determinant of Variation in Plasma Lp(a) Levels in African Americans
Mooser, V., Scheer, D., Marcovina, S. M., Wang, J., Guerra, R., Cohen, J. C., & Hobbs, H. H. (1997) · The American Journal of Human Genetics · doi:10.1086/514851 · Cited by 86 · see citing works
Lee, P. E., Sykora, K., Gill, S. S., et al. (2005) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.53418.x · Cited by 85 · see citing works
Cantin, B., Després, J., Lamarche, B., Moorjani, S., Lupien, P. J., Bogaty, P. M., Bergeron, J., & Dagenais, G. R. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(01)02336-0 · Cited by 80 · see citing works
Reporting of age data in clinical trials of arthritis. Deficiencies and solutions
Rochon, P. A. (1993) · Archives of Internal Medicine · doi:10.1001/archinte.153.2.243 · Cited by 79 · see citing works
Apolipoprotein(a) isoforms and coronary heart disease in men
Klausen, I. C., Sjøl, A., HANSEN, P. S., Gerdes, L. U., Møller, L. F., Lemming, L., Schroll, M., & Færgeman, O. (1997) · Atherosclerosis · doi:10.1016/s0021-9150(97)00071-3 · Cited by 77 · see citing works
Antipsychotic use in the elderly: shifting trends and increasing costs
Rapoport, M. J., Mamdani, M., Shulman, K. I., Herrmann, N., & Rochon, P. A. (2005) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1358 · Cited by 75 · see citing works
Tate, J. R., Rifai, N., Berg, K., Couderc, R., Dati, F., Kostner, G. M., Sakurabayashi, I., & Steinmetz, A. (1998) · Clinical Chemistry · doi:10.1093/clinchem/44.8.1629 · Cited by 72 · see citing works
A prospective study of obesity, lipids, apolipoproteins and ischaemic heart disease in women
Coleman, M. P., Key, T. J. A., Wang, D. Y., Hermon, C., Fentiman, I. S., Allen, D., Jarvis, M. J., Pike, M. C., & Sanders, T. A. B. (1992) · Atherosclerosis · doi:10.1016/0021-9150(92)90276-m · Cited by 62 · see citing works
Howard, B. V., Le, N., Belcher, J. D., Flack, J. M., Jacobs, D. R., Lewis, C. E., Marcovina, S. M., & Perkins, L. L. (1994) · Annals of Epidemiology · doi:10.1016/1047-2797(94)90067-1 · Cited by 61 · see citing works
Price, J. F. (2001) · Atherosclerosis · doi:10.1016/s0021-9150(00)00719-x · Cited by 54 · see citing works
Sweetnam, P. M., Bolton, C., Downs, L. G., Durrington, P. N., Mackness, M., Elwood, P. C., & Yarnell, J. W. G. (2000) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2000.00725.x · Cited by 50 · see citing works
Lipoprotein (a) and coronary heart disease among women: beyond a cholesterol carrier?
Shai, I., Rimm, E. B., Hankinson, S. E., et al. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi222 · Cited by 50 · see citing works
Lipoprotein (a) as a predictor of myocardial infarction in middle-aged men
Seed, M., Ayres, K. L., Humphries, S. E., & Miller, G. J. (2001) · The American Journal of Medicine · doi:10.1016/s0002-9343(00)00652-5 · Cited by 49 · see citing works
Interactions between fibrinolysis, lipoproteins and leptin related to a first myocardial infarction
Thøgersen, A. M., Söderberg, S., Jansson, J., Dahlén, G. H., Boman, K., Nilsson, T., Lindahl, B., Weinehall, L., Stenlund, H. C., Lundberg, V., et al. (2004) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/01.hjr.0000116824.84388.a2 · Cited by 49 · see citing works
Marcovina, S. M., & Koschinsky, M. L. (2002) · Seminars in Vascular Medicine · doi:10.1055/s-2002-35404 · Cited by 43 · see citing works
Wang, W., Hu, D., Lee, E. T., et al. (2002) · Annals of Epidemiology · doi:10.1016/s1047-2797(01)00273-3 · Cited by 40 · see citing works
Dahlén, Weinehall, Weinehall, Stenlund, Jansson, Hallmans, Huhtasaari, & Wall (1998) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.1998.00422.x · Cited by 35 · see citing works
Rajecki, M., Pajunen, P., Jousilahti, P., et al. (2005) · Blood Coagulation & Fibrinolysis · doi:10.1097/01.mbc.0000161565.74387.5b · Cited by 27 · see citing works
Tavridou, A., Unwin, N. C., Bhopal, R. S., & Laker, M. F. (2003) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2003.01201.x · Cited by 22 · see citing works
Lipoprotein (a) as a risk factor for atherosclerotic diseases.
Dahlén, G. (1988) · PubMed · Cited by 22 · see citing works
Evans, R. G., Shpilberg, O., Shaten, B. J., Ali, S., Kamboh, M. I., & Kuller, L. H. (2001) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(00)00260-2 · Cited by 19 · see citing works
Risk factors for acute myocardial infarction in the elderly (the Dubbo study)
Simons, L. A., Simons, J., Friedlander, Y., & McCallum, J. C. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(01)02168-3 · Cited by 19 · see citing works
Determinants of lipoprotein(a) levels in a middle-aged working population
Braeckman, L., Bacquer, D. D., Rosseneu, M., & Backer, G. D. (1996) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a014796 · Cited by 16 · see citing works
Gaw, A., Brown, E. A., Docherty, G., & Ford, I. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00259-2 · Cited by 13 · see citing works
Boomsma, D. I., de Knijff, P., Kaptein, A., Labeur, C., Martin, N., Havekes, L. M., & Princen, H. M. G. (2000) · Twin Research · doi:10.1375/twin.3.3.152 · Cited by 13 · see citing works
D’Agostino (1998) · doi:10.1002/(sici)1097-0258(19981015)17:19
Flagged first, then by citations
Cited by
Sorted by citations
Lipoprotein(a) as a cardiovascular risk factor: current status
Nordestgaard, B. G., Chapman, M. J., Ray, K., Borén, J., Andreotti, F., Watts, G. F., Ginsberg, H., Amarenco, P., Catapano, A., Descamps, O. S., et al. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq386 · Cited by 1,807 · see citing works
(2009) · JAMA · doi:10.1001/jama.2009.1063 · Cited by 1,753 · see citing works
Evaluation and Treatment of Hypertriglyceridemia: An Endocrine Society Clinical Practice Guideline
Berglund, L., Brunzell, J. D., Goldberg, A. C., Goldberg, I. J., Sacks, F., Murad, M. H., & Stalenhoef, A. F. H. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-3213 · Cited by 887 · see citing works
Kinoshita, M., Yokote, K., Arai, H., Iida, M., Ishigaki, Y., Ishibashi, S., Umemoto, S., Egusa, G., Ohmura, H., Okamura, T., et al. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.gl2017 · Cited by 813 · see citing works
Reyes-Soffer, G., Ginsberg, H. N., Berglund, L., Duell, P. B., Heffron, S. P., Kamstrup, P. R., Lloyd-Jones, D. M., Marcovina, S. M., Yeang, C., Koschinsky, M. L., et al. (2022) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atv.0000000000000147 · Cited by 836 · see citing works
Burgess, S., Ference, B. A., Staley, J. R., Freitag, D. F., Mason, A. M., Nielsen, S. F., Willeit, P., Young, R., Surendran, P., Karthikeyan, S., et al. (2018) · JAMA Cardiology · doi:10.1001/jamacardio.2018.1470 · Cited by 689 · see citing works
HPS2-THRIVE Collaborative Group, Haynes, R., Jiang, L., Hopewell, J. C., Li, J., Chen, F., Parish, S., Landray, M. J., Collins, R., Armitage, J., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht055 · Cited by 676 · see citing works
Davidson, M. H., Ballantyne, C. M., Jacobson, T. A., Bittner, V. A., Braun, L. T., Brown, A. S., Brown, W. V., Cromwell, W. C., Goldberg, R. B., McKenney, J. M., et al. (2011) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2011.07.005 · Cited by 262 · see citing works
Jones, M. L., Tomaro-Duchesneau, C., Martoni, C. J., & Prakash, S. (2013) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2013.758706 · Cited by 190 · see citing works
Merki, E., Graham, M., Taleb, A., Leibundgut, G., Yang, X., Miller, E. R., Fu, W., Mullick, A. E., Lee, R., Willeit, P., et al. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.10.052 · Cited by 124 · see citing works
Atherogenic forms of dyslipidaemia in women with polycystic ovary syndrome
Berneis, K., Rizzo, M., Hersberger, M., Rini, G. B., Di Fede, G., Pepe, I., Spinas, G. A., & Carmina, E. (2009) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2008.01897.x · Cited by 94 · see citing works
Li, N., Li, Q., Tian, X.-Q., Qian, H.-Y., & Yang, Y.-J. (2014) · American Journal of Cardiovascular Drugs · doi:10.1007/s40256-014-0077-0 · Cited by 45 · see citing works
Enigmatic role of lipoprotein(a) in cardiovascular disease.
Anuurad, E., Enkhmaa, B., & Berglund, L. (2010) · Clinical and Translational Science · doi:10.1111/j.1752-8062.2010.00238.x · Cited by 14 · see citing works
- Authors
- Bennet, A.
- Affiliations
- University of Cambridge (GB)
- Corresponding author
- Bennet, Anna
- ORCID
- Bennet, Anna
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 2008-03-24
- Volume
- 168
- Issue
- 6
- Pages
- 598
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W2064043401
- Cited by
- 281
- References
- 84
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 12 · 2023: 13 · 2022: 11 · 2021: 9 · 2020: 15 · 2019: 13 · 2018: 15 · 2017: 13 · 2016: 15 · 2015: 16 · 2014: 16 · 2013: 25 · 2012: 17
- FWCI
- 25.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- JAMA Internal Medicine
- Funders
- British Heart Foundation
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- lipoprotein(a), coronary artery disease, cardiovascular risk factors, myocardial infarction, Reykjavik Study, regression dilution, within-person variability
- MeSH terms
- Aged, Coronary Disease, Female, Humans, Male, Middle Aged, Prospective Studies, Risk Factors, Time Factors, Lipoprotein(a)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
