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Cited by 371Pancreatic function and diabetesDiabetes Treatment and ManagementNeuropeptides and Animal Physiology

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

Entero-Insular Axis

Unger, Roger H.·1969·Archives of Internal Medicine
DOI 10.1001/archinte.1969.00300130043007
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Abstract

Evidence for an entero-insular axis is based upon studies showing that amino acids as well as glucose cause a greater and earlier release of islet cell hormones when administered via the gastrointestinal tract than occurs with comparable elevations in the plasma concentrations of the nutrients given intravenously. The ability of several gastrointestinal hormones to elicit immediate augmentation of insulin and glucagon secretion has been established. Gastrin, secretin, and pancreozymin in dogs all produce an immediate rise of insulin to a peak one minute after injection, but the response to gastrin is quantitatively trivial, while that to secretin is modest. However, pancreozymin elicits substantial release of both insulin and glucagon, and augments the insulinogenic and glucagonogenic effects of amino acids. The physiologic implications of such studies are considered.

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Crossref · 10.1001/archinte.1969.00300130043007

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Metadata

Authors
Unger, R. H.
Corresponding author
Unger, Roger H.
Venue
Archives of Internal Medicine
Publisher
American Medical Association (AMA)
Published
1969-03-01
Volume
123
Issue
3
Pages
261
ISSN
0003-9926 (ISSN-L)
DOI
10.1001/archinte.1969.00300130043007
OpenAlex
W2097717126
Cited by
371
References
20
Citations by year
2025: 4 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 6 · 2017: 7 · 2016: 7 · 2015: 6 · 2014: 4 · 2013: 5 · 2012: 6
FWCI
30.57
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
enteroinsular axis, gut-brain axis, gastrointestinal hormones, insulin secretion, glucagon secretion, amino acids, glucose, gastrin, secretin, cholecystokinin, enteroendocrine cells
MeSH terms
Insulin Secretion, Amino Acids, Animals, Blood Glucose, Cholecystokinin, Dogs, Gastrins, Gastrointestinal Hormones, Glucagon, Glucose, Injections, Intravenous, Insulin, Intestinal Absorption, Pancreas, Secretin

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