Unger, Roger H.

Lipotoxic heart disease in obese rats: Implications for human obesity

Zhou, Y.-T., Grayburn, P., Karim, A., Shimabukuro, M., Higa, M., Baetens, D., Orci, L., & Unger, R. H. (2000) · Proceedings of the National Academy of Sciences

Cardiovascular Function and Risk FactorsCardiovascular Disease and Adiposity

Cited by 1,265

Fatty acid-induced β cell apoptosis: A link between obesity and diabetes

Shimabukuro, M., Zhou, Y.-T., Levi, M., & Unger, R. H. (1998) · Proceedings of the National Academy of Sciences

Pancreatic function and diabetesSphingolipid Metabolism and Signaling

Cited by 1,142

Lipotoxicity in the Pathogenesis of Obesity-Dependent NIDDM: Genetic and Clinical Implications

Unger, R. H. (1995) · Diabetes

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 1,100

Lipotoxic diseases

Unger, R. H. (2002) · Annual Review of Medicine

Adipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and Obesity

Cited by 875

Studies of pancreatic alpha cell function in normal and diabetic subjects

Unger, R. H., Aguilar-Parada, E., Müller, W. A., & Eisentraut, A. M. (1970) · Journal of Clinical Investigation

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 837

Glucagonocentric restructuring of diabetes: A pathophysiologic and therapeutic makeover

Unger, R. H., & Cherrington, A. D. (2012) · Journal of Clinical Investigation

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 670

Abnormal Alpha-Cell Function in Diabetes: Response to Carbohydrate and Protein Ingestion

Müller, W. A., Faloona, G. R., Aguilar-Parada, E., & Unger, R. H. (1970) · New England Journal of Medicine

Pancreatic function and diabetesDiabetes Management and Research

Cited by 626

Cardiac Steatosis in Diabetes Mellitus: A 1 H-Magnetic Resonance Spectroscopy Study

McGavock, J. M., Lingvay, I., Zib, I., Tillery, T., Salas, N., Unger, R., Levine, B. D., Raskin, P., Victor, R. G., & Szczepaniak, L. S. (2007) · Circulation

Cardiovascular Function and Risk FactorsDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 612

Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity

Unger, R. H., & Scherer, P. E. (2010) · Trends in Endocrinology & Metabolism

Adipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and Obesity

Cited by 436

Regulation of fatty acid homeostasis in cells: Novel role of leptin

Unger, R. H., Zhou, Y.-T., & Orci, L. (1999) · Proceedings of the National Academy of Sciences

Regulation of Appetite and ObesityLipid metabolism and biosynthesis

Cited by 435

Comparison of a High-Carbohydrate Diet with a High-Monounsaturated-Fat Diet in Patients with Non-Insulin-Dependent Diabetes Mellitus

Garg, A., Bonanome, A., Grundy, S. M., Zhang, Z.-J., & Unger, R. H. (1988) · New England Journal of Medicine

Diabetes, Cardiovascular Risks, and LipoproteinsDiet and metabolism studies

Cited by 394

Entero-Insular Axis

Unger, R. H. (1969) · Archives of Internal Medicine

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 371

Glucagon physiology and pathophysiology in the light of new advances

Unger, R. H. (1985) · Diabetologia

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 361

Glucagon receptor knockout prevents insulin-deficient type 1 diabetes in mice

Lee, Y., Wang, M.-Y., Du, X. Q., Charron, M. J., & Unger, R. H. (2011) · Diabetes

Pancreatic function and diabetesDiabetes Management and Research

Cited by 327

Leptin therapy in insulin-deficient type I diabetes

Wang, M.-Y., Chen, L., Clark, G. O., Lee, Y., Stevens, R. D., Ilkayeva, O. R., Wenner, B. R., Bain, J. R., Charron, M. J., Newgard, C. B., et al. (2010) · Proceedings of the National Academy of Sciences

Diabetes Management and ResearchRegulation of Appetite and Obesity

Cited by 327

Insulin within islets is a physiologic glucagon release inhibitor

Maruyama, H., Hisatomi, A., Orci, L., Grodsky, G. M., & Unger, R. H. (1984) · Journal of Clinical Investigation

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 303

Diabetes and apoptosis: lipotoxicity

Kusminski, C. M., Shetty, S., Orci, L., Unger, R. H., & Scherer, P. E. (2009) · Apoptosis

Diabetes, Cardiovascular Risks, and LipoproteinsLipid metabolism and biosynthesis

Cited by 302

Diabetic Hyperglycemia: Link to Impaired Glucose Transport in Pancreatic β Cells

Unger, R. H. (1991) · Science

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 263

The effect of experimental insulin deficiency on glucagon secretion

Müller, W. A., Faloona, G. R., & Unger, R. H. (1971) · Journal of Clinical Investigation

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 240

Rapid transformation of white adipocytes into fat-oxidizing machines

Orci, L., Cook, W. S., Ravazzola, M., Wang, M.-Y., Park, B.-H., Montesano, R., & Unger, R. H. (2004) · Proceedings of the National Academy of Sciences

Adipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 234

The Banting Memorial Lecture 1975: Diabetes and the Alpha Cell

Unger, R. H. (1976) · Diabetes

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 234

Comparison of Effects of High and Low Carbohydrate Diets on Plasma Lipoproteins and Insulin Sensitivity in Patients With Mild NIDDM

Garg, A., Grundy, S. M., & Unger, R. H. (1992) · Diabetes

Diet and metabolism studiesDiet, Metabolism, and Disease

Cited by 228

Making insulin-deficient type 1 diabetic rodents thrive without insulin

Yu, X., Park, B.-H., Wang, M.-Y., Wang, Z. V., & Unger, R. H. (2008) · Proceedings of the National Academy of Sciences

Regulation of Appetite and ObesityPancreatic function and diabetes

Cited by 219

Feedback inhibition of insulin secretion by insulin: relation to the hyperinsulinemia of obesity

Elahi, D., Nagulesparan, M., Hershcopf, R. J., Muller, D. C., Tobin, J. D., Blix, P. M., Rubenstein, A. H., Unger, R. H., & Andres, R. (1982) · New England Journal of Medicine

Pancreatic function and diabetesDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 210