Propylthiouracil-Induced Hepatic Damage
Abstract
Two cases of propylthiouracil-induced liver damage have been observed. The first case is of an acute type of damage, proven by rechallenge; the second presents a clinical and histologic picture resembling chronic active hepatitis, with spontaneous remission.
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Except in cases of severe PTU-induced hepatotoxicity, MMI can be used to control thyrotoxicosis without ill effect.
“Except in cases of severe PTU-induced hepatotoxicity, MMI can be used to control the thyrotoxicosis without ill effect (160,161).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [160]
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- Authors
- Weiss, M.
- Corresponding author
- Weiss, Mordechai
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 1980-09-01
- Volume
- 140
- Issue
- 9
- Pages
- 1184
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W2069645466
- Cited by
- 62
- References
- 9
- Citations by year
- 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2016: 2 · 2015: 4 · 2014: 3
- FWCI
- 1.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Pharmacology › Drug-Induced Adverse Reactions
- Keywords
- propylthiouracil, drug-induced liver injury, hepatotoxicity, antithyroid drugs, acute liver injury, chronic active hepatitis, liver histopathology, spontaneous regression, drug rechallenge
- MeSH terms
- Adult, Female, Graves Disease, Humans, Hyperthyroidism, Liver, Liver Cirrhosis, Middle Aged, Propylthiouracil, Chemical and Drug Induced Liver Injury
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