Escherichia coli Bacteremia, Meningitis, and Hemochromatosis
Abstract
A 67-year-old man with Escherichia coli bacteremia and meningitis was found to have hemochromatosis. To my knowledge this is the first documented case of E coli meningitis occurring in the setting of hemochromatosis. The case raises issues regarding the role of chronic liver disease in the pathogenesis of gram-negative sepsis and the impact of iron loading on host immunocompetence and bacterial virulence.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Hereditary hemochromatosis patients are more susceptible to infections with Escherichia coli.
“Hereditary hemochromatosis patients, who are iron-overloaded as a result of hepcidin deficiency, are more susceptible to infections with Escherichia coli,3 Vibrio vulnificus,4 Listeria monocytogenes,5 and Yersinia enterocolitica.6,7”
From Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non-transferrin-bound iron (2017) · cites this paper as [3]
Cites
Listeria and gram-negative bacillary meningitis in New York City, 1972–1979
Cherubin, C. E., Marr, J. S., Sierra, M. F., & Becker, S. (1981) · The American Journal of Medicine · doi:10.1016/0002-9343(81)90106-6 · Cited by 225 · see citing works
The critical role of iron in host-bacterial interactions.
Payne, S. M., & Finkelstein, R. A. (1978) · Journal of Clinical Investigation · doi:10.1172/jci109062 · Cited by 183 · see citing works
Meningitis Caused by Gram-Negative Bacilli
Berk, S. L., & McCABE, W. R. (1980) · Annals of Internal Medicine · doi:10.7326/0003-4819-93-2-253 · Cited by 121 · see citing works
Listeria monocytogenes meningitis and decreased phagocytosis associated with iron overload.
van Asbeck, B. S., Verbrugh, H. A., van Oost, B. A., Marx, J. J. M., Imhof, H. W., & Verhoef, J. (1982) · BMJ · doi:10.1136/bmj.284.6315.542 · Cited by 104 · see citing works
Pathogenesis and immunology of experimental gonococcal infection: role of iron in virulence
Payne, S. M., & Finkelstein, R. A. (1975) · Infection and Immunity · doi:10.1128/iai.12.6.1313-1318.1975 · Cited by 78 · see citing works
Crane, L. R., & Lerner, A. M. (1978) · Medicine · doi:10.1097/00005792-197805000-00001 · Cited by 55 · see citing works
Effect of iron on leukocyte function: inactivation of H2O2 BY IRON
Kaplan, S. S., Quie, P. G., & Basford, R. E. (1975) · Infection and Immunity · doi:10.1128/iai.12.2.303-308.1975 · Cited by 29 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Sequestration and scavenging of iron in infection
Parrow, N. L., Fleming, R. E., & Minnick, M. F. (2013) · Infection and Immunity · doi:10.1128/iai.00602-13 · Cited by 261 · see citing works
Association of hemochromatosis with infectious diseases: expanding spectrum
Khan, F. A., Fisher, M. A., & Khakoo, R. A. (2007) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2007.04.007 · Cited by 216 · see citing works
Stefanova, D., Raychev, A., Arezes, J., Ruchala, P., Gabayan, V., Skurnik, M., Dillon, B. J., Horwitz, M. A., Ganz, T., Bulut, Y., et al. (2017) · Blood · doi:10.1182/blood-2017-03-772715 · Cited by 145 · see citing works
Leal, S. M., Roy, S., Vareechon, C., Carrion, S. D., Clark, H., Lopez-Berges, M. S., diPietro, A., Schrettl, M., Beckmann, N., Redl, B., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003436 · Cited by 111 · see citing works
Role of iron in the pathogenesis of respiratory disease
Ali, M. K., Kim, R., Karim, R., Mayall, J., Martin, K. L., Shahandeh, A., Abbasian, F., Starkey, M. R., Loustaud-Ratti, V., Johnstone, D. M., et al. (2017) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2017.05.003 · Cited by 112 · see citing works
Kell, D. B., & Pretorius, E. (2018) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12407 · Cited by 113 · see citing works
Ferritinophagy drives uropathogenic<i>Escherichia coli</i>persistence in bladder epithelial cells
Bauckman, K. A., & Mysorekar, I. U. (2016) · Autophagy · doi:10.1080/15548627.2016.1160176 · Cited by 100 · see citing works
Stefanova, D., Raychev, A., Deville, J., Humphries, R., Campeau, S., Ruchala, P., Nemeth, E., Ganz, T., & Bulut, Y. (2018) · Infection and Immunity · doi:10.1128/iai.00253-18 · Cited by 68 · see citing works
Bastos, P. A. D., Trindade, F., da Costa, J. P., Ferreira, R. M., & Vitorino, R. M. P. (2017) · Medicinal Research Reviews · doi:10.1002/med.21435 · Cited by 62 · see citing works
Hepcidin, iron, and bacterial infection
Barton, J. C., & Acton, R. T. (2019) · Vitamins and hormones · doi:10.1016/bs.vh.2019.01.011 · Cited by 53 · see citing works
Bichon, A., Aubry, C., Dubourg, G., Drouet, H., Lagier, J., Raoult, D., & Parola, P. (2017) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2017.12.003 · Cited by 37 · see citing works
Bauckman, K., Matsuda, R., Higgins, C. B., DeBosch, B. J., Wang, C., & Mysorekar, I. U. (2019) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00133.2018 · Cited by 31 · see citing works
Severe anaemia, iron deficiency, and susceptibility to invasive bacterial infections
Abuga, K. M., Nairz, M., MacLennan, C. A., & Atkinson, S. H. (2023) · Wellcome Open Research · doi:10.12688/wellcomeopenres.18829.1 · Cited by 29 · see citing works
How Severe Anaemia Might Influence the Risk of Invasive Bacterial Infections in African Children
Abuga, K. M., Muriuki, J. M., Williams, T. N., & Atkinson, S. H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186976 · Cited by 30 · see citing works
Hemochromatosis and Iron Overload: From Bench to Clinic
Barton, J. C. (2013) · The American Journal of the Medical Sciences · doi:10.1097/maj.0000000000000192 · Cited by 26 · see citing works
Leal, S. M., Roy, S., Vareechon, C., Carrion, S. D. J., Clark, H., López‐Berges, M. S., Pietro, A. D., Schrettl, M., Beckmann, N., Redl, B., et al. (2013) · PLoS Pathogens · doi:10.1371/annotation/4f388450-90fe-4c65-9b9b-71a2b7935ac0 · Cited by 26 · see citing works
Miller, H. K., Schwiesow, L., Au‐Yeung, W., & Auerbuch, V. (2016) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2016.00069 · Cited by 25 · see citing works
Spontaneous Escherichia coli Meningitis in an Adult
Mofredj, A. (2000) · Scandinavian Journal of Infectious Diseases · doi:10.1080/003655400459676 · Cited by 15 · see citing works
Spontaneous Escherichia coli Meningitis Associated with Hemophagocytic Lymphohistiocytosis
Chang, K., Lyu, R., & Tang, L. (2006) · Journal of the Formosan Medical Association · doi:10.1016/s0929-6646(09)60204-7 · Cited by 8 · see citing works
Akute Meningitis nach transrektaler Prostatapunktion
Meisel, F., Jacobi, C., Kollmar, R., Hug, A., Schwaninger, M., & Schwab, S. (2003) · Der Urologe · doi:10.1007/s00120-003-0468-3 · Cited by 8 · see citing works
Seydi, M., SOUMARÉ, M., Sow, A. I., Diop, B. M., & Sow, P. S. (2005) · Médecine et Maladies Infectieuses · doi:10.1016/j.medmal.2005.05.001 · Cited by 7 · see citing works
Barton, J. C., Edwards, C. Q., Phatak, P. D., Britton, R. S., & Bacon, B. R. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511777035.009 · Cited by 1 · see citing works
Gastrointestinal Mucormycosis and Presumptive Vibriosis in a Welder, a Case Report
Reddy, A. K., & Tuznik, N. M. (2023) · SN Comprehensive Clinical Medicine · doi:10.1007/s42399-023-01428-w · Cited by 1 · see citing works
Place du colibacille dans les septicemies a bacilles gram negatif
Beuscart, C., Leroy, O., Deloffre, H., Mouton, Y., & Groupe, S. E. S. (1987) · Médecine et Maladies Infectieuses · doi:10.1016/s0399-077x(87)80316-5 · Cited by 1 · see citing works
(2014) · ASM Press eBooks · doi:10.1128/9781555817541.ch4
- Authors
- Christopher, G. W.
- Corresponding author
- Christopher, George W.
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 1985-10-01
- Volume
- 145
- Issue
- 10
- Pages
- 1908
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W2024584476
- Cited by
- 26
- References
- 7
- Citations by year
- 2023: 2 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 2 · 2014: 1 · 2013: 4
- FWCI
- 0.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Keywords
- Escherichia coli, bacteremia, meningitis, hemochromatosis, gram-negative sepsis, chronic liver disease, iron overload, host immunocompetence, bacterial virulence
- MeSH terms
- Aged, Escherichia coli, Escherichia coli Infections, Hemochromatosis, Humans, Male, Meningitis, Virulence, Sepsis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
