Sequestration and scavenging of iron in infection

Parrow, Nermi L.; Fleming, Robert E.; Minnick, Michael F.

doi:10.1128/iai.00602-13

Cited by 261Iron Metabolism and DisordersBacterial Genetics and BiotechnologyEscherichia coli research studies

Sequestration and scavenging of iron in infection

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Parrow, Nermi L., Fleming, Robert E., Minnick, Michael F.·2013·Infection and Immunity

DOI 10.1128/iai.00602-13PMC PMC3811770

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Abstract

The proliferative capability of many invasive pathogens is limited by the bioavailability of iron. Pathogens have thus developed strategies to obtain iron from their host organisms. In turn, host defense strategies have evolved to sequester iron from invasive pathogens. This review explores the mechanisms employed by bacterial pathogens to gain access to host iron sources, the role of iron in bacterial virulence, and iron-related genes required for the establishment or maintenance of infection. Host defenses to limit iron availability for bacterial growth during the acute-phase response and the consequences of iron overload conditions on susceptibility to bacterial infection are also examined. The evidence summarized herein demonstrates the importance of iron bioavailability in influencing the risk of infection and the ability of the host to clear the pathogen.

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Host defense mechanisms act to sequester free iron away from invading pathogens.
“As such, host defense mechanisms act to sequester free iron away from invading pathogens [33].”
From Associations of genetically determined iron status across the phenome: A mendelian randomization study (2019) · cites this paper as [33]

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COVID-19 during Gestation: Maternal Implications of Evoked Oxidative Stress and Iron Metabolism Impairment
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The applications of 3D printing in wound healing: The external delivery of stem cells and antibiosis
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Advances in Ferritin Physiology and Possible Implications in Bacterial Infection
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Human Colon Mucosal Biofilms and Murine Host Communicate via Altered mRNA and microRNA Expression during Cancer
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Longitudinal Transcriptomic, Proteomic, and Metabolomic Analysis of Citrus limon Response to Graft Inoculation by Candidatus Liberibacter asiaticus
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The Serratia marcescens Siderophore Serratiochelin Is Necessary for Full Virulence during Bloodstream Infection
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Trauma-induced heme release increases susceptibility to bacterial infection
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Functional Characterization of FeoAB in Iron Acquisition and Pathogenicity in Riemerella anatipestifer
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Characterization of Foot and Mouth Disease Virus Serotype SAT-2 in Swamp Water Buffaloes (Bubalus bubalis) under the Egyptian Smallholder Production System
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Donor-dependent fecal microbiota transplantation efficacy against necrotizing enterocolitis in preterm pigs
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Authors: Parrow, N. L., Fleming, R. E., & Minnick, M. F.
Affiliations: National Institutes of Health (US)
Saint Louis University (US)
University of Montana (US)
ORCID: Parrow, Nermi L.
Fleming, Robert E.
Minnick, Michael F.
Venue: Infection and Immunity
Publisher: American Society for Microbiology
Published: 2013-10
Volume: 81
Issue: 10
Pages: 3503-3514
ISSN: 0019-9567 (ISSN-L)
1098-5522
DOI: 10.1128/iai.00602-13
PMC: PMC3811770
OpenAlex: W2126286427
Cited by: 261
References: 179
Citations by year: 2026: 14 · 2025: 26 · 2024: 25 · 2023: 24 · 2022: 25 · 2021: 26 · 2020: 31 · 2019: 26 · 2018: 16 · 2017: 16 · 2016: 11 · 2015: 11 · 2014: 8 · 2013: 1 · 2012: 1
FWCI: 7.42
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Infection and Immunity (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
The Mathematics Enthusiast (submittedVersion)
Funders: National Institutes of Health
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
Keywords: iron sequestration, iron scavenging, iron bioavailability, bacterial virulence, host-pathogen interaction, acute phase response, iron overload, bacterial iron acquisition, host defense against infection
MeSH terms: Animals, Bacteria, Homeostasis, Humans, Iron

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Sequestration and scavenging of iron in infection

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