Vibrio vulnificus septicemia in a patient with the hemochromatosis HFE C282Y mutation
Abstract
Vibrio vulnificus is an extremely invasive gram-negative bacillus found in marine waters that causes overwhelming bacteremia and shock that is associated with high mortality. Impaired iron metabolism has been implicated in the susceptibility to V vulnificus bacterial infections. We report a case of fatal V vulnificus sepsis in a 56-year-old man who died within 1 to 3 days after consuming raw seafood. At autopsy, he was found to have micronodular cirrhosis and iron overload. Postmortem genetic analysis revealed the presence of the hemochromatosis gene (HFE) C282Y mutation. To our knowledge, this is this first documented fatal case of V vulnificus infection in a patient proven to carry the HFE C282Y mutation. Because this patient was heterozygous for the major hereditary hemochromatosis mutation and was not previously diagnosed with clinical iron overload, the spectrum of clinical susceptibilities to V vulnificus infection may include carriers of the C282Y mutation.
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Hereditary hemochromatosis patients are more susceptible to infections with Vibrio vulnificus.
“Hereditary hemochromatosis patients, who are iron-overloaded as a result of hepcidin deficiency, are more susceptible to infections with Escherichia coli,3 Vibrio vulnificus,4 Listeria monocytogenes,5 and Yersinia enterocolitica.6,7”
From Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non-transferrin-bound iron (2017) · cites this paper as [4]
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CÁC YẾU TỐ ẢNH HƯỞNG TỚI NGUY CƠ TỬ VONG Ở BỆNH NHÂN NHIỄM KHUẨN HUYẾT DO VIBRIO VULNIFICUS
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- Authors
- Gerhard, G. S., Levin, K. A., Goldstein, J. P., Wojnar, M. M., Chorney, M. J., & Belchis, D. A.
- Affiliations
- Pennsylvania State University (US)
- Dartmouth College (US)
- Venue
- Archives of Pathology & Laboratory Medicine
- Published
- 2001-08
- Volume
- 125
- Issue
- 8
- Pages
- 1107-1109
- ISSN
- 0003-9985 (ISSN-L)
- 1543-2165
- OpenAlex
- W2130049858
- Cited by
- 58
- References
- 11
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 2 · 2016: 1 · 2015: 6 · 2014: 1 · 2013: 3 · 2012: 4
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Pathology & Laboratory Medicine (publishedVersion)
- PubMed (publishedVersion)
- Archives of Pathology & Laboratory Medicine
- Funders
- National Institutes of Health (1p01dk053430-01a1)
- National Institute on Aging (P01AG014731, AG14731)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 53430)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Vibrio bacteria research studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Infections and bacterial resistance
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Keywords
- Vibrio vulnificus, septicemia, hemochromatosis, HFE C282Y mutation, iron overload, sepsis susceptibility, raw seafood consumption, fatal infection, heterozygous carriers, micronodular cirrhosis
- MeSH terms
- Hemochromatosis Protein, Animals, Disseminated Intravascular Coagulation, Hemochromatosis, Heterozygote, HLA Antigens, Humans, Male, Membrane Proteins, Middle Aged, Multiple Organ Failure, Mutation, Ostreidae, Skin Diseases, Vibrio Infections, Histocompatibility Antigens Class I, Bacteremia, Seafood, Fatal Outcome
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