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Translating Weight Loss and Physical Activity Programs Into the Community to Preserve Mobility in Older, Obese Adults in Poor Cardiovascular Health
Open accessAbstract
BACKGROUND: Limitations in mobility are common among older adults with cardiovascular and cardiometabolic disorders and have profound effects on health and well-being. With the growing population of older adults in the United States, effective and scalable public health approaches are needed to address this problem. Our goal was to determine the effects of a physical activity and weight loss intervention on 18-month change in mobility among overweight or obese older adults in poor cardiovascular health. METHODS: The study design was a translational, randomized controlled trial of physical activity (PA) and weight loss (WL) on mobility in overweight or obese older adults with cardiovascular disease (CVD) or at risk for CVD. The study was conducted within the community infrastructure of Cooperative Extension Centers. Participants were randomized to 1 of 3 interventions: PA, WL + PA, or a successful aging (SA) education control arm. The primary outcome was time to complete a 400-m walk in seconds (400MWT). RESULTS: A significant treatment effect (P = .002) and follow-up testing revealed that the WL + PA group improved their 400MWT (adjusted mean [SE], 323.3 [3.7] seconds) compared with both PA (336.3 [3.9] seconds; P = .02) and SA (341.3 [3.9] seconds; P < .001). Participants with poorer mobility at baseline benefited the most (P < .001). CONCLUSION: Existing community infrastructures can be effective in delivering lifestyle interventions to enhance mobility in older adults in poor cardiovascular health with deficits in mobility; attention should be given to intervening on both weight and sedentary behavior since weight loss is critical to long-term improvement in mobility. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00119795.
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“Likewise, many studies from our group (31, 32, 33), and others (34, 35), show improvements in muscle strength and function in older adults participating in lifestyle-based weight loss interventions, despite experiencing significant weight and LM loss (36, 37).”
From G LP1Ra ‐based therapies and DXA ‐acquired musculoskeletal health outcomes: a focused meta‐analysis of placebo‐controlled trials (2025) · cites this paper as [31]
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Metadata
- Authors
- Rejeski, W. J., Brubaker, P. H., Goff, D. C., Bearon, L. B., McClelland, J. W., Perri, M. G., & Ambrosius, W. T.
- Affiliations
- Wake Forest University (US)
- North Carolina State University (US)
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 2011-05-23
- Volume
- 171
- Issue
- 10
- Pages
- 880-6
- ISSN
- 0003-9926 (ISSN-L)
- PMC
- PMC4425192
- OpenAlex
- W1964458672
- Cited by
- 156
- References
- 33
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 4 · 2023: 4 · 2022: 9 · 2021: 7 · 2020: 13 · 2019: 11 · 2018: 9 · 2017: 12 · 2016: 10 · 2015: 16 · 2014: 14 · 2013: 21 · 2012: 13
- FWCI
- 11.12
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Archives of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (P30AG028740, P30AG021332)
- National Heart, Lung, and Blood Institute (HL076441-01A1, R18HL076441, R01HL076441)
- National Center for Research Resources (M01RR007122)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Keywords
- mobility (physical function), older adults, obesity, weight loss, physical activity, cardiovascular disease, cardiometabolic disease, successful aging, community-based intervention, lifestyle intervention, sedentary behavior
- MeSH terms
- Aged, Cardiovascular Diseases, Female, Follow-Up Studies, Humans, Male, Middle Aged, Motor Activity, Obesity, Prospective Studies, Public Health, Severity of Illness Index, Weight Loss, Exercise, Geriatric Assessment, Walking, Treatment Outcome, Age Distribution, Sex Distribution, Risk Assessment, Patient Selection, Mobility Limitation
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