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Cited by 340

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

Physiology of Status Epilepticus in Primates

Meldrum, B. S., Horton, R. W.·1973·Archives of Neurology

Abstract

In adolescent baboons the intravenous injection of bicuculline induced generalized seizures lasting up to five hours, which sometimes led to brain damage or death. Marked initial rises in arterial and cerebral venous pressure were accompanied by severe metabolic and respiratory acidosis, hyperglycemia, and reduced cerebral arteriovenous (AV) differences for oxygen (O2) and carbon dioxide (CO2). In the second phase of the seizure (+25 to +300 minutes) blood pressure was normal or low, cerebral AV differences for O2 andCO wereenhanced, but cerebral venous oxygen tension was not critically reduced. There was severe hyperpyrexia, and hyperkalemia, and sometimes hypoglycemia. Death was cardiovascular in origin. A behavioral and electroencephalographic recovery could occur within three hours of generalized seizure activity lasting one to two hours.

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Crossref · 10.1001/archneur.1973.00490190019001

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Metadata

Authors
Meldrum, B. S., & Horton, R. W.
Venue
Archives of Neurology
Published
1973-01-01
Volume
28
Issue
1
Pages
1-9
ISSN
0003-9942 (ISSN-L)
OpenAlex
W2049175903
Cited by
340
References
12
FWCI
7.17
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Physiology of Status Epilepticus in Primates. https://app.cochat.ai/papers/10.1001/archneur.1973.00490190019001
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Meldrum, B. S., & Horton, R. W. (1973). Physiology of Status Epilepticus in Primates. Archives of Neurology. https://doi.org/10.1001/archneur.1973.00490190019001

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.